Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alexandros C Kokotos"'
Autor:
Heshan Peiris, Michael D Duffield, Joao Fadista, Claire F Jessup, Vinder Kashmir, Amanda J Genders, Sean L McGee, Alyce M Martin, Madiha Saiedi, Nicholas Morton, Roderick Carter, Michael A Cousin, Alexandros C Kokotos, Nikolay Oskolkov, Petr Volkov, Tertius A Hough, Elizabeth M C Fisher, Victor L J Tybulewicz, Jorge Busciglio, Pinar E Coskun, Ann Becker, Pavel V Belichenko, William C Mobley, Michael T Ryan, Jeng Yie Chan, D Ross Laybutt, P Toby Coates, Sijun Yang, Charlotte Ling, Leif Groop, Melanie A Pritchard, Damien J Keating
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial
Externí odkaz:
https://doaj.org/article/55d1108814ad40e3b162e4623311cfe8
Autor:
Sasanka Ramanadham, George Kokotos, Maroula G. Kokotou, Xiaoyong Lei, Christiana Mantzourani, Panagiotis K. Politis, Dimitrios Gkikas, Olga G Mountanea, Alexandros C Kokotos, Abdulaziz Almutairi
Publikováno v:
Journal of Medicinal Chemistry. 63:12666-12681
The field of bioactive lipids is ever expanding with discoveries of novel lipid molecules that promote human health. Adopting a lipidomic-assisted approach, two new families of previously unrecognized saturated hydroxy fatty acids (SHFAs), namely, hy
Autor:
George Kokotos, Alexandros C Kokotos, Kai-Chen Wu, Christiana Mantzourani, Maria A. Theodoropoulou, Pirjo Nummela, Dimitrios Gkikas, Ari Ristimäki, David P. Fairlie, Panagiotis K. Politis
Publikováno v:
Bioorganic Chemistry. 114:105132
Hydroxamic acid derivatives constitute an interesting novel class of antitumor agents. Three of them, including vorinostat, are approved drugs for the treatment of malignancies, while several others are currently under clinical trials. In this work,
Autor:
Callista B. Harper, Sarah L. Gordon, Michael A. Cousin, Karen J. Smillie, Jamie R. K. Marland, Alexandros C. Kokotos
Publikováno v:
Kokotos, A, Harper, C, Marland, J, Smillie, K, Cousin, M & Gordon, S 2019, ' Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels ', Journal of Neurochemistry . https://doi.org/10.1111/jnc.14797
Journal of Neurochemistry
Journal of Neurochemistry
The two most abundant molecules on synaptic vesicles (SVs) are synaptophysin and synaptobrevin‐II (sybII). SybII is essential for SV fusion, whereas synaptophysin is proposed to control the trafficking of sybII after SV fusion and its retrieval dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f631067d4644b3a64ea6b23eb20452c
https://hdl.handle.net/20.500.11820/4443ccef-9d5b-4dc2-99e5-f5ded3581c9f
https://hdl.handle.net/20.500.11820/4443ccef-9d5b-4dc2-99e5-f5ded3581c9f
Autor:
Elizabeth C. Davenport, Michael A. Cousin, Alexandros C. Kokotos, Matthias Trost, Julien Peltier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The maintenance of neurotransmission by synaptic vesicle (SV) recycling is critical to brain function. The dominant SV recycling mode during intense activity is activity-dependent bulk endocytosis (ADBE), suggesting it will perform a piv
Autor:
Alexandros C. Kokotos, Thomas H. Gillingwater, Jessica C. Nicholson-Fish, Michael A. Cousin, Karen J. Smillie
Publikováno v:
Neuron
Nicholson-Fish, J C, Kokotos, A C, Gillingwater, T H, Smillie, K J & Cousin, M A 2015, ' VAMP4 is an Essential Cargo Molecule for Activity-Dependent Bulk Endocytosis ', Neuron, vol. 88, no. 5, pp. 973–984 . https://doi.org/10.1016/j.neuron.2015.10.043
Nicholson-Fish, J C, Kokotos, A C, Gillingwater, T H, Smillie, K J & Cousin, M A 2015, ' VAMP4 is an Essential Cargo Molecule for Activity-Dependent Bulk Endocytosis ', Neuron, vol. 88, no. 5, pp. 973–984 . https://doi.org/10.1016/j.neuron.2015.10.043
Summary The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV car
Publikováno v:
Traffic. 16:229-240
Central nerve terminals contain a small number of synaptic vesicles (SVs) that must sustain the fidelity of neurotransmission across a wide range of stimulation intensities. For this to be achieved, nerve terminals integrate a number of complementary
Autor:
Vassilis Yalelis, Alexandros C. Kokotos, George Diallinas, Sotiris Amillis, Mayia Karachaliou, Minoas Evangelinos
Publikováno v:
Molecular Microbiology. 88:301-317
We investigated the role of all arrestin-like proteins of Aspergillus nidulans in respect to growth, morphology, sensitivity to drugs and specifically for the endocytosis and turnover of the uric acid-xanthine transporter UapA. A single arrestin-like
Autor:
Ann Becker, Pinar Coskun, Petr Volkov, Vinder Kashmir, Nikolay Oskolkov, Claire F. Jessup, Heshan Peiris, Michael T. Ryan, William C. Mobley, Amanda J Genders, Nicholas M. Morton, Alyce M. Martin, D. Ross Laybutt, Michael D. Duffield, Michael A. Cousin, João Fadista, Jeng Yie Chan, Sean L. McGee, Leif Groop, Alexandros C. Kokotos, Victor L. J. Tybulewicz, Tertius Hough, Elizabeth M. C. Fisher, Melanie April Pritchard, Jorge Busciglio, P. Toby Coates, Roderick N. Carter, Charlotte Ling, Madiha Saiedi, Sijun Yang, Pavel V. Belichenko, Damien J. Keating
Publikováno v:
Peiris, H; Duffield, MD; Fadista, J; Jessup, CF; Kashmir, V; Genders, AJ; et al.(2016). A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genetics, 12(5). doi: 10.1371/journal.pgen.1006033. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/69g1d108
Peiris, H, Duffield, M D, Fadista, J, Jessup, C F, Kashmir, V, Genders, A J, McGee, S L, Martin, A M, Saiedi, M, Morton, N, Carter, R, Cousin, M A, Kokotos, A, Oskolkov, N, Volkov, P, Hough, T A, Fisher, E M C, Tybulewicz, V L J, Busciglio, J, Coskun, P E, Becker, A, Belichenko, P V, Mobley, W C, Ryan, M T, Chan, J Y, Laybutt, D R, Coates, P T, Yang, S, Ling, C, Groop, L, Pritchard, M A & Keating, D J 2016, ' A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in Type 2 diabetes ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1006033
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
PLoS Genetics
Peiris, H, Duffield, M D, Fadista, J, Jessup, C F, Kashmir, V, Genders, A J, McGee, S L, Martin, A M, Saiedi, M, Morton, N, Carter, R, Cousin, M A, Kokotos, A, Oskolkov, N, Volkov, P, Hough, T A, Fisher, E M C, Tybulewicz, V L J, Busciglio, J, Coskun, P E, Becker, A, Belichenko, P V, Mobley, W C, Ryan, M T, Chan, J Y, Laybutt, D R, Coates, P T, Yang, S, Ling, C, Groop, L, Pritchard, M A & Keating, D J 2016, ' A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in Type 2 diabetes ', PLoS Genetics . https://doi.org/10.1371/journal.pgen.1006033
PLoS Genetics, Vol 12, Iss 5, p e1006033 (2016)
PLoS Genetics
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a79e00f46b9b13910b1e47b75ca457
http://www.escholarship.org/uc/item/69g1d108
http://www.escholarship.org/uc/item/69g1d108
Publikováno v:
Traffic (Copenhagen, Denmark). 16(3)
Central nerve terminals contain a small number of synaptic vesicles (SVs) that must sustain the fidelity of neurotransmission across a wide range of stimulation intensities. For this to be achieved, nerve terminals integrate a number of complementary