Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alexey Brazhe"'
Autor:
Alexander Popov, Nadezda Brazhe, Kseniia Morozova, Konstantin Yashin, Maxim Bychkov, Olga Nosova, Oksana Sutyagina, Alexey Brazhe, Evgenia Parshina, Li Li, Igor Medyanik, Dmitry E. Korzhevskii, Zakhar Shenkarev, Ekaterina Lyukmanova, Alexei Verkhratsky, Alexey Semyanov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract How aging affects cells of the human brain active milieu remains largely unknown. Here, we analyze astrocytes and neurons in the neocortical tissue of younger (22–50 years) and older (51–72 years) adults. Aging decreases the amount of re
Externí odkaz:
https://doaj.org/article/ceeb2da29c3a47b68b9403c949de291d
Autor:
Isabel N. Christie, Shefeeq M. Theparambil, Alice Braga, Maxim Doronin, Patrick S. Hosford, Alexey Brazhe, Alexander Mascarenhas, Shereen Nizari, Anna Hadjihambi, Jack A. Wells, Adrian Hobbs, Alexey Semyanov, Andrey Y. Abramov, Plamena R. Angelova, Alexander V. Gourine
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113514- (2023)
Summary: During hypoxia, increases in cerebral blood flow maintain brain oxygen delivery. Here, we describe a mechanism of brain oxygen sensing that mediates the dilation of intraparenchymal cerebral blood vessels in response to reductions in oxygen
Externí odkaz:
https://doaj.org/article/e103ac5e3e2a45a0b6df0577e2df1764
Publikováno v:
Mathematics, Vol 11, Iss 3, p 628 (2023)
The mathematical modeling of synaptically connected neuronal networks is an established instrument for gaining insights into dynamics of neuronal ensembles and information processing in the nervous system. Recently, calcium signaling in astrocytes—
Externí odkaz:
https://doaj.org/article/8e1375d589fd401081aa6d15a0b18835
Autor:
Nephtali Marina, Isabel N. Christie, Alla Korsak, Maxim Doronin, Alexey Brazhe, Patrick S. Hosford, Jack A. Wells, Shahriar Sheikhbahaei, Ibrahim Humoud, Julian F. R. Paton, Mark F. Lythgoe, Alexey Semyanov, Sergey Kasparov, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The brain receives 20% of cardiac output, but in accord with the current knowledge lacks a specialized sensor of its own blood flow. Here, the authors show that brain astrocytes detect drops in perfusion and trigger compensatory increases in arterial
Externí odkaz:
https://doaj.org/article/460633936e6841f2ab72308399796298
Autor:
Reena P. Murmu, Jonas C. Fordsmann, Changsi Cai, Alexey Brazhe, Kirsten J. Thomsen, Martin Lauritzen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Middle cerebral artery occlusion (MCAO) induces ischemia characterized by a densely ischemic focus, and a less densely ischemic penumbral zone in which neurons and astrocytes display age-dependent dynamic variations in spontaneous Ca2+ activities. Ho
Externí odkaz:
https://doaj.org/article/18cd3004d31f436b9a240176edf88754
Autor:
Nikolay Gavrilov, Inna Golyagina, Alexey Brazhe, Annalisa Scimemi, Vadim Turlapov, Alexey Semyanov
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Distal astrocytic processes have a complex morphology, reminiscent of branchlets and leaflets. Astrocytic branchlets are rod-like processes containing mitochondria and endoplasmic reticulum, capable of generating inositol-3-phosphate (IP3)-dependent
Externí odkaz:
https://doaj.org/article/cababff546284cb5bd101a559a33427a
Autor:
Alex Plata, Albina Lebedeva, Pavel Denisov, Olga Nosova, Tatiana Y. Postnikova, Alexey Pimashkin, Alexey Brazhe, Aleksey V. Zaitsev, Dmitri A. Rusakov, Alexey Semyanov
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Epilepsy is a group of neurological disorders commonly associated with the neuronal malfunction leading to generation of seizures. Recent reports point to a possible contribution of astrocytes into this pathology. We used the lithium-pilocarpine mode
Externí odkaz:
https://doaj.org/article/5150cf41606f4a728351b8253fc9a128
Autor:
Anna Fedotova, Alexey Brazhe, Maxim Doronin, Dmitro Toptunov, Evgeny Pryazhnikov, Leonard Khiroug, Alexei Verkhratsky, Alexey Semyanov
Publikováno v:
Function.
Orchestrated activity of different cell types and their interactions within the brain active milieu provide the cellular basis for brain functions. Locomotion triggers a coordinated response of both neurons and astrocytes in various brain regions. He
Autor:
Alexander Popov, Nadezda Brazhe, Kseniia Morozova, Konstantin Yashin, Maxim Bychkov, Olga Nosova, Oksana Sutyagina, Alexey Brazhe, Evgenia Parshina, Li Li, Igor Medyanik, Dmitry E Korzhevskii, Zakhar Shenkarev, Ekaterina Lyukmanova, Alexei Verkhratsky, Alexey Semyanov
How aging affects cellular components of the human brain active milieu remains largely unknown. We analyzed astrocytes and neurons in the neocortical access tissue of younger (22 - 50 years) and older (51 - 72 years) adult patients who underwent glio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7419f73c32989a56aed8b3acbe92b9d4
https://doi.org/10.1101/2022.10.31.514523
https://doi.org/10.1101/2022.10.31.514523
Autor:
Alexander Popov, Nadezda Brazhe, Anna Fedotova, Alisa Tiaglik, Maxim Bychkov, Kseniia Morozova, Alexey Brazhe, Dmitry Aronov, Ekaterina Lyukmanova, Natalia Lazareva, Li Li, Evgeni Ponimaskin, Alexei Verkhratsky, Alexey Semyanov
Publikováno v:
Popov, A, Brazhe, N, Fedotova, A, Tiaglik, A, Bychkov, M, Morozova, K, Brazhe, A, Aronov, D, Lyukmanova, E, Lazareva, N, Li, L, Ponimaskin, E, Verkhratsky, A & Semyanov, A 2022, ' A high-fat diet changes astrocytic metabolism to promote synaptic plasticity and behavior ', Acta Physiologica . https://doi.org/10.1111/apha.13847
AimA high-fat diet (HFD) is generally considered to negatively influence the body, the brain, and cognition. Nonetheless, fat and fatty acids are essential for nourishing and constructing brain tissue. Astrocytes are central for lipolysis and fatty a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15499b3ab0a6caee38329919f9c49796
https://pure.manchester.ac.uk/ws/files/221048247/AAM_Acta_Physiol.pdf
https://pure.manchester.ac.uk/ws/files/221048247/AAM_Acta_Physiol.pdf