Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alexandru-Emil Matei"'
Autor:
Yi-Nan Li, Chih-Wei Chen, Thuong Trinh-Minh, Honglin Zhu, Alexandru-Emil Matei, Andrea-Hermina Györfi, Frederic Kuwert, Philipp Hubel, Xiao Ding, Cuong Tran Manh, Xiaohan Xu, Christoph Liebel, Vladyslav Fedorchenko, Ruifang Liang, Kaiyue Huang, Jens Pfannstiel, Min-Chuan Huang, Neng-Yu Lin, Andreas Ramming, Georg Schett, Jörg H. W. Distler
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation. In inflammatory arthritis such as rheumatoid arthritis (RA), however, increased osteoclast differentiation and activit
Externí odkaz:
https://doaj.org/article/9ac47eda1306433987ca42044a6cf8fb
Autor:
Ariella Zehender, Jingang Huang, Andrea-Hermina Györfi, Alexandru-Emil Matei, Thuong Trinh-Minh, Xiaohan Xu, Yi-Nan Li, Chih-Wei Chen, Jianping Lin, Clara Dees, Christian Beyer, Kolja Gelse, Zhong-Yin Zhang, Christina Bergmann, Andreas Ramming, Walter Birchmeier, Oliver Distler, Georg Schett, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Hyperactivation of TGFβ signaling is a common feature of fibrotic diseases. Here the authors show that genetic or pharmacologic inactivation of the tyrosine phosphatase SHP2 prevents TGFβ-induced JAK2/STAT3 signaling, inhibits fibroblast activation
Externí odkaz:
https://doaj.org/article/ca9d656a05724b31bfb9bc55df9634bf
Autor:
Alexandru‐Emil Matei, Markéta Kubánková, Liyan Xu, Andrea‐Hermina Györfi, Evgenia Boxberger, Despina Soteriou, Maria Papava, Julia Prater, Xuezhi Hong, Christina Bergmann, Martin Kräter, Georg Schett, Jochen Guck, Jörg H. W. Distler
Publikováno v:
Arthritis & Rheumatology
ObjectivePathologically activated circulating immune cells, including monocytes, play major roles in systemic sclerosis (SSc). Their functional characterization can provide crucial information with direct clinical relevance. However, tools for the ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e611733706f82a5e0bd08e5372f3096f
https://hdl.handle.net/21.11116/0000-000C-CDAE-A21.11116/0000-000D-0A87-0
https://hdl.handle.net/21.11116/0000-000C-CDAE-A21.11116/0000-000D-0A87-0
Autor:
Xiang Zhou, Thuong Trinh‐Minh, Alexandru‐Emil Matei, Andrea‐Hermina Györfi, Xuezhi Hong, Christina Bergmann, Georg Schett, John Atkinson, Rowann Bowcutt, Jessal Patel, Timothy S. Johnson, Jörg H.W. Distler
Publikováno v:
Arthritis & Rheumatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14ae7fb94aac1c96804e554ca1c5ba78
https://doi.org/10.1002/art.42518
https://doi.org/10.1002/art.42518
Autor:
Despina Soteriou, Markéta Kubánková, Christine Schweitzer, Rocío López-Posadas, Rashmita Pradhan, Oana-Maria Thoma, Andrea-Hermina Györfi, Alexandru-Emil Matei, Maximilian Waldner, Jörg H. W. Distler, Stefan Scheuermann, Jens Langejürgen, Markus Eckstein, Regine Schneider-Stock, Raja Atreya, Markus F. Neurath, Arndt Hartmann, Jochen Guck
Publikováno v:
nature biomedical engineering
During surgery, rapid and accurate histopathological diagnosis is essential for clinical decision making. Yet the prevalent method of intra-operative consultation pathology is intensive in time, labour and costs, and requires the expertise of trained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760e0d54fbfa22e893d53d8f7e1d18c6
https://hdl.handle.net/21.11116/0000-000C-F245-521.11116/0000-0009-9484-A
https://hdl.handle.net/21.11116/0000-000C-F245-521.11116/0000-0009-9484-A
Autor:
Alexandru-Emil, Matei, Markéta, Kubánková, Liyan, Xu, Andrea-Hermina, Györfi, Evgenia, Boxberger, Despina, Soteriou, Maria, Papava, Julia, Prater, Xuezhi, Hong, Christina, Bergmann, Martin, Kräter, Georg, Schett, Jochen, Guck, Jörg H W, Distler
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.).
Pathologically activated circulating immune cells, including monocytes, play major roles in systemic sclerosis (SSc). Their functional characterization can provide crucial information with direct clinical relevance. However, tools for evaluation of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85a9179238cff1a7e213d9e3718871a7
https://pubmed.ncbi.nlm.nih.gov/36281753
https://pubmed.ncbi.nlm.nih.gov/36281753
Autor:
Julia Winkler, Andreas Mackensen, Jörg H W Distler, Clara Dees, Xianyi Meng, Andreas Beilhack, Wolfgang Herr, Honglin Zhu, Cuong Tran-Manh, Thuong Trinh-Minh, Katja Dreißigacker, Mirjana Ziemer, Yun Zhang, Bernd M. Spriewald, Chih-Wei Chen, Alexandru-Emil Matei, Sigrid Karrer, Daniel Wolff, Georg Schett, Lichong Shen, Markus Ditschkowski, Stefan Krauss
Publikováno v:
Blood. 137:2403-2416
Chronic graft-versus-host disease (cGVHD) is a major life-threatening complication of allogeneic hematopoietic stem cell transplantation. The molecular mechanisms underlying cGVHD remain poorly understood, and targeted therapies for clinical use are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a60a1e95fd9c059d23e4af1f24e9b75
https://doi.org/10.1182/blood.2020008720
https://doi.org/10.1182/blood.2020008720
Autor:
Philipp Ritt, Christoph Treutlein, Christina Bergmann, Andreas Ramming, Markus Köhner, Olaf Prante, Tobias Bäuerle, Alina Soare, Torsten Kuwert, Clara Dees, Jörg H W Distler, Michael Cordes, Theresa Ida Götz, Anna-Theresa Müller, Armin Atzinger, Verena Schönau, Oliver Distler, Christian Schmidkonz, Koray Tascilar, Johannes Knitza, Andrea-Hermina Györfi, Georg Schett, Anja Lück, Alexandru-Emil Matei
Publikováno v:
The Lancet Rheumatology. 3:e185-e194
Summary Background Interstitial lung disease (ILD) is the most common cause of death in systemic sclerosis. To date, the progression of systemic sclerosis-associated ILD is judged by the accrual of lung damage on CT and pulmonary function tests. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28e361d61a3ec6ad12acd7889f6b6801
https://doi.org/10.1016/s2665-9913(20)30421-5
https://doi.org/10.1016/s2665-9913(20)30421-5
Autor:
Arndt Hartmann, Markus F. Neurath, Raja Atreya, Maximilian J. Waldner, Oana-Maria Thoma, Despina Soteriou, Rashmita Pradhan, Markéta Kubánková, Regine Schneider-Stock, Jens Langejürgen, Andrea-Hermina Györfi, Jochen Guck, Rocío López-Posadas, Christine Schweitzer, Stefan Scheuermann, Jörg H W Distler, Alexandru-Emil Matei
Rapid and accurate histopathological diagnosis during surgery is critical for clinical decision-making. The prevalent method of intraoperative consultation pathology is time, labour and cost intensive and requires the expertise of trained pathologist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b75596b07326322803d3899bca420e07
https://doi.org/10.1101/2021.11.30.21267075
https://doi.org/10.1101/2021.11.30.21267075
Autor:
Michael Stürzl, Christian Beyer, Christiane Maier, Simon Rauber, Andreas Ramming, Falk Butter, Astrid Jüngel, Arif B. Ekici, Jörg H W Distler, Clara Dees, Steffen Uebe, Christoph Daniel, Stephen L. Nutt, Stefanie Weber, Michael Sticherling, Hans P. Kiener, Kolja Gelse, Georg Schett, Emmanuel Karouzakis, Susetta Finotto, E. Pachera, David W. Boykin, Alexandru-Emil Matei, Mark H. Kaplan, Andreas E. Kremer, Alina Soare, Elisabeth Naschberger, Oliver Distler, Gregory M.K. Poon, Markus Luber, Chih-Wei Chen, Alexander Kreuter, Thomas Wohlfahrt
Publikováno v:
Nature
Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3525228a2dbf2fe6b17117fd7441a0
https://doi.org/10.1038/s41586-019-0896-x
https://doi.org/10.1038/s41586-019-0896-x