Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alexandrina Mateeva"'
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-10 (2024)
The detection of pyrrole rings in numerous organic compounds with various pharmacological activities, emphasizes its huge importance in medicinal chemistry. Thus, the synthesis of pyrroles continues to arouse interest and Paal-Knorr condensation is c
Externí odkaz:
https://doaj.org/article/1d79dcf1c5ee4607a7014d9d75a9a6c3
Autor:
Emilio Mateev, Ali Irfan, Alexandrina Mateeva, Magdalena Kondeva-Burdina, Maya Georgieva, Alexander Zlatkov
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-7 (2024)
Virtual screening is emerging as a highly applied technique and gained prominence as widely used method for the search and identification of potential hits, significantly reducing the time needed to discover novel and effective compounds compared to
Externí odkaz:
https://doaj.org/article/284f397e290449b8b63f3a3f2d7f8a7c
Publikováno v:
Pharmacia, Vol 70, Iss 4, Pp 1015-1018 (2023)
In the current study, RP-HPLC method for evaluation of 2 pyrrol-based hydrazones in isolated rat synaptosomes was optimized and validated according to ICH guidelines. The synaptosomes were obtained by multiple centrifugations with Percoll reagent and
Externí odkaz:
https://doaj.org/article/6051e0b160914834958475c594e656df
Autor:
Emilio Mateev, Magdalena Kondeva-Burdina, Maya Georgieva, Alexandrina Mateeva, Iva Valkova, Virginia Tzankova, Alexander Zlatkov
Publikováno v:
Scientia Pharmaceutica, Vol 92, Iss 2, p 18 (2024)
Considering the complex pathogenesis of Alzheimer’s disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target approach. Thus, a series o
Externí odkaz:
https://doaj.org/article/d09fa31abe3f400596318366e54b4d5f
Autor:
Alexandrina Mateeva, Magdalena Kondeva-Burdina, Emilio Mateev, Paraskev Nedialkov, Karolina Lyubomirova, Lily Peikova, Maya Georgieva, Alexander Zlatkov
Publikováno v:
Molecules, Vol 29, Iss 7, p 1474 (2024)
In the current study, chromatographic and in silico techniques were applied to investigate the biotransformation of ethyl 5-(4-bromophenyl)-1-(2-(2-(2-hydroxybenzylidene) hydrazinyl)-2-oxoethyl)-2-methyl-1H-pyrrole-3-carboxylate (11b) in hepatocytic
Externí odkaz:
https://doaj.org/article/fc3133a8f95c4afba2e7664c4aff8e2d
Autor:
Alexandrina Mateeva, Magdalena Kondeva-Burdina, Lily Peikova, Silvia Guncheva, Alexander Zlatkov, Maya Georgieva
Publikováno v:
Heliyon, Vol 9, Iss 1, Pp e12706- (2023)
The current study is focused on investigation and quantitation of seven commercially available on the Bulgarian market food supplements, containing multivitamin mixtures of water-soluble and fat-soluble vitamins. In addition, a second fermentation br
Externí odkaz:
https://doaj.org/article/52a3239f0cb940a1bb1f00a7420123ee
Publikováno v:
Pharmacia, Vol 69, Iss 1, Pp 151-155 (2022)
Nutritional supplements are concentrated sources of nutrients, vitamins and minerals with a nutritional or physiological effect, the purpose of which is to supplement the normal nutritional balance. A necessity of the health risk associated with thei
Externí odkaz:
https://doaj.org/article/4ff3757356434ddf83f375efc6b94818
Publikováno v:
Pharmacia, Vol 69, Iss 1, Pp 15-20 (2022)
In this research, a new rapid PR- HPLC method was developed for the determination of metabolites in isolated rat hapatocytes. The chromatographic parameters, including the stationary and mobile phases, outlet pressure, temperature and flow rate, were
Externí odkaz:
https://doaj.org/article/0d1088daa9464a8a8934ae3e7de7d2e3
Autor:
Diana Tzankova, Hristina Kuteva, Emilio Mateev, Denitsa Stefanova, Alime Dzhemadan, Yordan Yordanov, Alexandrina Mateeva, Virginia Tzankova, Magdalena Kondeva-Burdina, Alexander Zlatkov, Maya Georgieva
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1198 (2023)
A series of ten new hydrazide–hydrazone derivatives bearing a pyrrole ring were synthesized and structurally elucidated through appropriate spectral characteristics. The target hydrazones were assessed for radical scavenging activity through 1,1-di
Externí odkaz:
https://doaj.org/article/ea4674433cea4832b4457cacc302e0ac
Autor:
Emilio Mateev, Maya Georgieva, Alexandrina Mateeva, Alexander Zlatkov, Shaban Ahmad, Khalid Raza, Vasco Azevedo, Debmalya Barh
Publikováno v:
Molecules, Vol 28, Iss 12, p 4814 (2023)
With the significant growth of patients suffering from neurodegenerative diseases (NDs), novel classes of compounds targeting monoamine oxidase type B (MAO-B) are promptly emerging as distinguished structures for the treatment of the latter. As a pro
Externí odkaz:
https://doaj.org/article/3b390f02030847739d549c581e261e5d