Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Alexey, Rak"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are overexpressed in some tumor types. The antibody-drug conjugate tusamitamab ravtansine specifically recognizes the A3-B3 domains of human CEACAM5 (hCEACAM5). To understand
Externí odkaz:
https://doaj.org/article/f7fbe31decc84f1998df3899e41251c7
Autor:
Eduardo M. Bruch, Shaolong Zhu, Lisa Szymkowicz, Taylor Blake, Tara Kiss, D. Andrew James, Alexey Rak, Kartik Narayan, Matthew T. Balmer, Roman M. Chicz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, uses a surface expressed trimeric spike glycoprotein for cell entry. This trimer is the primary target for neutralizing antibodies making it
Externí odkaz:
https://doaj.org/article/6498d46d953a4bfcb0fc866354902992
Publikováno v:
SLAS Discovery. 26:1014-1019
The variety and complexity of drug targets are expanding rapidly. At the same time, there is significant interest in exploring a larger chemical space to identify new candidates. Fragment-based screening (FBS) has emerged as a popular alternative to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2982ef2c354ea72a6965013ab8a0174
https://doi.org/10.1177/24725552211026267
https://doi.org/10.1177/24725552211026267
Autor:
Jidong Zhang, Christine Lair, Christine Roubert, Kwame Amaning, María Belén Barrio, Yannick Benedetti, Zhicheng Cui, Zhongliang Xing, Xiaojun Li, Scott G. Franzblau, Nicolas Baurin, Florence Bordon-Pallier, Cathy Cantalloube, Stephanie Sans, Sandra Silve, Isabelle Blanc, Laurent Fraisse, Alexey Rak, Lasse B. Jenner, Gulnara Yusupova, Marat Yusupov, Junjie Zhang, Takushi Kaneko, T.J. Yang, Nader Fotouhi, Eric Nuermberger, Sandeep Tyagi, Fabrice Betoudji, Anna Upton, James C. Sacchettini, Sophie Lagrange
Publikováno v:
Cell. 186:1013-1025.e24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e45831acf54d672d5d43fbfea84a5e9
https://doi.org/10.1016/j.cell.2023.01.043
https://doi.org/10.1016/j.cell.2023.01.043
Publikováno v:
médecine/sciences. 35:1171-1174
De nos jours, la génération d’anticorps thérapeutiques doit être plus rapide avec des coûts de développement moins importants. Pour cela, des prédictions in silico sont associées à des technologies de criblage et de caractérisation de poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::738ace8a8b6af53c5725c765cb6bd178
https://doi.org/10.1051/medsci/2019232
https://doi.org/10.1051/medsci/2019232
Autor:
Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud
Publikováno v:
Journal of Medicinal Chemistry. 63:512-528
More than 75% of breast cancers are estrogen receptor alpha (ERα) positive (ER+), and resistance to current hormone therapies occurs in one-third of ER+ patients. Tumor resistance is still ERα-dependent, but mutations usually confer constitutive ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b8e31876cd3009f301f509589bd98
https://doi.org/10.1021/acs.jmedchem.9b01293
https://doi.org/10.1021/acs.jmedchem.9b01293
Autor:
Mathieu, Magali, Steier, Valérie, Fassy, Florence, Delorme, Cécile, Papin, David, Genet, Bruno, Duffieux, Francis, Bertrand, Thomas, Delarbre, Laure, Le-Borgne, Hélène, Parent, Annick, Didier, Patrick, Marquette, Jean-Pierre, Lowinski, Maryse, Houtmann, Jacques, Lamberton, Annabelle, Debussche, Laurent, Alexey, Rak
Publikováno v:
Small GTPases; December 2022, Vol. 13 Issue: 1 p225-238, 14p
Autor:
Derek J. Wilson, Stephen Li, Salvador F. Ausar, Thomas Bertrand, Jessica Duprez, Roger H. Brookes, Alexey Rak, D. Andrew James, Artur Pedyczak, Shaolong Zhu, Valerie Steier, Anthony Sheung, Michael X Cohen
Publikováno v:
Communications Biology
'Communications Biology ', vol: 3, pages: 427-1-427-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
'Communications Biology ', vol: 3, pages: 427-1-427-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
The mutant gdPT R9K/E129G is a genetically detoxified variant of the pertussis toxin (PTx) and represents an attractive candidate for the development of improved pertussis vaccines. The impact of the mutations on the overall protein structure and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c21e5acfc882add69441d72d08636b
http://europepmc.org/articles/PMC7406505
http://europepmc.org/articles/PMC7406505
Autor:
Jacques, Dumas, Anne, Sévérac, Cendrine, Lemoine, Sylvain, Huille, Alexey, Rak, Catherine, Prades
Publikováno v:
Medecine sciences : M/S. 35(12)
Therapeutic antibodies generation has to be faster with less development costs. This requires combination of in silico predictions associated with cutting edge screening and characterization technologies. Here, non-exhaustive examples illustrate this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae4e65a62e173e2d1f17735e196b6fd2
https://pubmed.ncbi.nlm.nih.gov/31903933
https://pubmed.ncbi.nlm.nih.gov/31903933
Publikováno v:
ChemMedChem. 14(11)
Ligand-based NMR screening represents a powerful method in fragment-based drug discovery for the identification of chemical matter interacting with the receptor of interest. The large dynamic range of these methods allows the detection of weakly bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587de28a599f936d0b2d9abcf687d763
https://pubmed.ncbi.nlm.nih.gov/30925009
https://pubmed.ncbi.nlm.nih.gov/30925009