Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Alexei, Medvedev"'
Autor:
Olga Buneeva, Alexei Medvedev
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1303 (2024)
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), also known as Parkinson’s disease protein 5, is a highly expressed protein in the brain. It plays an important role in the ubiquitin–proteasome system (UPS), where it acts as a deubiquitinase (DUB
Externí odkaz:
https://doaj.org/article/ce79d6930e054131bfa0b777ae105ad2
Autor:
Olga Buneeva, Arthur Kopylov, Oksana Gnedenko, Marina Medvedeva, Alexander Veselovsky, Alexis Ivanov, Victor Zgoda, Alexei Medvedev
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7634 (2023)
Affinity-based proteomic profiling is widely used for the identification of proteins involved in the formation of various interactomes. Since protein–protein interactions (PPIs) reflect the role of particular proteins in the cell, identification of
Externí odkaz:
https://doaj.org/article/8c89fb40b396425f917593a71641902c
Autor:
Alexei Medvedev, Olga Buneeva
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Isatin (indole-2,3-dione) is an endogenous regulator, exhibiting various behavioral, biological, and pharmacological activities. Synthesis of isatin includes several crucial stages: cleavage of the tryptophan side chain and subsequent oxidation of th
Externí odkaz:
https://doaj.org/article/2573dd60ad4d464b8121c2126370a23d
Publikováno v:
Data in Brief, Vol 38, Iss , Pp 107276- (2021)
Fractions of 26S and 20S proteasomes isolated from the rabbit brain by the method of salt fractionation (salt-induced precipitation) contain intrinsic proteasome proteins responsible for assembly of the core particle and regulatory particle of protea
Externí odkaz:
https://doaj.org/article/caf8c71a07a241bba1b6a2628cce34ee
Autor:
Marina Solovieva, Yuri Shatalin, Irina Odinokova, Olga Krestinina, Yulia Baburina, Yana Lomovskaya, Anton Pankratov, Natalia Pankratova, Olga Buneeva, Arthur Kopylov, Alexei Medvedev, Vladimir Akatov
Publikováno v:
Membranes, Vol 12, Iss 9, p 845 (2022)
Disulfiram (DSF) and its derivatives were here investigated as antineoplastic agents, and their important feature is the ability to influence the UPS. We have recently shown that hydroxocobalamin catalyzes the aerobic oxidation of diethyldithiocarbam
Externí odkaz:
https://doaj.org/article/9ee1b52052b143af92f3503c44d85a7d
Autor:
Olga Buneeva, Alexei Medvedev
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3705 (2022)
Ubiquitination (the covalent attachment of ubiquitin molecules to target proteins) is one of the main post-translational modifications of proteins. Historically, the type of polyubiquitination, which involves K48 lysine residues of the monomeric ubiq
Externí odkaz:
https://doaj.org/article/e0a62ec5734e4373881dde077f42a7cb
Autor:
Konstantin Virnik, Margherita Rosati, Alexei Medvedev, Aaron Scanlan, Gabrielle Walsh, Frances Dayton, Kate E Broderick, Mark Lewis, Yvonne Bryson, Jeffrey D Lifson, Ruth M Ruprecht, Barbara K Felber, Ira Berkower
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0228163 (2020)
Anti-retroviral therapy (ART) has been highly successful in controlling HIV replication, reducing viral burden, and preventing both progression to AIDS and viral transmission. Yet, ART alone cannot cure the infection. Even after years of successful t
Externí odkaz:
https://doaj.org/article/a5d64ab2c3e94bdd92d5f3a09c3ae780
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 591 (2020)
Mitochondria, the energy stations of the cell, are the only extranuclear organelles, containing their own (mitochondrial) DNA (mtDNA) and the protein synthesizing machinery. The location of mtDNA in close proximity to the oxidative phosphorylation sy
Externí odkaz:
https://doaj.org/article/a0eddd1c69424fe7816c04093e6e705f
Autor:
Valerii Fedchenko, Arthur Kopylov, Nadezhda Kozlova, Olga Buneeva, Alexei Kaloshin, Victor Zgoda, Alexei Medvedev
Publikováno v:
Kidney & Blood Pressure Research, Vol 41, Iss 5, Pp 593-603 (2016)
Background/Aims: Renalase is a recently discovered flavoprotein involved in regulation of blood pressure. Altered renalase levels have been found in blood of patients with end stage renal disease. The antihypertensive effect of circulating renalase i
Externí odkaz:
https://doaj.org/article/dc35edf7b0be454e9855a808d1afb7df
Autor:
Gabrielle Walsh, Wenshuo Zhou, Alexei Medvedev, Barbara K. Felber, Sanjai Kumar, Jasper Perry-Anderson, Victoria Majam, Konstantin Virnik, Ira Berkower
Publikováno v:
Biochem Biophys Res Commun
There is an urgent need for a malaria vaccine that can prevent severe disease in young children and adults. Despite earlier work showing an immunological mechanism for preventing infection and reducing disease severity, there is currently no reliable