Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alexei O, Vassilev"'
Autor:
Taracad K. Venkatachalam, Douglas Erbeck, Fatih M. Uckun, Xing-Ping Liu, Sanjive Qazi, Ilker Dibirdik, Heather E. Tibbles, Alexei O. Vassilev
Publikováno v:
Arzneimittelforschung. 54:715-731
The novel cytotoxic nucleoside analog Compound 003 (3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate], CAS 149560-32-7) prevented bipolar mitotic spindle assembly and caused a G2 arrest in human cancer cells. Compound 003 was very well
Autor:
Suzanne Downs, Olga O. Grigoriants, Alexey Benyumov, Alexei O. Vassilev, Taracad K. Venkatachalam, Darin Dumezb, Fatih M. Uckun, Heather E. Tibbles
Publikováno v:
Arzneimittelforschung. 55:114-122
The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryoni
Autor:
Fatih M. Uckun, Alexei O. Vassilev, Douglas Erbeck, Sanjive Qazi, Taracad K. Venkatachalam, Heather E. Tibbles
Publikováno v:
Arzneimittelforschung. 57:320-329
Familial adenomatous polyposis (FAP) is associated with germ-line mutations in the tumor suppressor gene, adenomatous polyposis coli (APC) located on chromosome 5q21. Multiple intestinal neoplasia (Min) in mice resembles FAP in humans, resulting from
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 7:624-632
Targeting Brutons tyrosine kinase (BTK) with a small molecule inhibitor may be useful in treatment of BTK-expressing malignancies because of the anti-apoptotic function of BTK in cancer cells. Furthermore, BTK inhibitors also exhibit anti-thrombotic
Publikováno v:
British Journal of Haematology. 136:574-589
Bruton's tyrosine kinase (BTK) was previously demonstrated to be a mediator of oxidative stress-induced apoptosis in irradiated neoplastic B-cells and B-cell precursors. Defective BTK expression in leukaemic B-cell precursors from infants with t(4;11
Autor:
Alexei O. Vassilev, Sanjive Qazi, Fatih M. Uckun, Chen Mao, Ilker Dibirdik, Alexey Benyumov, Hong Ma, Katayoon H. Emami
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:800-814
Molecular modeling studies led to the identification of LFM-A13 (alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl)propenamide) as a potent inhibitor of Polo-like kinase (Plk). LFM-A13 inhibited recombinant purified Plx1, the Xenopus homolog
Autor:
Darin D. DuMez, Heather E. Tibbles, Taracad K. Venkatachalam, Alexei O. Vassilev, Fatih M. Uckun
Publikováno v:
Current Drug Targets. 7:327-343
Multifunctional rational drug design of protein tyrosine kinases inhibitors allows a potent drug to be utilized to treat more than one disease for greater patient benefits. Many protein tyrosine kinases (PTK), including Janus kinase 3 (JAK3) and Brut
Autor:
C.L. Chen, A.S. Petkevich, Fatih M. Uckun, Alexei O. Vassilev, Taracad K. Venkatachalam, D. Erbeck
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:3279-3288
The pharmacokinetics, metabolism, and toxicity of Zidampidine, an aryl phosphate derivative of AZT, 3'-azidothymidine-5'-[p-bromophenyl methoxyalaninyl phosphate] were investigated in CD-1 mice. Following iv injection, Zidampidine was rapidly convert
Publikováno v:
European Journal of Haematology. 70:156-171
Fas (APO-1/CD95) is a 45-kDa membrane protein which regulates apoptosis in many lymphoid cell types. In the present study, FAS expression was examined in primary leukemic cells from infants with acute lymphoblastic leukemia (ALL). The cells were resi
Autor:
Michael A. Hupke, Fatih M. Uckun, Heather E. Tibbles, Alexei O. Vassilev, Christopher S. Navara
Publikováno v:
Biochemical and Biophysical Research Communications. 292:987-991
Ligation of thrombopoietin (TPO) to the platelet c-Mpl receptor induces numerous biochemical pathways in the absence of aggregation. Two forms of recombinant TPO are currently in clinical trials for the treatment of thrombocytopenia. This study focus