Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Alexey, Obolensky"'
Autor:
Chen Matsevich, MSc, Prakadeeswari Gopalakrishnan, PhD, Alexey Obolensky, MD, PhD, Eyal Banin, MD, PhD, Dror Sharon, PhD, Avigail Beryozkin, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 1, Pp 100229- (2023)
Purpose: Pathogenic variants in FAM161A are the most common cause of retinitis pigmentosa in Israel. Two founder pathogenic variants explain the vast majority of cases of Jewish origin, 1 being a nonsense variant (p.Arg523∗). The aim of this study
Externí odkaz:
https://doaj.org/article/b00088d98ead49f984235a652f32a32d
Autor:
Avigail Beryozkin, Chen Matsevich, Alexey Obolensky, Corinne Kostic, Yvan Arsenijevic, Uwe Wolfrum, Eyal Banin, Dror Sharon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract FAM161A mutations are the most common cause of inherited retinal degenerations in Israel. We generated a knockout (KO) mouse model, Fam161a tm1b/tm1b , lacking the major exon #3 which was replaced by a construct that include LacZ under the e
Externí odkaz:
https://doaj.org/article/ad0c300bad8c4e92b277d31a4d21ab58
Autor:
Masha Idelson, Ruslana Alper, Alexey Obolensky, Nurit Yachimovich-Cohen, Jacob Rachmilewitz, Ayala Ejzenberg, Ekaterina Beider, Eyal Banin, Benjamin Reubinoff
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 681-695 (2018)
Summary: Age-related macular degeneration is caused by dysfunction and loss of retinal pigment epithelium (RPE) cells, and their transplantation may rescue visual functions and delay disease progression. Human embryonic stem cells (hESCs) may be an u
Externí odkaz:
https://doaj.org/article/ea02bed29ef34c968c8108304902d184
Autor:
Hamzah Aweidah, Chen Matsevich, Hanita Khaner, Masha Idelson, Ayala Ejzenberg, Benjamin Reubinoff, Eyal Banin, Alexey Obolensky
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be0a853ed679059576ae006c6787759
https://doi.org/10.1089/jop.2022.0161
https://doi.org/10.1089/jop.2022.0161
Autor:
Talya Millo, Antonio Rivera, Alexey Obolensky, Devora Marks-Ohana, Mingchu Xu, Yumei Li, Enosh Wilhelm, Prakadeeswari Gopalakrishnan, Menachem Gross, Boris Rosin, Mor Hanany, Andrew Webster, Anna Maria Tracewska, Robert K. Koenekoop, Rui Chen, Gavin Arno, Ora Schueler-Furman, Susanne Roosing, Eyal Banin, Dror Sharon
Publikováno v:
Genetics in Medicine, 24, 1523-1535
Genetics in Medicine, 24, 7, pp. 1523-1535
Genetics in Medicine, 24, 7, pp. 1523-1535
Item does not contain fulltext PURPOSE: This study aimed to investigate the clinical and genetic aspects of solute carrier (SLC) genes in inherited retinal diseases (IRDs). METHODS: Exome sequencing data were filtered to identify pathogenic variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2707f55251632b0d5b726a7c3a9a156e
https://hdl.handle.net/2066/282709
https://hdl.handle.net/2066/282709
Autor:
Victoria Peshti, Alexey Obolensky, Liat Nahum, Yariv Kanfi, Moran Rathaus, Maytal Avraham, Simon Tinman, Fredrick W Alt, Eyal Banin, Haim Y Cohen
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176371 (2017)
The NAD+-dependent SIRT6 deacetylase was shown to be a major regulator of lifespan and healthspan. Mice deficient for SIRT6 develop a premature aging phenotype and metabolic defects, and die before four weeks of age. Thus, the effect of SIRT6 deficie
Externí odkaz:
https://doaj.org/article/5828971d35ea408f88520d5c4681d65c
Autor:
Alaa Abu-Diab, Prakadeeswari Gopalakrishnan, Chen Matsevich, Marije de Jong, Alexey Obolensky, Ayat Khalaileh, Manar Salameh, Ayala Ejzenberg, Menachem Gross, Eyal Banin, Dror Sharon, Samer Khateb
Publikováno v:
Translational Vision Science & Technology. 12:3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9742e9074e4c4d90bf8e62d86e471a3d
https://doi.org/10.1167/tvst.12.3.3
https://doi.org/10.1167/tvst.12.3.3
Autor:
Chen, Matsevich, Prakadeeswari, Gopalakrishnan, Alexey, Obolensky, Eyal, Banin, Dror, Sharon, Avigail, Beryozkin
Publikováno v:
Ophthalmology science. 3(1)
Pathogenic variants inExperimental study of a mouse animal model.A total of 106HomozygousVisual and retinal function assessments, clinical imaging examinations, quantitative histology, and IHC studies of KI as compared with wild-type (WT) mice retina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b74c7de1918c6354d920a134f5610fe5
https://pubmed.ncbi.nlm.nih.gov/36420180
https://pubmed.ncbi.nlm.nih.gov/36420180
Autor:
Mor Hanany, Hadas Newman, Tamar Ben-Yosef, Eedy Mezer, Frans P.M. Cremers, Eyal Banin, Alexey Obolensky, Itay Chowers, Samer Khateb, Muhammad Imran Khan, Avigail Beryozkin, Dror Sharon, Carlos Alberto Idrobo-Robalino
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, 10, 1
Scientific Reports, 10
Scientific Reports
Scientific Reports, 10, 1
Scientific Reports, 10
Scientific Reports
FAM161A mutations are the most common cause of autosomal recessive retinitis pigmentosa in the Israeli-Jewish population. We aimed to characterize the spectrum of FAM161A-associated phenotypes and identify characteristic clinical features. We identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827c9bb9588d9d53c56e9c32f3396dfa
http://link.springer.com/article/10.1038/s41598-020-72028-0
http://link.springer.com/article/10.1038/s41598-020-72028-0
Autor:
Esther Yamin, Elisha Gootwine, Alexey Obolensky, Eyal Banin, Raaya Ezra-Elia, Edward Averbukh, Ron Ofri, William W. Hauswirth, Hay Dvir, Maya Ross, Hen Honig, Alexander Rosov
Publikováno v:
Human Gene Therapy. 31:719-729
Gene augmentation therapy based on subretinal delivery of adeno-associated viral (AAV) vectors is proving to be highly efficient in treating several inherited retinal degenerations. However, due to potential complications and drawbacks posed by subre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818d5537ca37d9c1e347b78eb1fc0401
https://doi.org/10.1089/hum.2020.023
https://doi.org/10.1089/hum.2020.023