Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Alexei V, Tumanov"'
Autor:
George T. Naratadam, Jennifer Mecklenburg, Sergey A. Shein, Yi Zou, Zhao Lai, Alexei V. Tumanov, Theodore J. Price, Armen N. Akopian
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract This study investigated the time course of gene expression changes during the progression of persistent painful neuropathy caused by paclitaxel (PTX) in male and female mouse hindpaws and dorsal root ganglia (DRG). Bulk RNA-seq was used to e
Externí odkaz:
https://doaj.org/article/2879d39e45dd414fbd289733bac85680
Autor:
Karen A. Lindquist, Sergey A. Shein, Anahit H. Hovhannisyan, Jennifer Mecklenburg, Yi Zou, Zhao Lai, Alexei V. Tumanov, Armen N. Akopian
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Gene plasticity during myogenous temporomandibular disorder (TMDM) development is largely unknown. TMDM could be modeled by intramuscular inflammation or tissue damage. To model inflammation induced TMDM we injected complete Freund’s adjuv
Externí odkaz:
https://doaj.org/article/dffa3764714242e38fb81deea8ebd5d7
LTβR-RelB signaling in intestinal epithelial cells protects from chemotherapy-induced mucosal damage
Autor:
Qiangxing Chen, Amanda R. Muñoz, Anna A. Korchagina, Yajun Shou, Jensine Vallecer, Austin W. Todd, Sergey A. Shein, Alexei V. Tumanov, Ekaterina Koroleva
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The intricate immune mechanisms governing mucosal healing following intestinal damage induced by cytotoxic drugs remain poorly understood. The goal of this study was to investigate the role of lymphotoxin beta receptor (LTβR) signaling in chemothera
Externí odkaz:
https://doaj.org/article/fb721f23fb2f4fdea0518dae6d6f8b74
Autor:
Tarek Ibrahim, Ping Wu, Li-Ju Wang, Chang Fang-Mei, Josue Murillo, Jaclyn Merlo, Sergey S. Shein, Alexei V. Tumanov, Zhao Lai, Korri Weldon, Yidong Chen, Shivani Ruparel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Mechanisms of sex-dependent orofacial pain are widely understudied. A significant gap in knowledge exists about comprehensive regulation of tissue-specific trigeminal sensory neurons in diseased state of both sexes. Using RNA sequencing of F
Externí odkaz:
https://doaj.org/article/79d7679fdfd14c77bc043fef711445ae
Autor:
Jennifer Mecklenburg, Sergey A. Shein, Mostafa Malmir, Anahit H. Hovhannisyan, Korri Weldon, Yi Zou, Zhao Lai, Yu-Fang Jin, Shivani Ruparel, Alexei V. Tumanov, Armen N. Akopian
Publikováno v:
Frontiers in Pain Research, Vol 4 (2023)
Non-neuronal cells constitute 90%–95% of sensory ganglia. These cells, especially glial and immune cells, play critical roles in the modulation of sensory neurons. This study aimed to identify, profile, and summarize the types of trigeminal ganglio
Externí odkaz:
https://doaj.org/article/b182bf650a4f4b94b25636cc5b778b47
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Innate lymphoid cells (ILCs) are heterogeneous innate immune cells which participate in host defense, mucosal repair and immunopathology by producing effector cytokines similarly to their adaptive immune cell counterparts. The development of ILC1, 2,
Externí odkaz:
https://doaj.org/article/51525d82e5464818bf01e907077adde7
Autor:
Anahit H. Hovhannisyan, Hyeonwi Son, Jennifer Mecklenburg, Priscilla Ann Barba-Escobedo, Meilinn Tram, Ruben Gomez, John Shannonhouse, Yi Zou, Korri Weldon, Shivani Ruparel, Zhao Lai, Alexei V. Tumanov, Yu Shin Kim, Armen N. Akopian
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Trigeminal (TG), dorsal root (DRG), and nodose/jugular (NG/JG) ganglia each possess specialized and distinct functions. We used RNA sequencing of two-cycle sorted Pirt-positive neurons to identify genes exclusively expressing in L3–L5 DRG,
Externí odkaz:
https://doaj.org/article/0068e9c9db544ba09762a26e0082f949
Autor:
Yuejin Liang, James Fisher, Casey Gonzales, Brandon Trent, Galen Card, Jiaren Sun, Alexei V. Tumanov, Lynn Soong
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Infection with Orientia tsutsugamushi, an obligate intracellular bacterium, can cause mild or severe scrub typhus. Some patients develop acute lung injury, multi-organ failure, and fatal infection; however, little is known regarding key immune mediat
Externí odkaz:
https://doaj.org/article/6b3354bce1824cd8b16bb1691c6ed286
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 461 (2023)
Mucosal tissue homeostasis is a dynamic process that involves multiple mechanisms including regulation of innate lymphoid cells (ILCs). ILCs are mostly tissue-resident cells which are critical for tissue homeostasis and immune response against pathog
Externí odkaz:
https://doaj.org/article/aaab62d90d3b4e5991289c3e131ab44f
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Innate lymphoid cells (ILCs) are a heterogeneous group of cytokine-producing lymphocytes which are predominantly located at mucosal barrier surfaces, such as skin, lungs, and gastrointestinal tract. ILCs contribute to tissue homeostasis, regulate mic
Externí odkaz:
https://doaj.org/article/3896c3d779934de489bb5288898aeb27