Zobrazeno 1 - 10 of 67 pro vyhledávání: '"Alexey, Schulga"'
1
Akademický článek
On the prevention of kidney uptake of radiolabeled DARPins
Autor: Mohamed Altai, Javad Garousi, Sara S. Rinne, Alexey Schulga, Sergey Deyev, Anzhelika Vorobyeva
Publikováno v: EJNMMI Research, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Background Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14–18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of activity for DARPin
Externí odkaz: https://doaj.org/article/1cdec13355ae4c87aaae315f15791931
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2
Akademický článek
Accessing Mitochondrial Protein Import in Living Cells by Protein Microinjection
Autor: Andrey Bogorodskiy, Ivan Okhrimenko, Ivan Maslov, Nina Maliar, Dmitrii Burkatovskii, Florian von Ameln, Alexey Schulga, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Alexandros Katranidis, Ivan Sorokin, Alexey Mishin, Valentin Gordeliy, Georg Büldt, Wolfgang Voos, Thomas Gensch, Valentin Borshchevskiy
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondrial protein biogenesis relies almost exclusively on the expression of nuclear-encoded polypeptides. The current model postulates that most of these proteins have to be delivered to their final mitochondrial destination after their synthesis
Externí odkaz: https://doaj.org/article/16e2a2506edb4cd58990e060d3ca145f
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3
Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE)3-G3, for Imaging of HER2-Positive Breast Cancer
Autor: Tolmachev, Olga Bragina, Vladimir Chernov, Alexey Schulga, Elena Konovalova, Sophia Hober, Sergey Deyev, Jens Sörensen, Vladimir
Publikováno v: Cancers; Volume 15; Issue 12; Pages: 3149
Previous Phase I clinical evaluations of the radiolabelled scaffold proteins [99mTc]Tc-ADAPT6 and DARPin [99mTc]Tc-(HE)3-G3 in breast cancer patients have demonstrated their safety and indicated their capability to discriminate between HER2-positive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::5ada202882f2e7c5fd56faf546a66054
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5
Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model
Autor: Tianqi Xu, Alexey Schulga, Elena Konovalova, Sara S. Rinne, Hongchao Zhang, Olga Vorontsova, Anna Orlova, Sergey M. Deyev, Vladimir Tolmachev, Anzhelika Vorobyeva
Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2838
Pancreatic cancer (PC) is one of the most aggressive malignancies. A combination of targeted therapies could increase the therapeutic efficacy in tumors with heterogeneous target expression. Overexpression of the human epidermal growth factor recepto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e42011769d21b9384798a372733576
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-498128
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6
Direct In Vivo Comparison of 99mTc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy
Autor: Vorobyeva, Vladimir Tolmachev, Vitalina Bodenko, Maryam Oroujeni, Sergey Deyev, Elena Konovalova, Alexey Schulga, Sarah Lindbo, Sophia Hober, Olga Bragina, Anna Orlova, Anzhelika
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15181
Non-invasive radionuclide molecular visualization of human epidermal growth factor receptor type 2 (HER2) can provide stratification of patients for HER2-targeting therapy. This method can also enable monitoring of the response to such therapies, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::ed17c79fb261451ce7190e457bd1bada
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7
Akademický článek
Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1
Autor: Anzhelika Vorobyeva, Ekaterina Bezverkhniaia, Elena Konovalova, Alexey Schulga, Javad Garousi, Olga Vorontsova, Ayman Abouzayed, Anna Orlova, Sergey Deyev, Vladimir Tolmachev
Publikováno v: Molecules, Vol 25, Iss 20, p 4719 (2020)
Efficient treatment of disseminated triple-negative breast cancer (TNBC) remains an unmet clinical need. The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the surface of TNBC cells, which makes EpCAM a potential therapeutic targ
Externí odkaz: https://doaj.org/article/c156c6384f714624808c4eba38498ace
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9
Switchable targeting of solid tumors by BsCAR T cells
Autor: Alexey V. Stepanov, Roman S. Kalinin, Victoria O. Shipunova, Ding Zhang, Jia Xie, Yuri P. Rubtsov, Valeria M. Ukrainskaya, Alexey Schulga, Elena V. Konovalova, Dmitry V. Volkov, Igor A. Yaroshevich, Anastasiia M. Moysenovich, Alexey A. Belogurov, Hongkai Zhang, Georgij B. Telegin, Alexandr S. Chernov, Mikhail A. Maschan, Stanislav S. Terekhov, Peng Wu, Sergey M. Deyev, Richard A. Lerner, Alexander G. Gabibov, Sidney Altman
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(46)
The development of chimeric antigen receptor (CAR) T cell therapy has become a critical milestone in modern oncotherapy. Despite the remarkable in vitro effectiveness, the problem of safety and efficacy of CAR T cell therapy against solid tumors is c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b158f07f95cd0806ba54ba6223fbbdb
https://pubmed.ncbi.nlm.nih.gov/36343224
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10
Direct In Vivo Comparison of
Autor: Vladimir, Tolmachev, Vitalina, Bodenko, Maryam, Oroujeni, Sergey, Deyev, Elena, Konovalova, Alexey, Schulga, Sarah, Lindbo, Sophia, Hober, Olga, Bragina, Anna, Orlova, Anzhelika, Vorobyeva
Publikováno v: International journal of molecular sciences. 23(23)
Non-invasive radionuclide molecular visualization of human epidermal growth factor receptor type 2 (HER2) can provide stratification of patients for HER2-targeting therapy. This method can also enable monitoring of the response to such therapies, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f05ba8ec857a2107bc670dedd46acd14
https://pubmed.ncbi.nlm.nih.gov/36499504
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