Výsledky vyhledávání - "Alexei A. Koshkin"

Conformationally restricted triplex-forming oligonucleotides (TFOs). Binding properties of α-l-LNA and introduction of the N7-glycosylated LNA-guanosine

Autor: Alexei A. Koshkin

Publikováno v: Tetrahedron. 62:5962-5972

The method for scaled-up production of α- l -LNA phosphoramidite building blocks containing thymine and 5-methylcytosine nucleobases is described. Binding properties of pyrimidine TFOs modified with α- l -LNA are reported. In contrast to LNA TFOs,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6a20a0a6f67d16c15589dde0c0c7386
https://doi.org/10.1016/j.tet.2006.04.016

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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

Autor: Liam Good, Tomas Hökfelt, Henrik Oerum, Alexei A. Koshkin, Frank Porreca, Jesper Wengel, Kunkun Ren, Thomas Johnsson, Michael H. Ossipov, Nana Jakobsen, Josephine Lai, Claes Wahlestedt, Johanna Kela, Christian Broberger, Mogens Havsteen Jacobsen, Peter Salmi, Jan Skouv

Publikováno v: Proceedings of the National Academy of Sciences. 97:5633-5638

Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a high-affinity DNA analog, locked nucleic acid (LNA), confers several desired properties to antisense agents. Unlike DNA,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4511065dba6b23b143c097540b5c1040
https://doi.org/10.1073/pnas.97.10.5633

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The conformations of locked nucleic acids (LNA)

Autor: Michael B. Petersen, Alexei A. Koshkin, Sanjay K. Singh, Katrine E. Nielsen, Britta M. Dahl, Kent Bondensgaard, Jens Peter Jacobsen, Christina B. Nielsen, Jesper Wengel, Gitte A. Jensen, Vivek K. Rajwanshi

Publikováno v: Journal of Molecular Recognition. 13:44-53

We have used 2D NMR spectroscopy to study the sugar conformations of oligonucleotides containing a conformationally restricted nucleotide (LNA) with a 2'-O, 4'-C-methylene bridge. We have investigated a modified 9-mer single stranded oligonucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e9521b8e2b6c26ddef508af2613cbad
https://doi.org/10.1002/(sici)1099-1352(200001/02)13:1<44::aid-jmr486>3.0.co

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Evaluation of Oligonucleotides Containing Two Novel 2′-O-Methyl Modified Nucleotide Monomers: A 3′-C-Allyl and a 2′-O-3′-C-Linked Bicyclic Derivative

Autor: Alexei A. Koshkin, Carl Erik Olsen, Henrik M. Pfundheller, Jesper Wengel

Publikováno v: Nucleosides and Nucleotides. 18:2017-2030

The two ribo-configured nucleosides 1-(3-C-allyl-2-O-methyl-beta-D-ribo-pentofuranosyl)thymine 3 and (1S,5R,6R,8R)-5-hydroxy-6-(hydroxymethyl)-1-methoxy-8-(thymin-1-yl )- 2,7-dioxabicyclo[3.3.0]octane 6 have been transformed into their corresponding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a45e127e03de6d231149a15b0041155
https://doi.org/10.1080/07328319908044861

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Novel convenient syntheses of LNA [2.2.1]bicyclo nucleosides

Autor: Jesper Wengel, Alexei A. Koshkin, Vivek K. Rajwanshi

Publikováno v: Tetrahedron Letters. 39:4381-4384

LNA (Locked Nucleic Acids) is a novel oligonucleotide analogue containing [2.2.1]bicyclo nucleoside monomers. A novel and significantly improved method for convergent synthesis of LNA [2.2.1]bicyclo nucleosides using a 4-C-tosyloxymethyl-1, 2-di-O-ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5b782808783d6a04217409925cf092f
https://doi.org/10.1016/s0040-4039(98)00706-0

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LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Autor: Ravindra Kumar, Poul Nielsen, Carl Erik Olsen, Michael Meldgaard, Vivek K. Rajwanshi, Alexei A. Koshkin, Jesper Wengel, Sanjay K. Singh

Publikováno v: Koshkin, A A, Singh, S K, Nielsen, P, Rajwanshi, V K, Kumar, R, Meldgaard, M, Olsen, C E & Wengel, J 1998, ' LNA (Locked Nucleic Acids): Synthesis of Adenin, Cytosine, Guanine, 5-Methylcytosine, Thymine and Uracil Bicyclonucleoside Monomers, Oligomerisation, and Unprecedented Nucleic Acid Recognition ', Tetrahedron, vol. 54, no. 14, pp. 3607-3630 . https://doi.org/10.1016/S0040-4020(98)00094-5

LNA (Locked Nucleic Acids), consisting of 2′- O ,4′- C -methylene bicyclonucleoside monomers, is efficiently synthesized and its nucleic acid recognition potential evaluated for six different nucleobases, namely adenine, cytosine, guanine, 5-meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04801f81c70b76e3a877f0bc6779ca63
https://doi.org/10.1016/s0040-4020(98)00094-5

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