Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Alexei A. Grom"'
Autor:
Alexei A. Grom, Scott W. Canna, Rolla F. Abu-Arja, Rashmi Sinha, Luciana Peixoto, Elvira Cannizzaro, Shanmuganathan Chandrakasan, Kyla Driest, Rebecca Marsh, Bénédicte Neven, Karen Onel, Sampath Prahalad, Susan Prockop, Pierre Quartier, Johannes Roth, Grant Schulert, Juliana M.F. Silva, Donna Wall, Ulrike Zeilhofer
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-13 (2024)
Abstract It has been increasingly recognized that there is a subset of patients with refractory systemic JIA, who have failed all available medications and may benefit from HSCT. The increasing experience with HSCT in SJIA, suggests that despite the
Externí odkaz:
https://doaj.org/article/f82d150206794485be3d6684b703536d
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-5 (2024)
Abstract Although the introduction of the IL-1 and IL-6 inhibiting biologics in 2012 has revolutionized the treatment and markedly improved outcomes for many patients with SJIA, about 20% of these patients continue to have active disease, have marked
Externí odkaz:
https://doaj.org/article/d5ef467d5ddc43e1a600f84c6143d7b8
Autor:
Rashmi Sinha, Fabrizio De Benedetti, Alexei A. Grom, on behalf of the participants listed below
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/f6fcee9e7a5743ddb56279b2265e501a
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss S1, Pp 1-4 (2024)
Abstract The substantial morbidity and mortality associated with refractory systemic JIA underlies the need for new treatment approaches. However, progress in this area has been limited by the difficulty of enrolling these patients in clinical trials
Externí odkaz:
https://doaj.org/article/a701bfd93a34490baa23aa947625826b
Autor:
Emely L. Verweyen, Kairavee Thakkar, Sanjeev Dhakal, Elizabeth Baker, Kashish Chetal, Daniel Schnell, Scott Canna, Alexei A. Grom, Nathan Salomonis, Grant S. Schulert
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 22 (2023)
Systemic autoimmune and autoinflammatory diseases are characterized by genetic and cellular heterogeneity. While current single-cell genomics methods provide insights into known disease subtypes, these analysis methods do not readily reveal novel cel
Externí odkaz:
https://doaj.org/article/d5179c6c7e644a40aec238db94ea243c
Autor:
Peter Hur, Kathleen G. Lomax, Raluca Ionescu-Ittu, Ameur M. Manceur, Jipan Xie, Jordan Cammarota, Raju Gautam, Navneet Sanghera, Nina Kim, Alexei A. Grom
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Although canakinumab has demonstrated efficacy in multiple trials in patients with periodic fever syndromes (PFS), the evidence on initiation of canakinumab among PFS patients in real world setting is not well understood. We aimed
Externí odkaz:
https://doaj.org/article/895a29c829b840f387ab20d693d70cfe
Autor:
Najla Aljaberi, Elena Tronconi, Grant Schulert, Alexei A. Grom, Daniel J. Lovell, Jennifer L. Huggins, Michael Henrickson, Hermine I. Brunner
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 18, Iss 1, Pp 1-6 (2020)
Abstract Background Serum phagocyte-derived alarmins S100A8/9 and S100A12 are considered useful for the assessment of inflammatory diseases. Our study evaluated the use of S100 proteins in a pediatric clinical setting for estimating disease activity
Externí odkaz:
https://doaj.org/article/64aab2d1a7854ac6b6bca21c0423981f
Autor:
Denny K. Gao, Nathan Salomonis, Maggie Henderlight, Christopher Woods, Kairavee Thakkar, Alexei A. Grom, Sherry Thornton, Michael B. Jordan, Kathryn A. Wikenheiser-Brokamp, Grant S. Schulert
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Macrophage activation syndrome (MAS) is a life-threatening cytokine storm complicating systemic juvenile idiopathic arthritis (SJIA) driven by IFN-γ. SJIA and MAS are also associated with an unexplained emerging inflammatory lung disease (SJIA-LD),
Externí odkaz:
https://doaj.org/article/47d1d93c929347e5ab460781fc2d3411
Autor:
Jessica L. Turnier, Ndate Fall, Sherry Thornton, David Witte, Michael R. Bennett, Simone Appenzeller, Marisa S. Klein-Gitelman, Alexei A. Grom, Hermine I. Brunner
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-11 (2017)
Abstract Background Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both serum and urine as potent
Externí odkaz:
https://doaj.org/article/f30f67eed9284777beeaa2f31678ec99
Autor:
Rachel A. Brown, Maggie Henderlight, Thuy Do, Shima Yasin, Alexei A. Grom, Monica DeLay, Sherry Thornton, Grant S. Schulert
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background: Systemic juvenile idiopathic arthritis (SJIA) is a chronic childhood arthropathy with features of autoinflammation. Early inflammatory SJIA is associated with expansion and activation of neutrophils with a sepsis-like phenotype, but neutr
Externí odkaz:
https://doaj.org/article/5b997ef3f05f46a8b581b4d6fb403c98