Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alexandru Chelu"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The sinus node (SN) serves as the primary pacemaker of the heart and is the first component of the cardiac conduction system. Due to its anatomical properties and sample scarcity, the cellular composition of the human SN has been historicall
Externí odkaz:
https://doaj.org/article/ef26873119ee44129891b57221771124
Autor:
Alexandra Njegić, Lina Laid, Min Zi, Eleni Maniati, Jun Wang, Alexandru Chelu, Laura Wisniewski, Jenna Hunter, Sukhpal Prehar, Nicholas Stafford, Chaim Gilon, Amnon Hoffman, Michael Weinmüller, Horst Kessler, Elizabeth J. Cartwright, Kairbaan Hodivala-Dilke
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100069- (2024)
Heart failure remains one of the largest clinical burdens globally, with little to no improvement in the development of disease-eradicating therapeutics. Integrin targeting has been used in the treatment of ocular disease and cancer, but little is kn
Externí odkaz:
https://doaj.org/article/a3900e0a7f874b28bce6fe50725d27f9
Autor:
Claire Wilson, Nicholas Stafford, Min Zi, Alexandru Chelu, Barbara C. Niort, Yatong Li, Florence Baudoin, Sukhpal Prehar, Andrew W. Trafford, Elizabeth J. Cartwright
Publikováno v:
Journal of Molecular and Cellular Cardiology. 172:41-51
Plasma membrane calcium ATPase 1 (PMCA1, Atp2b1) is emerging as a key contributor to cardiac physiology, involved in calcium handling and myocardial signalling. In addition, genome wide association studies have associated PMCA1 in several areas of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca367321e1480a1e7f420eea409c924
https://doi.org/10.1016/j.yjmcc.2022.07.011
https://doi.org/10.1016/j.yjmcc.2022.07.011
Publikováno v:
Chelu, A, Williams, S, Keavney, B D & Talavera, D 2022, ' Joint analysis of functionally related genes yields further candidates associated with Tetralogy of Fallot ', Journal of Human Genetics . https://doi.org/10.1038/s10038-022-01051-y
Although several genes involved in the development of Tetralogy of Fallot have been identified, no genetic diagnosis is available for the majority of patients. Low statistical power may have prevented the identification of further causative genes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cec503e06cf11a7dd3d3d8eebc5f08
https://doi.org/10.1038/s10038-022-01051-y
https://doi.org/10.1038/s10038-022-01051-y