Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Alexej Abyzov"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, termed NC0. Here, by sequencing the genome of
Externí odkaz:
https://doaj.org/article/9ce9af2626494b6fa20ba8bafc56857f
Autor:
Davide Capauto, Yifan Wang, Feinan Wu, Scott Norton, Jessica Mariani, Fumitaka Inoue, Gregory E. Crawford, Nadav Ahituv, Alexej Abyzov, Flora M. Vaccarino
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Regulation of gene expression through enhancers is one of the major processes shaping the structure and function of the human brain during development. High-throughput assays have predicted thousands of enhancers involved in neurodevelopment
Externí odkaz:
https://doaj.org/article/ca2e76102a6a4aa197468ba562562414
Autor:
McKinzie A. Garrison, Yeongjun Jang, Taejeong Bae, Adriana Cherskov, Sarah B. Emery, Liana Fasching, Attila Jones, John B. Moldovan, Cindy Molitor, Sirisha Pochareddy, Mette A. Peters, Joo Heon Shin, Yifan Wang, Xiaoxu Yang, Schahram Akbarian, Andrew Chess, Fred H. Gage, Joseph G. Gleeson, Jeffrey M. Kidd, Michael McConnell, Ryan E. Mills, John V. Moran, Peter J. Park, Nenad Sestan, Alexander E. Urban, Flora M. Vaccarino, Christopher A. Walsh, Daniel R. Weinberger, Sarah J. Wheelan, Alexej Abyzov, BSMN Consortium
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-18 (2023)
Abstract Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that p
Externí odkaz:
https://doaj.org/article/169288af9ac84d8b8a7875b0a5f4336c
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 12, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/386a92efee7f41f78b11dfd8bcb21062
Autor:
Yifan Wang, Taejeong Bae, Jeremy Thorpe, Maxwell A. Sherman, Attila G. Jones, Sean Cho, Kenneth Daily, Yanmei Dou, Javier Ganz, Alon Galor, Irene Lobon, Reenal Pattni, Chaggai Rosenbluh, Simone Tomasi, Livia Tomasini, Xiaoxu Yang, Bo Zhou, Schahram Akbarian, Laurel L. Ball, Sara Bizzotto, Sarah B. Emery, Ryan Doan, Liana Fasching, Yeongjun Jang, David Juan, Esther Lizano, Lovelace J. Luquette, John B. Moldovan, Rujuta Narurkar, Matthew T. Oetjens, Rachel E. Rodin, Shobana Sekar, Joo Heon Shin, Eduardo Soriano, Richard E. Straub, Weichen Zhou, Andrew Chess, Joseph G. Gleeson, Tomas Marquès-Bonet, Peter J. Park, Mette A. Peters, Jonathan Pevsner, Christopher A. Walsh, Daniel R. Weinberger, Brain Somatic Mosaicism Network, Flora M. Vaccarino, John V. Moran, Alexander E. Urban, Jeffrey M. Kidd, Ryan E. Mills, Alexej Abyzov
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Background Post-zygotic mutations incurred during DNA replication, DNA repair, and other cellular processes lead to somatic mosaicism. Somatic mosaicism is an established cause of various diseases, including cancers. However, detecting mosai
Externí odkaz:
https://doaj.org/article/ed8ec2a7cb594e94ba5848bb9fd9be5a
Autor:
Vivekananda Sarangi, Yeongjun Jang, Milovan Suvakov, Taejeong Bae, Liana Fasching, Shobana Sekar, Livia Tomasini, Jessica Mariani, Flora M Vaccarino, Alexej Abyzov
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1009487 (2022)
Accurate discovery of somatic mutations in a cell is a challenge that partially lays in immaturity of dedicated analytical approaches. Approaches comparing a cell's genome to a control bulk sample miss common mutations, while approaches to find such
Externí odkaz:
https://doaj.org/article/848e1df22c1148058be996edd1e34985
Autor:
Vivekananda Sarangi, Alexandre Jourdon, Taejeong Bae, Arijit Panda, Flora Vaccarino, Alexej Abyzov
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background The study of mosaic mutation is important since it has been linked to cancer and various disorders. Single cell sequencing has become a powerful tool to study the genome of individual cells for the detection of mosaic mutations. T
Externí odkaz:
https://doaj.org/article/cd6217f209ad4b1388d55e6f16d05504
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background High-resolution microarray technology is routinely used in basic research and clinical practice to efficiently detect copy number variants (CNVs) across the entire human genome. A new generation of arrays combining high probe dens
Externí odkaz:
https://doaj.org/article/b725446d226b40d4b6fff08d4033df41
Autor:
Brooke R. Druliner, Shahrooz Rashtak, Xiaoyang Ruan, Taejeong Bae, Nikolaos Vasmatzis, Daniel O’Brien, Ruth Johnson, Donna Felmlee-Devine, Jill Washechek-Aletto, Nivedita Basu, Hongfang Liu, Thomas Smyrk, Alexej Abyzov, Lisa A. Boardman
Publikováno v:
Translational Oncology, Vol 9, Iss 4, Pp 280-286 (2016)
The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesi
Externí odkaz:
https://doaj.org/article/e619ad9ac3df4e22af54686a3c958750
Autor:
Jieming Chen, Joel Rozowsky, Timur R. Galeev, Arif Harmanci, Robert Kitchen, Jason Bedford, Alexej Abyzov, Yong Kong, Lynne Regan, Mark Gerstein
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Using variants from the 1000 Genomes Project, RNA-seq and ChIP-seq data from related projects, this study describes a resource and survey of allele-specific binding and gene expression. A catalogue of allelic SNPs and annotation elements is available
Externí odkaz:
https://doaj.org/article/d440bca1c75048d0a733a3fb0a6a9ba5