Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Alexei Kurakin"'
Autor:
Alexei Kurakin, Dale E. Bredesen
Publikováno v:
Aging (Albany NY)
Ineffective results of clinical trials of over 200 anti-Alzheimer's drug candidates, with a 99.6% attrition rate, suggest that the current paradigm of Alzheimer's disease (AD) may be incomplete, necessitating exploration of alternative and complement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf916b810e82cd21d9d6cebc14e4a52
https://pubmed.ncbi.nlm.nih.gov/32957083
https://pubmed.ncbi.nlm.nih.gov/32957083
Autor:
Dale E. Bredesen, Alexei Kurakin
Publikováno v:
Oncotarget
// Alexei Kurakin 1 and Dale E. Bredesen 1,2 1 Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, University of California, Los Angeles, CA, USA 2 Buck Institute for Research on Aging, Novato, CA, USA Correspondence to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959aa74d4158e4b1012641c356fff49d
https://doi.org/10.18632/oncotarget.4221
https://doi.org/10.18632/oncotarget.4221
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e953 (2007)
Specific protein associations define the wiring of protein interaction networks and thus control the organization and functioning of the cell as a whole. Peptide recognition by PDZ and other protein interaction domains represents one of the best-stud
Externí odkaz:
https://doaj.org/article/2d201afe73934bb39f7405c56585b3e0
Autor:
Qiang Zhang, Cathy Vitelli, Andrzej Swistowski, Alexei Kurakin, Danielle Crippen, Mark Orcholski, Dale E. Bredesen
Publikováno v:
The Journal of Neuroscience. 29:15703-15712
Multiple recent reports implicate amyloid precursor protein (APP) signaling in the pathogenesis of Alzheimer's disease, but the APP-dependent signaling network involved has not been defined. Here, we report a novel consensus sequence for interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c1bc9a4c03e0e396f453d18ba42583
https://doi.org/10.1523/jneurosci.4351-09.2009
https://doi.org/10.1523/jneurosci.4351-09.2009
Autor:
Dale E. Bredesen, Alexei Kurakin
Publikováno v:
Journal of Molecular Recognition. 20:39-50
Target-assisted iterative screening (TAIS) has been applied to a random phage-displayed peptide library in a search for novel ligands of the third baculovirus IAP ('inhibitors of apoptosis') repeat (BIR) domain of cIAP1. The peptides selected in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b76f59448a4656ab6ec1b37e269c75
https://doi.org/10.1002/jmr.809
https://doi.org/10.1002/jmr.809
Publikováno v:
Annals of the New York Academy of Sciences. 926:52-63
One of the major goals of researchers in the field of apoptosis is to understand the molecular mechanisms of the various components of the apoptotic pathways, with the hope to identify targets for novel cancer therapies. The discovery of a TNF-relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffacfd6a3c87f8c61e44545bef3ac581
https://doi.org/10.1111/j.1749-6632.2000.tb05598.x
https://doi.org/10.1111/j.1749-6632.2000.tb05598.x
Publikováno v:
Proceedings of the National Academy of Sciences. 102:5838-5843
Infected cell protein 0 (ICP0) is a 775-residue multifunctional herpes simplex virus protein associated with numerous functions related to transactivation of gene expression and repression of host defenses to infection. We report that an uncharted do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1580f2c5d7dbce5417c8f6a12c4220
https://doi.org/10.1073/pnas.0501253102
https://doi.org/10.1073/pnas.0501253102
Autor:
Alexei Kurakin
Publikováno v:
Biological Chemistry. 386:247-254
The cell, as a molecular system, is often interpreted in terms of complex clockworks, and the design charts of mechanical and electrical engineering are assumed to provide adequate approximations for the description of cellular organization. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f261a05750c82ec2c36c70ef92709fe8
https://doi.org/10.1515/bc.2005.030
https://doi.org/10.1515/bc.2005.030
Autor:
Alexei, Kurakin
Publikováno v:
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life). 57:59-63
Accumulating experimental evidence of stochasticity, self-organization and abrupt non-linear transitions underlying the dynamics of cellular structure and function is increasingly more consistent with the concepts and models of phase transitions, cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4418d52f98d3c2c8ec9d36af8e58847
https://doi.org/10.1080/15216540400024314
https://doi.org/10.1080/15216540400024314
Autor:
Brian K. Kay, Mehrdad Mohseni, Karon Abe, Keli Song, Nordine Benhaga, Ferry Sandra, Alexei Kurakin, Roya Khosravi-Far, Tai-Guang Jin
Publikováno v:
Journal of Biological Chemistry. 279:55594-55601
Here we show a novel mechanism by which FLICE-like inhibitory protein (c-FLIP) regulates apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and one of its receptors, DR5. c-FLIP is a critical regulator of the T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72107853fe4ac311ee71f46a787e3d9
https://doi.org/10.1074/jbc.m401056200
https://doi.org/10.1074/jbc.m401056200