Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Alexey A. Lagunin"'
Autor:
Anastasia V. Rudik, Alexander V. Dmitriev, Alexey A. Lagunin, Dmitry A. Filimonov, Vladimir V. Poroikov
Publikováno v:
ACS Omega, Vol 8, Iss 48, Pp 45774-45778 (2023)
Externí odkaz:
https://doaj.org/article/20f971efae70422da3963e87536132a7
Autor:
Dmitry A. Dmitriev, Boris V. Shilov, Michail M. Polunin, Anton D. Zadorozhny, Alexey A. Lagunin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17240 (2023)
Auditory neuropathy spectrum disorder (ANSD) associated with mutations of the OTOF gene is one of the common types of sensorineural hearing loss of a hereditary nature. Due to its high genetic heterogeneity, ANSD is considered one of the most difficu
Externí odkaz:
https://doaj.org/article/fb0d7b7edd2f4323b525b45b65f7613e
Autor:
Anastasiia Iu. Paremskaia, Anastassia V. Rudik, Dmitry A. Filimonov, Alexey A. Lagunin, Vladimir V. Poroikov, Olga A. Tarasova
Publikováno v:
Viruses, Vol 15, Iss 11, p 2245 (2023)
Predicting viral drug resistance is a significant medical concern. The importance of this problem stimulates the continuous development of experimental and new computational approaches. The use of computational approaches allows researchers to increa
Externí odkaz:
https://doaj.org/article/9b1ff66c141b42b7bbbf74f3888e5d9a
Publikováno v:
Life, Vol 13, Iss 9, p 1807 (2023)
Drug resistance to anticancer drugs is a serious complication in patients with cancer. Typically, drug resistance occurs due to amino acid substitutions (AAS) in drug target proteins. The study aimed at developing and validating a new approach to the
Externí odkaz:
https://doaj.org/article/7928706d4fe0491fb310e9323029a73d
Autor:
Yuriy M. Kositsyn, Murilo S. de Abreu, Tatiana O. Kolesnikova, Alexey A. Lagunin, Vladimir V. Poroikov, Hasmik S. Harutyunyan, Konstantin B. Yenkoyan, Allan V. Kalueff
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9482 (2023)
Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serio
Externí odkaz:
https://doaj.org/article/fd0a800e45f947f787d63253bd19c82a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2463 (2023)
Next Generation Sequencing (NGS) technologies are rapidly entering clinical practice. A promising area for their use lies in the field of newborn screening. The mass screening of newborns using NGS technology leads to the discovery of a large number
Externí odkaz:
https://doaj.org/article/542f99927c1c44cda54225343754017f
Autor:
Alexey A. Lagunin, Anastasia V. Rudik, Pavel V. Pogodin, Polina I. Savosina, Olga A. Tarasova, Alexander V. Dmitriev, Sergey M. Ivanov, Nadezhda Y. Biziukova, Dmitry S. Druzhilovskiy, Dmitry A. Filimonov, Vladimir V. Poroikov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1689 (2023)
In vitro cell-line cytotoxicity is widely used in the experimental studies of potential antineoplastic agents and evaluation of safety in drug discovery. In silico estimation of cytotoxicity against hundreds of tumor cell lines and dozens of normal c
Externí odkaz:
https://doaj.org/article/8ae13d638cb64fbe9977835aa5ca41c7
Autor:
Eugene P. Kramarova, Sophia S. Borisevich, Edward M. Khamitov, Alexander A. Korlyukov, Pavel V. Dorovatovskii, Anastasia D. Shagina, Konstantin S. Mineev, Dmitri V. Tarasenko, Roman A. Novikov, Alexey A. Lagunin, Ivan Boldyrev, Aiarpi A. Ezdoglian, Natalia Yu. Karpechenko, Tatiana A. Shmigol, Yuri I. Baukov, Vadim V. Negrebetsky
Publikováno v:
Molecules, Vol 27, Iss 21, p 7542 (2022)
The synthesis of the products of the 1,3-propanesultone ring opening during its interaction with amides of pyridinecarboxylic acids has been carried out. The dependence of the yield of the reaction products on the position (ortho-, meta-, para-) of t
Externí odkaz:
https://doaj.org/article/080c465885b4411f8fc49211e013f536
Autor:
Denis A. Borozdenko, Aiarpi A. Ezdoglian, Tatiana A. Shmigol, Darya I. Gonchar, Dmitri N. Lyakhmun, Dmitri V. Tarasenko, Yaroslav V. Golubev, Elvira A. Cherkashova, Daria D. Namestnikova, Ilya L. Gubskiy, Alexey A. Lagunin, Leonid V. Gubsky, Vladimir P. Chekhonin, Sophia S. Borisevich, Maxim A. Gureev, Anastasia D. Shagina, Nina M. Kiseleva, Vadim V. Negrebetsky, Yuri I. Baukov
Publikováno v:
Molecules, Vol 26, Iss 20, p 6124 (2021)
We performed an in silico, in vitro, and in vivo assessment of a potassium 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl) acetamido]ethanesulfonate (compound 1) as a potential prodrug for cognitive function improvement in ischemic brain injury. Using in silico
Externí odkaz:
https://doaj.org/article/2b3a5471b2ee494e851c618e38e99ac8
Autor:
Alexander V. Dmitriev, Anastassia V. Rudik, Dmitry A. Karasev, Pavel V. Pogodin, Alexey A. Lagunin, Dmitry A. Filimonov, Vladimir V. Poroikov
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 538 (2021)
Drug–drug interactions (DDIs) can cause drug toxicities, reduced pharmacological effects, and adverse drug reactions. Studies aiming to determine the possible DDIs for an investigational drug are part of the drug discovery and development process a
Externí odkaz:
https://doaj.org/article/859be6f3d7664ecf89e76b3f8d5e9002