Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alexei M. Bygrave"'
Autor:
Jonathan P. Ling, Alexei M. Bygrave, Clayton P. Santiago, Rogger P. Carmen-Orozco, Vickie T. Trinh, Minzhong Yu, Yini Li, Ying Liu, Kyra D. Bowden, Leighton H. Duncan, Jeong Han, Kamil Taneja, Rochinelle Dongmo, Travis A. Babola, Patrick Parker, Lizhi Jiang, Patrick J. Leavey, Jennifer J. Smith, Rachel Vistein, Megan Y. Gimmen, Benjamin Dubner, Eric Helmenstine, Patric Teodorescu, Theodoros Karantanos, Gabriel Ghiaur, Patrick O. Kanold, Dwight Bergles, Ben Langmead, Shuying Sun, Kristina J. Nielsen, Neal Peachey, Mandeep S. Singh, W. Brian Dalton, Fatemeh Rajaii, Richard L. Huganir, Seth Blackshaw
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Precise and reliable gene delivery remains technically challenging. Here, the authors show that rationally designed frameshifting splicing can be used to express genes only in targeted cell types, with the potential to enhance the specificity AAV gen
Externí odkaz:
https://doaj.org/article/d3c897c79c354a7aba8f34a9159e9fad
Autor:
Alexei M. Bygrave, Ayesha Sengupta, Ella P. Jackert, Mehroz Ahmed, Beloved Adenuga, Erik Nelson, Hana L. Goldschmidt, Richard C. Johnson, Haining Zhong, Felix L. Yeh, Morgan Sheng, Richard L. Huganir
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112591- (2023)
Summary: Synapses in the brain exhibit cell-type-specific differences in basal synaptic transmission and plasticity. Here, we evaluated cell-type-specific specializations in the composition of glutamatergic synapses, identifying Btbd11 as an inhibito
Externí odkaz:
https://doaj.org/article/a451814dcee94a4a999a9f676a184c5b
Autor:
Casey N. Barber, Hana L. Goldschmidt, Brendan Lilley, Alexei M. Bygrave, Richard C. Johnson, Richard L. Huganir, Donald J. Zack, Daniel M. Raben
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 8, Pp 100247- (2022)
Phosphatidic acid is a key signaling molecule heavily implicated in exocytosis due to its protein-binding partners and propensity to induce negative membrane curvature. One phosphatidic acid-producing enzyme, phospholipase D (PLD), has also been impl
Externí odkaz:
https://doaj.org/article/ff4db0915c4049ca95f94efafaacc188
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-22 (2021)
Abstract Background Communication between brain areas has been implicated in a wide range of cognitive and emotive functions and is impaired in numerous mental disorders. In rodent models, various metrics have been used to quantify inter-regional neu
Externí odkaz:
https://doaj.org/article/22bf39cbab0a4110a2a090be5ddddd8f
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. However, the notion that abnormal dopamine creates psychotic symptoms by causing an aberrant assignment of salience that drives m
Externí odkaz:
https://doaj.org/article/9ef3ed9449964a9d809ff79da2fab625
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
Hypofunction of N-methyl-D-aspartate glutamate receptors (NMDARs), whether caused by endogenous factors like auto-antibodies or mutations, or by pharmacological or genetic manipulations, produces a wide variety of deficits which overlap with—but do
Externí odkaz:
https://doaj.org/article/9154faad51d240af972f598e0bfb0f0c
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2019)
Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cogni
Externí odkaz:
https://doaj.org/article/049e5537f0af46aa9199a3c34af969fc
Autor:
Richard C. Johnson, Han L. Tan, Alexei M. Bygrave, Qianwen Zhu, Richard L. Huganir, Adeline J. H. Yong
Publikováno v:
Proc Natl Acad Sci U S A
Hebbian plasticity, comprised of long-term potentiation (LTP) and depression (LTD), allows neurons to encode and respond to specific stimuli; while homeostatic synaptic scaling is a counterbalancing mechanism that enables the maintenance of stable ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026f38f15dee437b7d342702cdf621c9
https://doi.org/10.1073/pnas.1918436117
https://doi.org/10.1073/pnas.1918436117
Autor:
Casey N. Barber, Hana L. Goldschmidt, Brendan Lilley, Alexei M. Bygrave, Richard C. Johnson, Richard L. Huganir, Donald J. Zack, Daniel M. Raben
Publikováno v:
Journal of lipid research. 63(8)
Phosphatidic acid is a key signaling molecule heavily implicated in exocytosis due to its protein-binding partners and propensity to induce negative membrane curvature. One phosphatidic acid-producing enzyme, phospholipase D (PLD), has also been impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a23eac83b7c3c650e8ce6363425fc79
https://pubmed.ncbi.nlm.nih.gov/35764123
https://pubmed.ncbi.nlm.nih.gov/35764123
Autor:
Adenuga B, Richard C. Johnson, Jackert Ep, Ahmed M, Yeh Fl, Nelson E, Haining Zhong, Alexei M. Bygrave, Sheng M, Hana L. Goldschmidt, Sengupta A, Richard L. Huganir
SUMMARYSynapses in the brain exhibit cell-type-specific differences in basal synaptic transmission and plasticity. Here, we evaluated cell-type-specific differences in the composition of glutamatergic synapses, identifying Btbd11, as an inhibitory in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa9d7442d59ab167ed355570814c7392
https://doi.org/10.1101/2021.11.01.466782
https://doi.org/10.1101/2021.11.01.466782
