Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Alexei Terman"'
Autor:
Alexei Terman, Wilhelm Graf, Helgi Birgisson, Peter H Cashin, Johan Botling, Lana Ghanipour, Malin Enblad
Publikováno v:
Annals of Surgical Oncology. 27:293-300
Background KRAS and BRAF mutations are prognostic and predictive tools in metastatic colorectal cancer, but little is known about their prognostic value in patients scheduled for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemothera
Autor:
Malin Enblad, Wilhelm Graf, Anders Isaksson, Helgi Birgisson, Alexei Terman, Pascal Pucholt, Björn Viklund
Publikováno v:
Annals of Surgical Oncology
Purpose Genetic alterations in colorectal peritoneal metastases (PM) are largely unknown. This study was designed to analyze whole-genome copy number alterations (CNA) in colorectal PM and to identify alterations associated with prognosis after cytor
Autor:
Jochen M. Schwenk, Rainer Heuchel, Johan Permert, Burcu Ayoglu, Sam Ghazi, Isabelle Magalhaes, Brigitta Omazic, Markus Maeurer, Jonas Mattsson, Zuzana Potácová, Ralf Segersvärd, Nils Albiin, Liu Zhenjiang, Thomas Poiret, Caroline S. Verbeke, Peter Nilsson, Matthias Löhr, Alexei Terman, Olle Ringdén, Nikolaos Kartalis
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997). 40(4)
We examined the immunologic effects of allogeneic hematopoietic stem cell transplantation (HSCT) in the treatment of pancreatic ductal adenocarcinoma, a deadly disease with a median survival of 24 months for resected tumors and a 5-year survival rate
Autor:
Angel Cedazo-Minguez, Alexei Terman, Martin Hallbeck, Javier Calvo-Garrido, Kjell Hultenby, Lin Zheng, Jan Marcusson
Publikováno v:
Journal of Alzheimer's Disease. 37:713-733
Amyloid-β peptide (Aβ), the main component of Alzheimer's disease (AD) senile plaques, has been found to accumulate within the lysosomal compartment of AD neurons. We have previously shown that in differentiated SH-SY5Y neuroblastoma cells cultured
Autor:
Tino Kurz, Alexei Terman
Publikováno v:
Antioxidants & Redox Signaling. 18:888-898
Lysosomes are acidic organelles containing more than fifty hydrolases that provide for the degradation of intracellular and endocytosed materials by autophagy and heterophagy, respectively. They digest a variety of macromolecules, as well as all orga
Publikováno v:
Antioxidants & Redox Signaling. 12:503-535
It is now generally accepted that aging and eventual death of multicellular organisms is to a large extent related to macromolecular damage by mitochondrially produced reactive oxygen species, mostly affecting long-lived postmitotic cells, such as ne
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1780:1291-1303
The lysosomal compartment consists of numerous acidic vesicles (pH approximately 4-5) that constantly fuse and divide. It receives a large number of hydrolases from the trans-Golgi network, while their substrates arrive from both the cell's outside (
Publikováno v:
Current Cardiology Reviews
The myocardium is mainly composed of long-lived postmitotic cells with, if there is any at all, a very low rate of replacement through the division and differentiation of stem cells. As a consequence, cardiac myocytes gradually undergo pronounced age
Publikováno v:
Experimental Cell Research. 314:164-172
Giant mitochondria accumulate within aged or diseased postmitotic cells as a consequence of insufficient autophagy, which is normally responsible for mitochondrial degradation. We report that giant mitochondria accumulating in cultured rat myoblasts
Publikováno v:
The Journal of Pathology. 211:134-143
As a result of insufficient digestion of oxidatively damaged macromolecules and organelles by autophagy and other degradative systems, long-lived postmitotic cells, such as cardiac myocytes, neurons and retinal pigment epithelial cells, progressively