Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Alexey G Ryazanov"'
Autor:
Vladimir Chubanov, Silvia Ferioli, Annika Wisnowsky, David G Simmons, Christin Leitzinger, Claudia Einer, Wenke Jonas, Yuriy Shymkiv, Harald Bartsch, Attila Braun, Banu Akdogan, Lorenz Mittermeier, Ludmila Sytik, Friedrich Torben, Vindi Jurinovic, Emiel PC van der Vorst, Christian Weber, Önder A Yildirim, Karl Sotlar, Annette Schürmann, Susanna Zierler, Hans Zischka, Alexey G Ryazanov, Thomas Gudermann
Publikováno v:
eLife, Vol 5 (2016)
Mg2+ regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg2+. Capitalizing on a set of newly generated mouse models, we provide an integrated mechanistic
Externí odkaz:
https://doaj.org/article/b987aed5a28e4033adf9dc2ee15b0310
Autor:
Robert H Newman, Jianfei Hu, Hee‐Sool Rho, Zhi Xie, Crystal Woodard, John Neiswinger, Christopher Cooper, Matthew Shirley, Hillary M Clark, Shaohui Hu, Woochang Hwang, Jun Seop Jeong, George Wu, Jimmy Lin, Xinxin Gao, Qiang Ni, Renu Goel, Shuli Xia, Hongkai Ji, Kevin N Dalby, Morris J Birnbaum, Philip A Cole, Stefan Knapp, Alexey G Ryazanov, Donald J Zack, Seth Blackshaw, Tony Pawson, Anne‐Claude Gingras, Stephen Desiderio, Akhilesh Pandey, Benjamin E Turk, Jin Zhang, Heng Zhu, Jiang Qian
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-12 (2013)
Abstract The landscape of human phosphorylation networks has not been systematically explored, representing vast, unchartered territories within cellular signaling networks. Although a large number of in vivo phosphorylated residues have been identif
Externí odkaz:
https://doaj.org/article/6886196250374d4893d1b1be6feccd1e
Autor:
Francisco J. Rios, Zhi-Guo Zou, Adam P. Harvey, Katie Y. Harvey, Livia L. Camargo, Karla B. Neves, Sarah E. F. Nichol, Rheure Alves-Lopes, Alexius Cheah, Maram Zahraa, Alexey G. Ryazanov, Lillia Ryazanova, Thomas Gudermann, Vladimir Chubanov, Augusto C. Montezano, Rhian M. Touyz
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Deficiency of the Mg2+-permeable channel/α-kinase TRPM7 in mice increases susceptibility to cardiovascular and renal fibrosis induced by aldosterone and salt.
Externí odkaz:
https://doaj.org/article/cb2321b1b4554eefad7adf3bec82bdc7
Autor:
Jared L. Johnson, Tomer M. Yaron, Emily M. Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M. Cizin, Benjamin M. Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, Norbert F. Käufer, Maxim V. Dorovkov, Alexey G. Ryazanov, Yuichiro Takagi, Edward R. Kastenhuber, Marcus D. Goncalves, Benjamin D. Hopkins, Olivier Elemento, Dylan J. Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V. Hornbeck, Benjamin E. Turk, Michael B. Yaffe, Lewis C. Cantley
Publikováno v:
Nature. 613:759-766
Protein phosphorylation is one of the most widespread post-translational modifications in biology1,2. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24067cbcb16c95a6f48186aaec1c115c
https://doi.org/10.1038/s41586-022-05575-3
https://doi.org/10.1038/s41586-022-05575-3
Publikováno v:
Biochemistry (Moscow). 87:628-639
Abstract In this study, we conducted a comparative analysis of the structure of agonists and antagonists of transmembrane (TM) β-adrenoceptors (β-ARs) and their interactions with the β-ARs and proposed the mechanism of receptor activation. A chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22144e22b6433db23875fbeaf3017fbb
https://doi.org/10.1134/s0006297922070057
https://doi.org/10.1134/s0006297922070057
Autor:
Nicole P. Kasica, Xueyan Zhou, Hannah M. Jester, Caroline E. Holland, Alexey G. Ryazanov, Tom E. Forshaw, Cristina M. Furdui, Tao Ma
Publikováno v:
Frontiers in aging neuroscience. 14
Maintenance of memory and synaptic plasticity depends on de novo protein synthesis, and accumulating evidence implicates a role of dysregulated mRNA translation in cognitive impairments associated with Alzheimer’s disease (AD). Accumulating evidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f264112e158f7009b9b23d6d4783d42
https://pubmed.ncbi.nlm.nih.gov/36158543
https://pubmed.ncbi.nlm.nih.gov/36158543
Autor:
Jared L. Johnson, Tomer M. Yaron, Emily M. Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M. Cizin, Benjamin M. Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, Norbert Käufer, Maxim V. Dorovkov, Alexey G. Ryazanov, Yuichiro Takagi, Edward R. Kastenhuber, Marcus D. Goncalves, Olivier Elemento, Dylan J. Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Rune Linding, John Blenis, Peter V. Hornbeck, Benjamin E. Turk, Michael B. Yaffe, Lewis C. Cantley
Protein phosphorylation is one of the most widespread post-translational modifications in biology. With the advent of mass spectrometry-based phosphoproteomics, more than 200,000 sites of serine and threonine phosphorylation have been reported, of wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fba75afb0655e8d4e5e9b6234f8a04b6
https://doi.org/10.1101/2022.05.22.492882
https://doi.org/10.1101/2022.05.22.492882
Autor:
Wenzhong P Yang, Hanzhi Wu, Xueyan Zhou, Caroline E Holland, Tao Ma, Nicole P. Kasica, Xin Wang, Elizabeth Koscielniak, Jingyun Lee, Alexey G. Ryazanov, Anderson Cox, Cristina M. Furdui, Helena R. Zimmermann
It is imperative to develop novel therapeutic strategies for Alzheimer’s disease (AD) and related dementia syndromes based on solid mechanistic studies. Maintenance of memory and synaptic plasticity relies on de novo protein synthesis, which is par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa52d7a4beb13907b5930b0e479e7087
https://doi.org/10.1101/2021.07.15.452522
https://doi.org/10.1101/2021.07.15.452522
Autor:
Xueyan Zhou, Tao Ma, Nicole P. Kasica, Brenna C. Beckelman, Wenzhong Yang, Alexey G. Ryazanov, C. Dirk Keene, Helena R. Zimmermann
Publikováno v:
Journal of Clinical Investigation. 129:820-833
Molecular signaling mechanisms underlying Alzheimer’s disease (AD) remain unclear. Maintenance of memory and synaptic plasticity depend on de novo protein synthesis, dysregulation of which is implicated in AD. Recent studies showed AD-associated hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0146ce2148e086fc507f5cecc633c74b
https://doi.org/10.1172/jci122954
https://doi.org/10.1172/jci122954
Publikováno v:
Neurobiol Aging
Impaired mRNA translation (protein synthesis) is linked to Alzheimer's disease (AD) pathophysiology. Recent studies revealed the role of increased phosphorylation of eukaryotic elongation factor 2 (eEF2) in AD-associated cognitive deficits. Phosphory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcf325759c1116f9a5586d251c945d9
https://pubmed.ncbi.nlm.nih.gov/33341653
https://pubmed.ncbi.nlm.nih.gov/33341653