Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alexandria P. Eiken"'
Autor:
Alexandria P. Eiken, Elizabeth Schmitz, Erin M. Drengler, Audrey L. Smith, Sydney A. Skupa, Kabhilan Mohan, Sandeep Rana, Sarbjit Singh, Jayapal Reddy Mallareddy, Grinu Mathew, Amarnath Natarajan, Dalia El-Gamal
Publikováno v:
Hemato, Vol 5, Iss 3, Pp 321-339 (2024)
Background: B-cell receptor (BCR) signaling is a central driver in chronic lymphocytic leukemia (CLL), along with the activation of pro-survival pathways (e.g., NF-κB) and aberrant anti-apoptotic mechanisms (e.g., BCL2) culminating to CLL cell survi
Externí odkaz:
https://doaj.org/article/d7db08149c6147c49528ecc49959d72e
Autor:
Alexandria P. Eiken, Dalia El-Gamal
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 557 (2023)
In the era of targeted therapies, researchers have aimed to uncover the molecular drivers of malignant pathogenesis in lymphoid malignancies in an endeavor to develop effective therapeutic strategies [...]
Externí odkaz:
https://doaj.org/article/b9d65a0252d3474b81cfd8a46a2762e9
Autor:
Audrey L. Smith, Alexandria P. Eiken, Sydney A. Skupa, Dalia Y. Moore, Lelisse T. Umeta, Lynette M. Smith, Elizabeth R. Lyden, Christopher R. D’Angelo, Avyakta Kallam, Julie M. Vose, Tatiana G. Kutateladze, Dalia El-Gamal
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6712 (2022)
B-cell chronic lymphocytic leukemia (CLL) results from intrinsic genetic defects and complex microenvironment stimuli that fuel CLL cell growth through an array of survival signaling pathways. Novel small-molecule agents targeting the B-cell receptor
Externí odkaz:
https://doaj.org/article/ea779f77bf3145bca09d096c17da4db1
Autor:
Alexandria P Eiken, Sydney A Skupa, Neecole Brown, Audrey L Smith, Sarbjit Singh, Sandeep Rana, Amarnath Natarajan, Dalia ElGamal
Publikováno v:
Blood. 140:8872-8873
Autor:
Audrey L. Smith, Alexandria P. Eiken, Sydney A. Skupa, Christopher R. D'Angelo, Avyakta Kallam, Matthew A. Lunning, Gregory Bociek, Julie M. Vose, Ben Powell, Gideon Bollag, Dalia El-Gamal
Publikováno v:
Cancer Research. 83:6396-6396
Background: The chronic lymphocytic leukemia (CLL) tumor microenvironment (TME) is laden with hyporesponsive T-cells that permit disease persistence. Yet, redundant TME immunosuppressive mechanisms and epigenetic maintenance of T-cell exhaustion limi
Autor:
Sydney A. Skupa, Gideon Bollag, Avyakta Kallam, Ben Powell, Audrey L Smith, Dalia Moore, Gregory Bociek, Christopher D'Angelo, Julie M. Vose, Alexandria P Eiken, Dalia ElGamal, Matthew A. Lunning
Publikováno v:
Blood. 138:3715-3715
Introduction : Chronic Lymphocytic Leukemia (CLL) is characterized by the clonal expansion of mature CD19+/CD5+ lymphocytes in the peripheral blood and secondary lymphoid organs. The accumulation of B-CLL cells yields profound immune defects in the C
Autor:
Alexandria P Eiken, Sarbjit Singh, Audrey L Smith, Sandeep Rana, Amarnath Natarajan, Dalia ElGamal, Sunandini Sharma
Publikováno v:
Blood. 138:1186-1186
Introduction: Chronic lymphocytic leukemia (CLL) is an incurable, heterogenetic disease dependent on B cell receptor (BCR) signaling with subsequent nuclear factor-kappa B (NF-κB) activation resulting in the evasion of apoptosis and enhanced maligna