Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Alexei V. Buevich"'
Publikováno v:
Molecules, Vol 28, Iss 9, p 3796 (2023)
Natural products remain one of the major sources of coveted, biologically active compounds. Each isolated compound undergoes biological testing, and its structure is usually established using a set of spectroscopic techniques (NMR, MS, UV-IR, ECD, VC
Externí odkaz:
https://doaj.org/article/0b860ce77840471e92c4745ed470751a
Autor:
Ryan D. Cohen, Jared S. Wood, Yu-Hong Lam, Alexei V. Buevich, Edward C. Sherer, Mikhail Reibarkh, R. Thomas Williamson, Gary E. Martin
Publikováno v:
Molecules, Vol 28, Iss 6, p 2449 (2023)
Density functional theory (DFT) benchmark studies of 1H and 13C NMR chemical shifts often yield differing conclusions, likely due to non-optimal test molecules and non-standardized data acquisition. To address this issue, we carefully selected and me
Externí odkaz:
https://doaj.org/article/54ed81ada0c14c79b1a03ce3cb2aa001
Autor:
Alice Trac, Célia Issaad, Mehdi A. Beniddir, Jean-Michel Bellanger, Jean-François Gallard, Alexei V. Buevich, Mikhail E. Elyashberg, Pierre Le Pogam
Publikováno v:
Molecules, Vol 28, Iss 4, p 1557 (2023)
The UHPLC–HRMS analysis of Cortinarius ominosus basidiomata extract revealed that this mushroom accumulated elevated yields of an unreported specialized metabolite. The molecular formula of this unknown compound, C17H10O8, indicated that a challeng
Externí odkaz:
https://doaj.org/article/4a9690bcb9dd481289f67450ef49b9a1
Autor:
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang
Publikováno v:
Journal of Medicinal Chemistry. 65:16234-16251
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection. Concurrent with our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72a226d0f459e4620537979c8da4d4d
https://doi.org/10.1021/acs.jmedchem.2c00766
https://doi.org/10.1021/acs.jmedchem.2c00766
Autor:
Shane W. Krska, Sriram Tyagarajan, Deodial Guiadeen, Eric Streckfuss, Xiaolei Gao, Alexei V. Buevich, George Doss, Jian Liu, Petr Vachal
Publikováno v:
Synlett. 33:1259-1265
Late-stage functionalization (LSF) enables medicinal chemists to quickly explore structure–activity relationships (SAR) of novel analogues derived from a fully elaborated parent structure. Using several known C–H functionalization chemistries, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93fa372b4b2a7b9f22bfd3c4fdcca4e7
https://doi.org/10.1055/s-0040-1719923
https://doi.org/10.1055/s-0040-1719923
Autor:
Mihirbaran Mandal, Maria Madeira, Rupesh P. Amin, Alexei V. Buevich, Alan Cheng, Marc Labroli, Xiaoxiang Liu, John Acton, Barbara Pio, Andrea Basso, Harry Chobanian, Grace Dong, Jamie Dropinski, Yan Guo, Zhuyan Guo, Stan Kurowski, Walter Korfmacher, Sandra Lee, Dongfang Meng, Debra Ondeyka, Zhiqiang Yang, Rumin Zhang, Huijun Wei, Zhicai Wu, Fengqi Zhang, Gordon Wollenberg, Tesfaye Biftu, William J. Greenlee, Madhu Chintala, Milana Maletic, Zhaoning Zhu
Publikováno v:
Journal of Medicinal Chemistry. 65:5575-5592
Vorapaxar is an approved drug for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction or with peripheral arterial disease. Subsequent to the discovery of Vorapaxar, medicinal chemistry efforts were co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d0e58362d38a85e8d5aef1a3cbe66a
https://doi.org/10.1021/acs.jmedchem.1c02048
https://doi.org/10.1021/acs.jmedchem.1c02048
Autor:
Alexei V. Buevich, Cyndi Qixin He, Barbara Pio, Koppara Samuel, Kaushik Mitra, Edward C. Sherer, Mark T. Cancilla, Harry R. Chobanian
Publikováno v:
Chemical Research in Toxicology. 35:459-474
Acyl glucuronide (AG) metabolites of carboxylic acid-containing drugs and products of their transformations have long been implicated in drug-induced liver injury (DILI). To inform on the DILI risk arising from AG reactive intermediates, a comprehens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee89dbb279ea38c06843b7ee0b86434
https://doi.org/10.1021/acs.chemrestox.1c00366
https://doi.org/10.1021/acs.chemrestox.1c00366
Autor:
Gregory L. Adams, Parul S. Pall, Steven M. Grauer, Xiaoping Zhou, Jeanine E. Ballard, Marissa Vavrek, Richard L. Kraus, Pierre Morissette, Nianyu Li, Stefania Colarusso, Elisabetta Bianchi, Anandan Palani, Rebecca Klein, Christopher T. John, Deping Wang, Matthew Tudor, Andrew F. Nolting, Mirlinda Biba, Timothy Nowak, Alexey A. Makarov, Mikhail Reibarkh, Alexei V. Buevich, Wendy Zhong, Erik L. Regalado, Xiao Wang, Qi Gao, Aurash Shahripour, Yuping Zhu, Daniele de Simone, Tommaso Frattarelli, Nicolo’ Maria Pasquini, Paola Magotti, Roberto Iaccarino, Yuxing Li, Kelli Solly, Keun-Joong Lee, Weixun Wang, Feifei Chen, Haoyu Zeng, Jixin Wang, Hilary Regan, Rupesh P. Amin, Christopher P. Regan, Christopher S. Burgey, Darrell A. Henze, Chengzao Sun, David M. Tellers
Publikováno v:
Journal of Medicinal Chemistry. 65:485-496
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ecd04283fe1d38ba43c9ca77818a20e
https://doi.org/10.1021/acs.jmedchem.1c01570
https://doi.org/10.1021/acs.jmedchem.1c01570
Autor:
Michael Frey, Marius Pelmuş, R. Thomas Williamson, Gary E. Martin, Mikhail Reibarkh, Alexei V. Buevich, Evgeny Tischenko, Jeffrey G. Raab, Ronald C. Crouch
Publikováno v:
Magnetic Resonance in Chemistry. 60:210-220
Modification of the recently reported 19 F-detected 1,1-ADEQUATE experiment that incorporates dual-optimization to selectively invert a wide range of 1 JCC correlations in a 1,n-ADEQUATE experiment is reported. Parameters for the dual-optimization se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56c7fed7d582eb1be2e3cc1f56e108e5
https://doi.org/10.1002/mrc.5215
https://doi.org/10.1002/mrc.5215
Autor:
Mckittrick Brian A, Mihirbaran Mandal, Jared N. Cumming, Andrew Brunskill, Andrew Stamford, Hongwu Wang, Xiaoxiang Liu, Alexei V. Buevich, Robert Mazzola, Peter Orth, Zhaoning Zhu, John P. Caldwell
Publikováno v:
European Journal of Organic Chemistry. 2021:5073-5079
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df583a27443bdf99ebdd82d44726c381
https://doi.org/10.1002/ejoc.202101056
https://doi.org/10.1002/ejoc.202101056