Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alexei Gorelik"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insig
Externí odkaz:
https://doaj.org/article/64fac15bbf80415292cee1c052351f44
Publikováno v:
Science Advances. 9
Sialic acids linked to glycoproteins and glycolipids are important mediators of cell and protein recognition events. These sugar residues are removed by neuraminidases (sialidases). Neuraminidase-1 (sialidase-1 or NEU1) is a ubiquitously expressed ma
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(33)
The mannose-6-phosphate (M6P) pathway is responsible for the transport of hydrolytic enzymes to lysosomes. N-acetylglucosamine-1-phosphotransferase (GNPT) catalyzes the first step of tagging these hydrolases with M6P, which when recognized by recepto
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Mutations in acid sphingomyelinase result in toxic accumulation of sphingomyelin and cause Niemann-Pick disease. Here, the authors report structures of mammalian acid sphingomyelinase, which reveal details of the molecular mechanism of acid sphingomy
Externí odkaz:
https://doaj.org/article/64dbae6e66f941cbb1af708261839ee8
Publikováno v:
Science Advances
The 3D structure of the complex formed by the enzymes GLB1 and CTSA furthers our understanding of lysosomal storage diseases.
The enzymes β-galactosidase (GLB1) and neuraminidase 1 (NEU1; sialidase 1) participate in the degradation of glycoprot
The enzymes β-galactosidase (GLB1) and neuraminidase 1 (NEU1; sialidase 1) participate in the degradation of glycoprot
Publikováno v:
Protein Sci
The ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) are a family of enzymes found on the cell surface and in the lumen of certain organelles, that are major regulators of purinergic signaling. Their intracellular roles, however, have not
Publikováno v:
The FEBS Journal. 285:2481-2494
The ecto-nucleotide pyrophosphatase/phosphodiesterase (NPP) enzyme family modulates purinergic signaling by degrading extracellular nucleotides. CD203c (NPP3, ENPP3) regulates the inflammatory response of basophils via ATP hydrolysis and is a marker
Publikováno v:
Journal of Biological Chemistry. 292:7087-7094
Absorption of dietary sphingomyelin (SM) requires its initial degradation into ceramide, a process catalyzed by the intestinal enzyme alkaline sphingomyelinase (alk-SMase, NPP7, ENPP7). alk-SMase belongs to the nucleotide pyrophosphatase/phosphodiest
Autor:
Bhushan Nagar, Ludovic J. Deny, Alexandre Beautrait, Anne Marinier, Agne Tubeleviciute-Aydin, Jeffrey Lynham, Naoto Soya, Alexei Gorelik, Gergely L. Lukacs, Andréa C. LeBlanc, Gyanesh Sharma
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Caspase-6 is a cysteine protease that plays essential roles in programmed cell death, axonal degeneration, and development. The excess neuronal activity of Caspase-6 is associated with Alzheimer disease neuropathology and age-dependent cognitive impa
Autor:
Michael Gelsomino, Katalin Illes, Ha Nguyen, Alexey Dementiev, Bhushan Nagar, Alexei Gorelik, Saman Shabani, Eun-Young Erin Ahn, Ninh Doan, Andrzej Joachimiak
Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the development of new therapeutics against melanoma and glioblastoma tumors. Despite the strong interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818fea44b03ffba7c4fc78a023ba016a
https://europepmc.org/articles/PMC6863082/
https://europepmc.org/articles/PMC6863082/