Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexey, Bulychev"'
Autor:
Yuanjing Liu, Amy Andreucci, Naoki Iwamoto, Yuan Yin, Hailin Yang, Fangjun Liu, Alexey Bulychev, Xiao Shelley Hu, Xuena Lin, Sarah Lamore, Saurabh Patil, Susovan Mohapatra, Erin Purcell-Estabrook, Kristin Taborn, Elena Dale, Chandra Vargeese
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 558-570 (2022)
A large hexanucleotide (G4C2) repeat expansion in the first intronic region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Several mechanisms have been proposed to explain how the
Externí odkaz:
https://doaj.org/article/abb85617456d47dc9e93f622cb10832e
Autor:
Yuanjing, Liu, Amy, Andreucci, Naoki, Iwamoto, Yuan, Yin, Hailin, Yang, Fangjun, Liu, Alexey, Bulychev, Xiao Shelley, Hu, Xuena, Lin, Sarah, Lamore, Saurabh, Patil, Susovan, Mohapatra, Erin, Purcell-Estabrook, Kristin, Taborn, Elena, Dale, Chandra, Vargeese
Publikováno v:
Molecular therapy. Nucleic acids. 28
A large hexanucleotide (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d025dde90c1ac7eac62c6d4b93c520b9
https://pubmed.ncbi.nlm.nih.gov/35592494
https://pubmed.ncbi.nlm.nih.gov/35592494
Autor:
Ann J. Stemmler, Shahriar Mobashery, Dasantila Golemi-Kotra, Sergei B. Vakulenko, Choonkeun Kim, Samy O. Meroueh, Timothy L. Stemmler, Alexey Bulychev
Publikováno v:
Journal of Biological Chemistry. 279:34665-34673
Beta-lactamases and penicillin-binding proteins are bacterial enzymes involved in antibiotic resistance to beta-lactam antibiotics and biosynthetic assembly of cell wall, respectively. Members of these large families of enzymes all experience acylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd3132aa910783e762961c120976375
https://doi.org/10.1074/jbc.m313143200
https://doi.org/10.1074/jbc.m313143200
Autor:
Peter Swarén, Shahriar Mobashery, Stéphanie Cabantous, Jean-Pierre Samama, Alexey Bulychev, Laurent Maveyraud, Dasantila Golemi
Publikováno v:
Biochemistry. 38:9570-9576
The clinical use of beta-lactam antibiotics combined with beta-lactamase inactivators, such as clavulanate, has resulted in selection of beta-lactamases that are insensitive to inactivation by these molecules. Therefore, therapeutic combinations of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2d24146d7e8df9551bca0ec70edaec
https://doi.org/10.1021/bi990758z
https://doi.org/10.1021/bi990758z
Publikováno v:
Journal of the American Chemical Society. 120:13003-13007
Hydrogen bonds between a small molecule and an enzyme can potentially contribute significantly to the stability of the complex. Such electrostatic interactions can also lower energy barriers for reactions by solvation of high-energy species. A novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99843817d3199fef9c1a02eb35ceb208
https://doi.org/10.1021/ja983063e
https://doi.org/10.1021/ja983063e
Publikováno v:
Journal of the American Chemical Society. 119:7619-7625
β-Lactamases of classes A and C are believed to have evolved from bacterial enzymes involved in biosynthesis of the peptidoglycan, the so-called penicillin-binding proteins. All these enzymes undergo acylation at an active-site serine by β-lactam a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5be1ec87381646a377e42718e568fbb2
https://doi.org/10.1021/ja963708f
https://doi.org/10.1021/ja963708f
Autor:
Michael E. O'Brien, Irina Massova, Alexey Bulychev, Min Teng, Marvin J. Miller, Shahriar Mobashery, Tracy A. Gibson
Publikováno v:
Journal of the American Chemical Society. 117:5938-5943
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf83959f0bd8158130ba4298cfeca3b
https://doi.org/10.1021/ja00127a005
https://doi.org/10.1021/ja00127a005
Publikováno v:
Journal of the American Chemical Society. 117:4797-4801
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::347886bcf71681c28ad954c40f9f75ac
https://doi.org/10.1021/ja00122a009
https://doi.org/10.1021/ja00122a009
Autor:
Brian F.P. Edwards, M. A. Doyle, R. Kocz, Irina Massova, Philip D. Martin, Shahriar Mobashery, Alexey Bulychev
Publikováno v:
ChemInform. 30
The program DOCK was used to search for novel inhibitors for α-thrombin. Four among the top twelve best scoring compounds from the Cambridge Structural Data Base inhibited this enzyme, and three of them inhibited α-thrombin in a competitive mode. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f780b20b6fab1153a635bad891a66233
https://doi.org/10.1002/chin.199902261
https://doi.org/10.1002/chin.199902261
Publikováno v:
FEBS Letters. 487:298-300
A predominant conformational isomer of non-native alpha-lactalbumin (alpha-LA) has been purified by thermal denaturation of the native alpha-LA using the technique of disulfide scrambling. This unique isomer retains a substantial content of alpha-hel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c5c25eeab7626e6c601ea45c544598
https://doi.org/10.1016/s0014-5793(00)02341-3
https://doi.org/10.1016/s0014-5793(00)02341-3