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pro vyhledávání: '"Alexei Bakhirev"'
Autor:
Sunil Kher, Alexei Bakhirev, Madhavi Pannala, Naoki Sakurai, Norma Wilson, Frank Gorcsan, Ila Sircar, Guang Yang, Shao-Hui Zhang, Jie-Fei Cheng, John A. Gaudette, Miguel Barbosa, Phoebe Yuen
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
Synthesis and structure–activity relationship of a series of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitrile derivatives as EGFR inhibitors is described. Compounds 29 and 30 showed potent in vitro inhibitory activity in the enzymatic assay as