Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alexandros, Vakalopoulos"'
Autor:
Marco Potowski, Verena B. K. Kunig, Lukas Eberlein, Mateja Klika Škopić, Alexandros Vakalopoulos, Stefan M. Kast, Andreas Brunschweiger
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
DNA-encoded libraries are a prime technology for target-based small molecule screening. Native DNA used as genetic compound barcode is chemically vulnerable under many reaction conditions. DNA barcodes that are composed of pyrimidine nucleobases, 7-d
Externí odkaz:
https://doaj.org/article/3f3462fa863a4435b7ca5f45117ccc74
Autor:
Frank Wunder, Johannes‐Peter Stasch, Andreas Knorr, Thomas Mondritzki, Damian Brockschnieder, Eva‐Maria Becker‐Pelster, Peter Sandner, Hanna Tinel, Gorden Redlich, Ingo V. Hartung, Alexandros Vakalopoulos, Markus Follmann
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a228384b0e7a00316193cfbba4881cf9
https://doi.org/10.1111/bph.16142
https://doi.org/10.1111/bph.16142
Autor:
Alexandros Vakalopoulos, Frank Wunder, Ingo V. Hartung, Gorden Redlich, Rolf Jautelat, Philipp Buchgraber, Jorma Hassfeld, Alexey V. Gromov, Niels Lindner, Donald Bierer, Jörg Gries, Walter Kroh, Holger Paulsen, Joachim Mittendorf, Dieter Lang, Eva Becker-Pelster, Damian Brockschnieder, Volker Geiss, Volkhart Li, Alexander Straub, Andreas Knorr, Thomas Mondritzki, Hubert Trübel, Marian Raschke, Martina Schaefer, Dirk Thomas, Peter Sandner, Johannes-Peter Stasch, Markus Follmann
Publikováno v:
Journal of Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73f98e7d872f77068d8ae9eeaa915fa4
https://doi.org/10.1021/acs.jmedchem.2c02082
https://doi.org/10.1021/acs.jmedchem.2c02082
Publikováno v:
Organic Letters. 23:5480-5484
DNA-encoded libraries designed around heterocyclic scaffolds have proven highly productive in target-based screening. Here, we show the synthesis of imidazopyridines on a controlled pore glass-coupled DNA oligonucleotide for solid phase-initiated enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e29512b60ba07e15f9fd5cd7a662dc0
https://doi.org/10.1021/acs.orglett.1c01834
https://doi.org/10.1021/acs.orglett.1c01834
Autor:
Peter Sandner, Michael G. Hahn, Johannes-Peter Stasch, Alexandros Vakalopoulos, Markus Follmann
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:203-222
Introduction: In 2013, riociguat a potent and specific stimulator of the soluble guanylyl cyclase (sGC) was approved as first in class sGC stimulator which reflected a first culmination of intense research and development efforts starting in the mid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03df67546547b198af1fd341b189fd08
https://doi.org/10.1080/13543776.2021.1866538
https://doi.org/10.1080/13543776.2021.1866538
Autor:
Jörg Hüser, Lisa Dietz, Alexandros Vakalopoulos, Roland Seifert, Ilka Mathar, Peter Sandner, Shalini M Krishnan, Petra Haning, Elke Hartmann, Johannes Nordlohne
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8016, p 8016 (2021)
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8016, p 8016 (2021)
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder, affecting one in 3500 to 5000 boys worldwide. The NO-sGC-cGMP pathway plays an important role in skeletal muscle function, primarily by improving blood flow and ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9b54df1cc326e6680b6112552affdd
Autor:
Stefan M. Kast, Lukas Eberlein, Alexandros Vakalopoulos, Andreas Brunschweiger, Marco Potowski, Verena B. K. Kunig
Publikováno v:
Angewandte Chemie (International Ed. in English)
DNA‐encoded compound libraries are a widely used small molecule screening technology. One important aim in library design is the coverage of chemical space through structurally diverse molecules. Yet, the chemical reactivity of native DNA barcodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b5a1c7955b2d2d87e08c807dd97ef4
https://pubmed.ncbi.nlm.nih.gov/34153170
https://pubmed.ncbi.nlm.nih.gov/34153170
Autor:
Katja Zimmermann, Nicole Diedrichs, Walter Hübsch, Alexandros Vakalopoulos, Hans-Georg Lerchen, Thomas Kramer, Frank Süssmeier, Barbara Albrecht-Küpper, Raimund Kast, Ursula Krenz, Daniel Meibom, Peter G. Nell, Joachim Mittendorf
Publikováno v:
ChemMedChem. 12:728-737
Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A1 receptors (A1Rs) has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::980d62cd9e6ae9380c0011ac41a9a756
https://doi.org/10.1002/cmdc.201700151
https://doi.org/10.1002/cmdc.201700151
Autor:
Daniel, Meibom, Barbara, Albrecht-Küpper, Nicole, Diedrichs, Walter, Hübsch, Raimund, Kast, Thomas, Krämer, Ursula, Krenz, Hans-Georg, Lerchen, Joachim, Mittendorf, Peter G, Nell, Frank, Süssmeier, Alexandros, Vakalopoulos, Katja, Zimmermann
Publikováno v:
ChemMedChem. 12(10)
Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f63ae1aaa2ba4a447ae5d3791b0a6ba2
https://pubmed.ncbi.nlm.nih.gov/28488817
https://pubmed.ncbi.nlm.nih.gov/28488817
Autor:
Frank-Thorsten Hafner, Carsten Schmeck, Roland Heinig, Alexandros Vakalopoulos, Hilmar Bischoff, Klemens Lustig, Klaus Buehner, Stefan Willmann, Volkhart Min-Jian Li, Olaf Weber
Publikováno v:
British Journal of Clinical Pharmacology. 73:219-231
The purpose of this work was to support the prediction of a potentially effective dose for the CETP-inhibitor, BAY 60-5521, in humans.A combination of allometric scaling of the pharmacokinetics of the CETP-inhibitor BAY 60-5521 with pharmacodynamic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bef16ac0e693cddb037a092a49ba25
https://doi.org/10.1111/j.1365-2125.2011.04064.x
https://doi.org/10.1111/j.1365-2125.2011.04064.x