Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alexei Belenky"'
Autor:
Clifford G. Phaneuf, Konstantin Aizikov, Dmitry Grinfeld, Arne Kreutzmann, Daniel Mourad, Oliver Lange, Daniel Dai, Bailin Zhang, Alexei Belenky, Alexander A. Makarov, Alexander R. Ivanov
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Mass spectrometry-based thermal stability assays (MS-TSA) are a promising approach to characterize protein-ligand interaction, and several strategies have been recently developed to improve their performance. Here, the authors combine three recent st
Externí odkaz:
https://doaj.org/article/05496a164ec94f12bd49c4bcf4419555
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The microbiome is essential for host health, and perturbations resulting from antibiotic use can lead to dysbiosis and disease. Diet can be a powerful modulator of microbiome composition and function, with the potential to mitigate the negative effec
Externí odkaz:
https://doaj.org/article/ed1cdbbdf31c40e78bcc3bdae10400e4
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Frontiers in Microbiology
Frontiers in Microbiology
The microbiome is essential for host health, and perturbations resulting from antibiotic use can lead to dysbiosis and disease. Diet can be a powerful modulator of microbiome composition and function, with the potential to mitigate the negative effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369b777081d344ab5a2591b472ace2dd
https://www.frontiersin.org/articles/10.3389/fmicb.2021.637282/full
https://www.frontiersin.org/articles/10.3389/fmicb.2021.637282/full
Autor:
Alexei Belenky, Felix Chapovsky, Marc Duey, Michael Frid, Maria Vilenchik, Alexandra Kuznetsova
Publikováno v:
Cancer Research. 80:5161-5161
Thermal shift assay was utilized to demonstrate target engagement of drug candidate compounds to their specific targets. We explored novel cancer dormancy targets: DYRK1B and AXL kinases and assessed interaction with corresponding small molecule inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7fc17930aa02db099dae4cee1822ee8
https://doi.org/10.1158/1538-7445.am2020-5161
https://doi.org/10.1158/1538-7445.am2020-5161
Publikováno v:
Current Protocols in Nucleic Acid Chemistry
Owing to the markedly increased reactivity of amino functional groups versus hydroxyls, the 5'-amino-5'-deoxy nucleoside and nucleotide analogs have proven widely useful in biological, pharmaceutical and genomic applications. However, synthetic proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75762ccfeab0f11c9909baafae7fc938
https://doi.org/10.1093/nar/gkf502
https://doi.org/10.1093/nar/gkf502
Publikováno v:
Analytical Biochemistry. 280:182-185
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52848916f02d4aedf9aab5bb52e306e3
https://doi.org/10.1006/abio.2000.4507
https://doi.org/10.1006/abio.2000.4507
Publikováno v:
Antisense and Nucleic Acid Drug Development. 8:35-42
For the enzymatic digestion of a 25-mer phosphorothioate (PS) oligonucleotide, the reaction kinetics was previously determined to be the sum of two parallel processes: a fast and a very slow phase of digestion suggesting a two-exponential model. A ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aafa1e34f3bd9b6f12b8da01eecbcc7
https://doi.org/10.1089/oli.1.1998.8.35
https://doi.org/10.1089/oli.1.1998.8.35
Publikováno v:
International Journal of Mass Spectrometry and Ion Processes. :331-350
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS) was used to sequence modified oligonucelotides (MONs). Under delayed pulsed ion extraction conditions, sequence ions of MONs resulting from fragmentation withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e473da18bd06ac38cf450e535bbf9957
https://doi.org/10.1016/s0168-1176(97)00232-2
https://doi.org/10.1016/s0168-1176(97)00232-2
Publikováno v:
Nucleic Acids Research. 25:4219-4223
The progress of antisense DNA therapy demands development of reliable and convenient methods for sequencing short single-stranded oligonucleotides. A method of phosphorothioate antisense DNA sequencing analysis using UV detection coupled to capillary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2965c105e3e2b40b3c73ee971cd7f0b0
https://doi.org/10.1093/nar/25.21.4219
https://doi.org/10.1093/nar/25.21.4219
Publikováno v:
Nucleic Acids Research. 25:3615-3620
The in vitro stability and metabolism of GEM[91, a 25mer phosphorothioate antisense oligonucleotide complementary to the gag mRNA region of HIV-1, was investigated using capillary electrophoresis (CE). The in vitro degradation of the parent compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2e16b428dd4f71a02c0db3114ca472
https://doi.org/10.1093/nar/25.18.3615
https://doi.org/10.1093/nar/25.18.3615