Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alexei M Bygrave"'
Autor:
Austin R Graves, Richard H Roth, Han L Tan, Qianwen Zhu, Alexei M Bygrave, Elena Lopez-Ortega, Ingie Hong, Alina C Spiegel, Richard C Johnson, Joshua T Vogelstein, Daniel J Tward, Michael I Miller, Richard L Huganir
Publikováno v:
eLife, Vol 10 (2021)
Elucidating how synaptic molecules such as AMPA receptors mediate neuronal communication and tracking their dynamic expression during behavior is crucial to understand cognition and disease, but current technological barriers preclude large-scale exp
Externí odkaz:
https://doaj.org/article/bbc936d28bba4fee99a9525f2f0b9c39
Publikováno v:
eLife, Vol 10 (2021)
The efficient knock-in of large DNA fragments to label endogenous proteins remains especially challenging in non-dividing cells such as neurons. We developed Targeted Knock-In with Two (TKIT) guides as a novel CRISPR/Cas9 based approach for efficient
Externí odkaz:
https://doaj.org/article/f28c7ab31bc7495cb8cd289fa0be3e67
Autor:
Alexei M. Bygrave, Ayesha Sengupta, Ella P. Jackert, Mehroz Ahmed, Beloved Adenuga, Erik Nelson, Hana L. Goldschmidt, Richard C. Johnson, Haining Zhong, Felix L. Yeh, Morgan Sheng, Richard L. Huganir
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112591- (2023)
Summary: Synapses in the brain exhibit cell-type-specific differences in basal synaptic transmission and plasticity. Here, we evaluated cell-type-specific specializations in the composition of glutamatergic synapses, identifying Btbd11 as an inhibito
Externí odkaz:
https://doaj.org/article/a451814dcee94a4a999a9f676a184c5b
Autor:
Casey N. Barber, Hana L. Goldschmidt, Brendan Lilley, Alexei M. Bygrave, Richard C. Johnson, Richard L. Huganir, Donald J. Zack, Daniel M. Raben
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 8, Pp 100247- (2022)
Phosphatidic acid is a key signaling molecule heavily implicated in exocytosis due to its protein-binding partners and propensity to induce negative membrane curvature. One phosphatidic acid-producing enzyme, phospholipase D (PLD), has also been impl
Externí odkaz:
https://doaj.org/article/ff4db0915c4049ca95f94efafaacc188
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-22 (2021)
Abstract Background Communication between brain areas has been implicated in a wide range of cognitive and emotive functions and is impaired in numerous mental disorders. In rodent models, various metrics have been used to quantify inter-regional neu
Externí odkaz:
https://doaj.org/article/22bf39cbab0a4110a2a090be5ddddd8f
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. However, the notion that abnormal dopamine creates psychotic symptoms by causing an aberrant assignment of salience that drives m
Externí odkaz:
https://doaj.org/article/9ef3ed9449964a9d809ff79da2fab625
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
Hypofunction of N-methyl-D-aspartate glutamate receptors (NMDARs), whether caused by endogenous factors like auto-antibodies or mutations, or by pharmacological or genetic manipulations, produces a wide variety of deficits which overlap with—but do
Externí odkaz:
https://doaj.org/article/9154faad51d240af972f598e0bfb0f0c
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2019)
Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cogni
Externí odkaz:
https://doaj.org/article/049e5537f0af46aa9199a3c34af969fc
Autor:
Jonathan P. Ling, Alexei M. Bygrave, Clayton P. Santiago, Rogger P. Carmen-Orozco, Vickie T. Trinh, Minzhong Yu, Yini Li, Ying Liu, Kyra D. Bowden, Leighton H. Duncan, Jeong Han, Kamil Taneja, Rochinelle Dongmo, Travis A. Babola, Patrick Parker, Lizhi Jiang, Patrick J. Leavey, Jennifer J. Smith, Rachel Vistein, Megan Y. Gimmen, Benjamin Dubner, Eric Helmenstine, Patric Teodorescu, Theodoros Karantanos, Gabriel Ghiaur, Patrick O. Kanold, Dwight Bergles, Ben Langmead, Shuying Sun, Kristina J. Nielsen, Neal Peachey, Mandeep S. Singh, W. Brian Dalton, Fatemeh Rajaii, Richard L. Huganir, Seth Blackshaw
Publikováno v:
Nature Communications. 13
Precise and reliable cell-specific gene delivery remains technically challenging. Here we report a splicing-based approach for controlling gene expression whereby separate translational reading frames are coupled to the inclusion or exclusion of muta
Autor:
Richard C. Johnson, Han L. Tan, Alexei M. Bygrave, Qianwen Zhu, Richard L. Huganir, Adeline J. H. Yong
Publikováno v:
Proc Natl Acad Sci U S A
Hebbian plasticity, comprised of long-term potentiation (LTP) and depression (LTD), allows neurons to encode and respond to specific stimuli; while homeostatic synaptic scaling is a counterbalancing mechanism that enables the maintenance of stable ne