The Influence of Neurotrophic Factors BDNF and GDNF Overexpression on the Functional State of Mice and Their Adaptation to Audiogenic Seizures

Autor: Angelina O. Kustova, Maria S. Gavrish, Marina A. Sergeeva, Daria A. Avlasenko, Anna O. Kiseleva, Ekaterina A. Epifanova, Alexey A. Babaev, Tatiana A. Mishchenko, Maria V. Vedunova

Publikováno v: Brain Sciences, Vol 12, Iss 8, p 1039 (2022)

The high prevalence of diagnosed cases of severe neurological disorders, a significant proportion of which are epilepsy, contributes to a high level of mortality and disability in the population. Neurotrophic factors BDNF and GNDF are considered prom

Externí odkaz: https://doaj.org/article/86057363dd3f4d1690f26d22b1a67287

The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer’s Disease

Autor: Anna E. Bugrova, Polina A. Strelnikova, Maria I. Indeykina, Alexey S. Kononikhin, Natalia V. Zakharova, Alexander G. Brzhozovskiy, Evgeny P. Barykin, Stanislav I. Pekov, Maria S. Gavrish, Alexey A. Babaev, Anna M. Kosyreva, Anna Y. Morozova, Daniil A. Degterev, Vladimir A. Mitkevich, Igor A. Popov, Alexander A. Makarov, Evgeny N. Nikolaev

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 27, p 27 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 27
International Journal of Molecular Sciences

Alzheimer’s disease (AD) is the leading cause of dementia among the elderly. Neuropathologically, AD is characterized by the deposition of a 39- to 42-amino acid long β-amyloid (Aβ) peptide in the form of senile plaques. Several post-translationa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffe475c8cb636396fca66e715c3f2c5
https://www.mdpi.com/1422-0067/23/1/27

BDNF Overexpression Enhances the Preconditioning Effect of Brief Episodes of Hypoxia, Promoting Survival of GABAergic Neurons

Autor: Egor A. Turovsky, M V Vedunova, S. G. Gaidin, Alexey A. Babaev, M. V. Turovskaya

Publikováno v: Neuroscience Bulletin

Hypoxia causes depression of synaptic plasticity, hyperexcitation of neuronal networks, and the death of specific populations of neurons. However, brief episodes of hypoxia can promote the adaptation of cells. Hypoxic preconditioning is well manifest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ed8dd4227b79ebed0629a22ef83047
https://doi.org/10.1007/s12264-020-00480-z

Role of Satb1 and Satb2 Transcription Factors in the Glutamate Receptors Expression and Ca2+ Signaling in the Cortical Neurons In Vitro

Autor: Alexey A. Babaev, Elena G. Varlamova, Victor Tarabykin, E. I. Fedotova, Egor A. Turovsky, Maria V. Turovskaya

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 11; Pages: 5968
International Journal of Molecular Sciences, Vol 22, Iss 5968, p 5968 (2021)

Transcription factors Satb1 and Satb2 are involved in the processes of cortex development and maturation of neurons. Alterations in the expression of their target genes can lead to neurodegenerative processes. Molecular and cellular mechanisms of reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbba174f3d283fa1513a9fbbef5ae4a
http://europepmc.org/articles/PMC8198236

The selective BDNF overexpression in neurons protects neuroglial networks against OGD and glutamate-induced excitotoxicity

Autor: Alexey A. Babaev, S. G. Gaidin, M. V. Turovskaya, Egor A. Turovsky, E V Blinova, M S Gavrish, V.N. Mal'tseva

Publikováno v: The International journal of neuroscience. 130(4)

Objective: Cerebral ischemia is accompanied by damage and death of a significant number of neurons due to glutamate excitotoxicity with subsequent a global increase of cytosolic Ca2+ concentration ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ad617a33bc1d83938dc57c400af788
https://pubmed.ncbi.nlm.nih.gov/31694441