Výsledky vyhledávání - "Alexey, Stukalov"

Akademický článek

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

Autor: Solène Denolly, Alexey Stukalov, Uladzimir Barayeu, Alina N. Rosinski, Paraskevi Kritsiligkou, Sebastian Joecks, Tobias P. Dick, Andreas Pichlmair, Ralf Bartenschlager

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close association with ER membranes. Here, we isolate ER membr

Externí odkaz: https://doaj.org/article/e994d1107b8b43ba817ee5beb730274a

Zobrazit plný text záznamu

Akademický článek

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Autor: Friederike L. Pennemann, Assel Mussabekova, Christian Urban, Alexey Stukalov, Line Lykke Andersen, Vincent Grass, Teresa Maria Lavacca, Cathleen Holze, Lila Oubraham, Yasmine Benamrouche, Enrico Girardi, Rasha E. Boulos, Rune Hartmann, Giulio Superti-Furga, Matthias Habjan, Jean-Luc Imler, Carine Meignin, Andreas Pichlmair

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)

Whether there are conserved nucleic acid (NA) binding proteins across species is not fully known. Using data from human, mouse and fly, the authors identify common binders, implicate TAOKs and show that these kinases bind NAs across species and promo

Externí odkaz: https://doaj.org/article/db868955f145422faefd0ca10f89353c

Zobrazit plný text záznamu

Akademický článek

Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)

Constant exposure of the airways to inhaled pathogens requires efficient early immune responses protecting against infections. How bacteria on the epithelial surface are detected and first-line protective mechanisms are initiated are not well underst

Externí odkaz: https://doaj.org/article/b6c462ddd8474b69bfe5c8500b0b830e

Zobrazit plný text záznamu

Akademický článek

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Autor: Sepideh Sadegh, Julian Matschinske, David B. Blumenthal, Gihanna Galindez, Tim Kacprowski, Markus List, Reza Nasirigerdeh, Mhaned Oubounyt, Andreas Pichlmair, Tim Daniel Rose, Marisol Salgado-Albarrán, Julian Späth, Alexey Stukalov, Nina K. Wenke, Kevin Yuan, Josch K. Pauling, Jan Baumbach

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Information developed to understand the molecular mechanisms of SARS-CoV-2 infection for predicting drug repurposing candidates is time-consuming to integrate and explore. Here, the authors develop an interactive online platform for virus-host intera

Externí odkaz: https://doaj.org/article/97cfd30dcc8f444386de8cedd10dff72

Zobrazit plný text záznamu

Akademický článek

dagLogo: An R/Bioconductor package for identifying and visualizing differential amino acid group usage in proteomics data.

Autor: Jianhong Ou, Haibo Liu, Niraj K Nirala, Alexey Stukalov, Usha Acharya, Michael R Green, Lihua Julie Zhu

Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0242030 (2020)

Sequence logos have been widely used as graphical representations of conserved nucleic acid and protein motifs. Due to the complexity of the amino acid (AA) alphabet, rich post-translational modification, and diverse subcellular localization of prote

Externí odkaz: https://doaj.org/article/bc19c1d0616c42f09877a83dd7390a44

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

In leukemia, diverse fusion proteins involving the MLL gene can drive oncogenic activity. Here, the authors describe a dependency of MLL-leukemia cells on the methyltransferase SETD2 to maintain genomic integrity during leukemia initiation and mainte

Externí odkaz: https://doaj.org/article/c65cecc9bf1145a685881a4d0ac0ba9d

Zobrazit plný text záznamu

Akademický článek

The alternative cap-binding complex is required for antiviral defense in vivo.

Autor: Anna Gebhardt, Valter Bergant, Daniel Schnepf, Markus Moser, Arno Meiler, Dieudonnée Togbe, Claire Mackowiak, Line S Reinert, Søren R Paludan, Bernhard Ryffel, Alexey Stukalov, Peter Staeheli, Andreas Pichlmair

Publikováno v: PLoS Pathogens, Vol 15, Iss 12, p e1008155 (2019)

Cellular response to environmental challenges requires immediate and precise regulation of transcriptional programs. During viral infections, this includes the expression of antiviral genes that are essential to combat the pathogen. Transcribed mRNAs

Externí odkaz: https://doaj.org/article/2f2f0378c45148fa99debb5c174e921a

Zobrazit plný text záznamu

Plný text ve formátu HTML

Vyhledávací nástroje:

Upřesnit hledání