Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Alexey Amunts"'
Autor:
Vivek Singh, Yuzuru Itoh, Samuel Del’Olio, Asem Hassan, Andreas Naschberger, Rasmus Kock Flygaard, Yuko Nobe, Keiichi Izumikawa, Shintaro Aibara, Juni Andréll, Paul C. Whitford, Antoni Barrientos, Masato Taoka, Alexey Amunts
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated mitoribosomal RNA (rRNA) modifi
Externí odkaz:
https://doaj.org/article/25b459b1c9f4493c81a55c314635cfbf
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Structural and evolutionary analysis of a diverged mitoribosome with rRNA that is split in 13 pieces reveals a non-canonical reduced form of the 5 S, permutation of domain I, and how the fragmentation pattern links to the concept of a primordial ribo
Externí odkaz:
https://doaj.org/article/0cde3ab678cd4dc6a9a02fd542b79e79
Autor:
Ondřej Gahura, Alexander Mühleip, Carolina Hierro-Yap, Brian Panicucci, Minal Jain, David Hollaus, Martina Slapničková, Alena Zíková, Alexey Amunts
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Mitochondrial ATP synthase assemble into oligomers. Here, authors resolve the structure of trypanosomal ATP synthase, showing that its dimerization is essential for function and evolutionary conserved.
Externí odkaz:
https://doaj.org/article/033e79272bfa4cdc9ca0a33a7abdda7a
Autor:
Yuzuru Itoh, Vivek Singh, Anas Khawaja, Andreas Naschberger, Minh Duc Nguyen, Joanna Rorbach, Alexey Amunts
Publikováno v:
eLife, Vol 11 (2022)
The mitoribosome regulates cellular energy production, and its dysfunction is associated with aging. Inhibition of the mitoribosome can be caused by off-target binding of antimicrobial drugs and was shown to be coupled with a bilateral decreased visu
Externí odkaz:
https://doaj.org/article/71e26c92444548e79d73d278270bfc82
Autor:
Patrick Cottilli, Yuzuru Itoh, Yuko Nobe, Anton S. Petrov, Purificación Lisón, Masato Taoka, Alexey Amunts
Publikováno v:
Plant Communications, Vol 3, Iss 5, Pp 100342- (2022)
Protein synthesis in crop plants contributes to the balance of food and fuel on our planet, which influences human metabolic activity and lifespan. Protein synthesis can be regulated with respect to changing environmental cues via the deposition of c
Externí odkaz:
https://doaj.org/article/3edf429bdf4a4e71af9ca6e9bcefbd4e
Autor:
Alexander Mühleip, Rasmus Kock Flygaard, Jana Ovciarikova, Alice Lacombe, Paula Fernandes, Lilach Sheiner, Alexey Amunts
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Structural and functional analysis of mitochondria from the human parasite Toxoplasma gondii reveals that its ATP synthase assembles into cyclic hexamers, arranged together in a form of pentagonal pyramids required for maintenance of cristae morpholo
Externí odkaz:
https://doaj.org/article/56947c119cc747a6b15d66b6a2139440
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Structural analyses of the translating mitoribosome from Neurospora crassa reveal insights into the interactions with mRNA and tRNA, assembly of the large subunit, and evolution of the tunnel for nascent polypeptide.
Externí odkaz:
https://doaj.org/article/e256947c606d41568f70372041d9abc0
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Mitochondrial ATP synthases are involved in shaping the mitochondrial cristae. The cryo-EM structure of type III ATP synthase reveals the architecture of the unusual, asymmetrical, U-shaped dimer and offers insights into the interaction with the natu
Externí odkaz:
https://doaj.org/article/7d4c0874d55a42c7ab5f4fe8e73119c5
Autor:
Anas Khawaja, Yuzuru Itoh, Cristina Remes, Henrik Spåhr, Olessya Yukhnovets, Henning Höfig, Alexey Amunts, Joanna Rorbach
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Translation within mitochondria relies upon specialized mitoribosomes and initiation factors. Here the authors use Cryo-EM and single molecule approaches to describe the early steps leading to translation initiation in human mitochondria, and the rol
Externí odkaz:
https://doaj.org/article/c511e0e642764f37845e6699bdca4970
Autor:
Neha Nirwan, Yuzuru Itoh, Pratima Singh, Sutirtha Bandyopadhyay, Kutti R. Vinothkumar, Alexey Amunts, Kayarat Saikrishnan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
McrBC is a bacterial antiphage defense system that cleaves methylated DNA and is composed of the AAA+ GTPase motor McrB and the endonuclease McrC. Here, the authors present the cryo-EM structure of E. coli McrBC that reveals how McrC inserts a stalk-
Externí odkaz:
https://doaj.org/article/5c68680d22bd42158914fb12b267b2bd