Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Alexandros Kiriazis"'
Autor:
Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently needed. Human induced
Externí odkaz:
https://doaj.org/article/e9849cfeb7e34860b937a7a7a18376a5
Autor:
Sunday Okutachi, Ganesh Babu Manoharan, Alexandros Kiriazis, Christina Laurini, Marie Catillon, Frank McCormick, Jari Yli-Kauhaluoma, Daniel Abankwa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Recently, the highly mutated oncoprotein K-Ras4B (hereafter K-Ras) was shown to drive cancer cell stemness in conjunction with calmodulin (CaM). We previously showed that the covalent CaM inhibitor ophiobolin A (OphA) can potently inhibit K-Ras stemn
Externí odkaz:
https://doaj.org/article/9ea10ad1355044e0be26a3d195bb37dc
Autor:
Alexandros Kiriazis, Riitta L. Vahakoski, Niina M. Santio, Ralica Arnaudova, Sini K. Eerola, Eeva-Marja Rainio, Ingo B. Aumüller, Jari Yli-Kauhaluoma, Päivi J. Koskinen
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/5adecacfef424038b1aacb6842deb179
Autor:
Alexandros Kiriazis, Riitta L Vahakoski, Niina M Santio, Ralica Arnaudova, Sini K Eerola, Eeva-Marja Rainio, Ingo B Aumüller, Jari Yli-Kauhaluoma, Päivi J Koskinen
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55409 (2013)
Oncogenic Pim family kinases are often overexpressed in human hematopoietic malignancies as well as in solid tumours. These kinases contribute to tumorigenesis by promoting cell survival and by enhancing resistance against chemotherapy and radiation
Externí odkaz:
https://doaj.org/article/46eeb9c6ccf14bcfa1e4c1d225862a1c
Autor:
Jianing Liu, Loic Dreano, Keni Vidilaseris, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma, Arthur Lasbleiz, Henri Xhaard, Niklas G. Johansson, Alexandros Kiriazis, Orquidea Marilia de Castro Ribeiro, Adrian Goldman, Ayman Khattab, Seppo Meri
Publikováno v:
Chemmedchem
Inhibition of membrane‐bound pyrophosphatase (mPPase) with small molecules offer a new approach in the fight against pathogenic protozoan parasites. mPPases are absent in humans, but essential for many protists as they couple pyrophosphate hydrolys
Autor:
Niklas G. Johansson, Evgeni Grazhdankin, Loic Dreano, Ayman Khattab, Colin W. G. Fishwick, Ainoleena Turku, Alexandros Kiriazis, Jari Yli-Kauhaluoma, Henri Xhaard, Daniel Ayuso Pérez, Adrian Goldman, Gustav Boije af Gennäs, Aaron Wilkinson, Yuezhou Zhang, Keni Vidilaseris, Matti Tamminen, Seppo Meri
Publikováno v:
ACS Medicinal Chemistry Letters
Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in e.g. malaria. Yet only few nonphosphorus inhibitors have been reported so far. He
Autor:
Christina Oetken-Lindholm, Alok Jaiswal, Tero Aittokallio, Farid Ahmad Siddiqui, Vladimir R. Vukić, Hanna Parkkola, Tiina A. Salminen, Karolina Pavic, Alexandros Kiriazis, Daniel Abankwa
Publikováno v:
Cancers, Vol 13, Iss 927, p 927 (2021)
Cancers
Volume 13
Issue 4
Cancers
Volume 13
Issue 4
The ATP-competitive inhibitors of Hsp90 have been tested predominantly in kinase addicted cancers
however, they have had limited success. A mechanistic connection between Hsp90 and oncogenic K-Ras is not known. Here, we show that K-Ras selectivi
however, they have had limited success. A mechanistic connection between Hsp90 and oncogenic K-Ras is not known. Here, we show that K-Ras selectivi
Autor:
Alexandros Kiriazis, Jörn Steinbeck, Malte Holschen, Benjamin Bockmann, Tobias L. Schulte, Kai-Axel Witt
Publikováno v:
European journal of orthopaedic surgerytraumatology : orthopedie traumatologie. 32(2)
Reverse total shoulder arthroplasty is widely used for the treatment of cuff tear arthropathy. Standard implants consist of a humeral component with an inclination angle of 155° and a glenosphere without lateral offset. Recently, lower inclination a
Autor:
Adrian Goldman, Ainoleena Turku, Henri Xhaard, Niklas G. Johansson, Keni Vidilaseris, Alexandros Kiriazis, Gustav Boije af Gennäs, Jari Yli-Kauhaluoma
Publikováno v:
Journal of Visualized Experiments.
Membrane-bound pyrophosphatases (mPPases) are dimeric enzymes that occur in bacteria, archaea, plants, and protist parasites. These proteins cleave pyrophosphate into two orthophosphate molecules, which is coupled with proton and/or sodium ion pumpin
Autor:
Gustav Boije af Gennäs, Gianmario Scotti, Jari Yli-Kauhaluoma, Henning Henschel, Tapio Kotiaho, Markus Haapala, Sofia M. E. Nilsson, Alexandros Kiriazis
Publikováno v:
The Journal of Organic Chemistry
We have identified the most likely reaction mechanism for oxidizing heptafulvenes to the corresponding tropones by experimental and theoretical investigations. The experimental studies were done by coupling a three-dimensional printed miniaturized re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ec2e78170e3221fe41b7d5bbe38da8
http://hdl.handle.net/10138/306890
http://hdl.handle.net/10138/306890