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Akademický článek
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Autor:
Caitlin Sedwick
Publikováno v:
The Journal of Cell Biology
Situated at either end of the animal mitotic spindle, centrosomes are one of the most prominent and visually striking features of the mitotic apparatus. But what, exactly, is their function in cell division? And how is the mitotic spindle organized i
Autor:
Fioranna Renda, Alexey Khodjakov
Publikováno v:
Current Biology. 33:R187-R190
Akademický článek
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Autor:
Fioranna Renda, Valentin Magidson, Irina Tikhonenko, Rebecca Fisher, Christopher Miles, Alex Mogilner, Alexey Khodjakov
Publikováno v:
Open Biology, Vol 10, Iss 7 (2020)
The distance between fluorescent spots formed by various kinetochore proteins (delta) is commonly interpreted as a manifestation of intrakinetochore tension (IKT) caused by microtubule-mediated forces. However, large-scale changes of the kinetochore
Externí odkaz:
https://doaj.org/article/0ca8e3c7b5ab4f1fb9b7f1b1cca500d7
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(39)
Chromosome segregation requires load-bearing interactions across kinetochore fibers and antiparallel microtubule bundles, which constitute the spindle midzone. Mechanical properties of kinetochore fibers have been characterized during metaphase, when
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::171f47d274fdc750e0d9fb9839cb9a2e
https://doi.org/10.1007/978-1-0716-2639-9_31
https://doi.org/10.1007/978-1-0716-2639-9_31
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2557
The vertebrate Golgi complex is a large dynamic organelle which undergoes morphological changes and fragmentation both as a part of normal physiological dynamics and under disease conditions. The Golgi is known to have a functionally important relati
Autor:
Keyada Frye, Fioranna Renda, Maria Fomicheva, Xiaodong Zhu, Lisa Gong, Alexey Khodjakov, Irina Kaverina
Publikováno v:
Cells, Vol 9, Iss 5, p 1069 (2020)
Here, we characterize spatial distribution of the Golgi complex in human cells. In contrast to the prevailing view that the Golgi compactly surrounds the centrosome throughout interphase, we observe characteristic differences in the morphology of Gol
Externí odkaz:
https://doaj.org/article/f86187997a164a209abbdd350221813b
Autor:
Fioranna Renda, Alexey Khodjakov
Publikováno v:
Seminars in cell & developmental biology
Mitotic spindle is a self-assembling macromolecular machine responsible for the faithful segregation of chromosomes during cell division. Assembly of the spindle is believed to be governed by the ‘Search & Capture’ (S&C) principle in which dynami