Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alexey E Granovsky"'
Autor:
Anne N Shemon, Gary L Heil, Alexey E Granovsky, Mathew M Clark, Dan McElheny, Alexander Chimon, Marsha R Rosner, Shohei Koide
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10479 (2010)
BackgroundRaf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively regulate growth factor signaling by the Raf/MAP kinase pathway. RKIP has also been sho
Externí odkaz:
https://doaj.org/article/599a1f1f544e4bb28a7ae4ba60f27bbd
Publikováno v:
Biochemistry. 42:3305-3310
Photoreceptor cGMP phosphodiesterase (PDE6) is the effector enzyme in the vertebrate visual transduction cascade. The activity of rod PDE6 catalytic alpha- and beta-subunits is blocked in the dark by two inhibitory Pgamma-subunits. The inhibition is
Publikováno v:
Biochemistry. 40:13209-13215
In response to light, a photoreceptor G protein, transducin, activates cGMP-phosphodiesterase (PDE6) by displacing the inhibitory gamma-subunits (Pgamma) from the enzyme's catalytic sites. Evidence suggests that the activation of PDE6 involves a conf
Publikováno v:
Journal of Biological Chemistry. 276:21698-21703
Photoreceptor cGMP phosphodiesterases (PDE6) are uniquely qualified to serve as effector enzymes in the vertebrate visual transduction cascade. In the dark-adapted photoreceptors, the activity of PDE6 is blocked via tight association with the inhibit
Publikováno v:
Journal of Biological Chemistry. 274:7865-7869
The visual GTP-binding protein, transducin, couples light-activated rhodopsin (R*) with the effector enzyme, cGMP phosphodiesterase in vertebrate photoreceptor cells. The region corresponding to the alpha4-helix and alpha4-beta6 loop of the transduci
Autor:
Alexey E. Granovsky, Tamara L. Haik, Nikolai O. Artemyev, Jackie D. Corbin, Randall L. McEntaffer, Sharron H. Francis, Michael Natochin
Publikováno v:
Journal of Biological Chemistry. 273:24485-24490
Chimeric cGMP phosphodiesterases (PDEs) have been constructed using components of the cGMP-binding PDE (PDE5) and cone photoreceptor phosphodiesterase (PDE6alpha') in order to study structure and function of the photoreceptor enzyme. A fully function
Publikováno v:
Cell Biochemistry and Biophysics. 28:115-133
In the dark, the activity of the rod cGMP phosphodiesterase (PDE) catalytic alpha- and beta-subunits (P alpha beta) is inhibited by two gamma-subunits (P gamma). On light stimulation of the photoreceptor cells, the GTP-bound alpha-subunit of visual G
Publikováno v:
Journal of Biological Chemistry. 272:17444-17449
The intrinsic GTPase activity of transducin controls inactivation of the effector enzyme, cGMP phosphodiesterase (PDE), during turnoff of the visual signal. The inhibitory gamma-subunit of PDE (Pgamma), an unidentified membrane factor and a retinal s
Autor:
Shohei Koide, Alexander Chimon, Anne N. Shemon, Alexey E. Granovsky, Gary Heil, Mathew M. Clark, Marsha Rich Rosner, Dan McElheny
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10479 (2010)
PLoS ONE
PLoS ONE
BackgroundRaf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively regulate growth factor signaling by the Raf/MAP kinase pathway. RKIP has also been sho
Autor:
Anne N. Shemon, Akira Imamoto, Eva M. Eves, Shohei Koide, Mathew C Clark, Lingchun Zeng, Alexey E. Granovsky, Gary Heil, Marsha Rich Rosner
Publikováno v:
The FASEB Journal. 23