Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alexey A Ryakhovskiy"'
Autor:
Svetlana I Iarovenko, Karlsen Aa, Irina A. Leneva, Alexey A Ryakhovskiy, I A Potemkin, K. K. Kyuregyan, M. I. Mikhailov, Nadezhda P. Kartashova, Ekaterina A Glubokova
Publikováno v:
Acta virologica. 65:82-88
Hepatitis B virus (HBV) is a partially double-stranded DNA virus that specifically targets hepatocytes. It is considered a major health issue due to its high prevalence and the life-threatening consequences of chronic infection, including liver cirrh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07bf17de7ed9075a8175f2ca9582bf2
https://doi.org/10.4149/av_2021_110
https://doi.org/10.4149/av_2021_110
Autor:
Andrei A Ivashchenko, Ekaterina A Glubokova, Vladimir A. Aladinskiy, Dmitry V. Kravchenko, Oleg D. Mitkin, Alexander V Nikitin, Irina N. Falynskova, Ruben N. Karapetian, Jeremy C. Jones, Irina A. Leneva, Elena A. Govorkova, Alexey A Ryakhovskiy, Alexandre V. Ivachtchenko, Stephan V Mochalov, Angela G. Koryakova
Publikováno v:
J Antimicrob Chemother
Background The development and clinical implementation of the cap-dependent endonuclease (CEN) inhibitor baloxavir marboxil was a breakthrough in influenza therapy, but it was associated with the emergence of drug-resistant variants. Objectives To de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e406f12bf0e72827b4107f1547824b1
https://doi.org/10.1093/jac/dkaa524
https://doi.org/10.1093/jac/dkaa524
Autor:
Ruben N. Karapetian, Alexey A Ryakhovskiy, Alexander V Nikitin, Oleg D. Mitkin, Elena A. Govorkova, Angela G. Koryakova, Jeremy C. Jones, Irina A. Leneva, Ekaterina A Glubokova, Alexandre V. Ivachtchenko, Andrei A Ivashchenko, Dmitry V. Kravchenko, Vladimir A. Aladinskiy, Irina N. Falynskova
Publikováno v:
Journal of medicinal chemistry. 63(17)
4-Substituted 2,4-dioxobutanoic acids inhibit influenza virus cap-dependent endonuclease (CEN) activity. Baloxavir marboxil, 4, is approved for treating influenza virus infections. We describe here the synthesis and biological evaluation of active co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022d1a84b768d5321d984a772603a4c5
https://pubmed.ncbi.nlm.nih.gov/32787099
https://pubmed.ncbi.nlm.nih.gov/32787099
Autor:
Ivashchenko AA; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia.; ChemDiv, 6605 Nancy Ridge Drive, San Diego, California 92121, United States.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region 141700, Russia., Mitkin OD; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Jones JC; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Nikitin AV; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Koryakova AG; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Ryakhovskiy A; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Karapetian RN; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Kravchenko DV; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia., Aladinskiy V; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region 141700, Russia., Leneva IA; I. Mechnikov Research Institute for Vaccines and Sera, 5a Malyy Kazennyy Lane, Moscow 105064, Russia., Falynskova IN; I. Mechnikov Research Institute for Vaccines and Sera, 5a Malyy Kazennyy Lane, Moscow 105064, Russia., Glubokova EA; I. Mechnikov Research Institute for Vaccines and Sera, 5a Malyy Kazennyy Lane, Moscow 105064, Russia., Govorkova EA; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Ivachtchenko AV; Chemical Diversity Research Institute, Rabochaya Street 2a, Khimki, Moscow Region 141401, Russia.; ChemDiv, 6605 Nancy Ridge Drive, San Diego, California 92121, United States.; ASAVI LLC, 1835 E. Hallandale Beach Blvd, #442, Hallandale Beach, Florida 33009, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2020 Sep 10; Vol. 63 (17), pp. 9403-9420. Date of Electronic Publication: 2020 Aug 17.