Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Alexey G. Kruglov"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16955 (2023)
Temperature is a crucial regulator of the rate and direction of biochemical reactions and cell processes. The recent data indicating the presence of local thermal gradients associated with the sites of high-rate thermogenesis, on the one hand, demons
Externí odkaz:
https://doaj.org/article/6b51e21915de486bb92a1b5f53715a89
Autor:
Anna B. Nikiforova, Yulia L. Baburina, Marina P. Borisova, Alexey K. Surin, Ekaterina S. Kharechkina, Olga V. Krestinina, Maria Y. Suvorina, Svetlana A. Kruglova, Alexey G. Kruglov
Publikováno v:
Cells, Vol 12, Iss 19, p 2414 (2023)
Monomers, dimers, and individual FOF1-ATP synthase subunits are, presumably, involved in the formation of the mitochondrial permeability transition pore (PTP), whose molecular structure, however, is still unknown. We hypothesized that, during the Ca2
Externí odkaz:
https://doaj.org/article/b10112129a364bc88ccecf20b21095e6
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9237 (2023)
The opening of the permeability transition pore (PTP) in mitochondria is a key event in the initiation of cell death in various pathologic states, including ischemia/reperfusion. The activation of K+ transport into mitochondria protects cells from is
Externí odkaz:
https://doaj.org/article/5aa1c51e16b34038a9ae79481a6b177f
Autor:
Ekaterina S. Kharechkina, Anna B. Nikiforova, Konstantin N. Belosludtsev, Tatyana I. Rokitskaya, Yuri N. Antonenko, Alexey G. Kruglov
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1045 (2021)
Pioglitazone (PIO) is an insulin-sensitizing antidiabetic drug, which normalizes glucose and lipid metabolism but may provoke heart and liver failure and chronic kidney diseases. Both therapeutic and adverse effects of PIO can be accomplished through
Externí odkaz:
https://doaj.org/article/132070f6221b47b3a2a2edfb90a56b86
Autor:
Anna B. Nikiforova, Yulia L. Baburina, Marina P. Borisova, Alexey K. Surin, Ekaterina S. Kharechkina, Olga V. Krestinina, Maria Y. Suvorina, Svetlana A. Kruglova, Alexey G. Kruglov
Monomers, dimers, and individual FOF1-ATP synthase subunits are, presumably, involved in the formation of the mitochondrial permeability transition pore (PTP), which molecular structure, however, is still unknown. We hypothesized that upon the Ca2+-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb3c9d991b8a99e2cdc03b176c22fad
https://doi.org/10.1101/2022.09.28.508998
https://doi.org/10.1101/2022.09.28.508998
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8560, p 8560 (2021)
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8560, p 8560 (2021)
The opening of the permeability transition pore (mPTP) in mitochondria initiates cell death in numerous diseases. The regulation of mPTP by NAD(H) in the mitochondrial matrix is well established
however, the role of extramitochondrial (cytosolic
however, the role of extramitochondrial (cytosolic
Autor:
Alexey G. Kruglov, Svetlana A. Kruglova, Anna B. Nikiforova, Irina Odinokova, Ekaterina S. Kharechkina
Publikováno v:
The FASEB Journal. 35
The size of the permeability transition pore (PTP) is accepted to be ≤1.5 kDa. However, different authors reported values from 650 to 4000 Da. The present study is focused on the variability of the average PTP size in and between mitochondrial samp
Autor:
Svetlana A. Kruglova, Vera V. Teplova, Irina Odinokova, Olga Krestinina, Ekaterina S. Kharechkina, Yulia Baburina, Anna B. Nikiforova, Alexey G. Kruglov
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1863:771-783
Background The opening of the permeability transition pore (PTP) in mitochondria plays a critical role in the pathogenesis of numerous diseases. Mitochondrial matrix pyridine nucleotides are potent regulators of the PTP, but the role of extramitochon
Autor:
A. I. Zvyagina, Olga Krestinina, Alexey G. Kruglov, Yulia Baburina, Irina Odinokova, Linda Sotnikova, Irina Fadeeva, Roman Krestinin
Publikováno v:
Biomedicines
Biomedicines, Vol 8, Iss 437, p 437 (2020)
Volume 8
Issue 10
Biomedicines, Vol 8, Iss 437, p 437 (2020)
Volume 8
Issue 10
Mitochondria are key organelles of the cell because their main function is the capture of energy-rich substrates from the cytoplasm and oxidative cleavage with the generation of carbon dioxide and water, processes that are coupled with the synthesis
Autor:
Marina Solovieva, Elena Shishkova, M. I. Kobyakova, Olga Krestinina, R. S. Fadeev, Yulia Baburina, And Vladimir Akatov, Yuri V. Shatalin, Alexey G. Kruglov, Vadim Rogachevsky, Ekaterina S. Kharechkina
Publikováno v:
Biomolecules
Volume 10
Issue 1
Biomolecules, Vol 10, Iss 1, p 69 (2020)
Volume 10
Issue 1
Biomolecules, Vol 10, Iss 1, p 69 (2020)
We have shown that hydroxycobalamin (vitamin B12b) increases the toxicity of diethyldithiocarbamate (DDC) to tumor cells by catalyzing the formation of disulfiram (DSF) oxi-derivatives. The purpose of this study was to elucidate the mechanism of tumo