Výsledky vyhledávání - "Alexandria M Taber"

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

Autor: Ericka P Pegues, Ilona Jileaeva, Alexandria M Taber, Sirkka B. Stephan, Charles L. Sentman, Matthias Stephan

Publikováno v: Nature biotechnology

Although adoptive T-cell therapy holds promise for the treatment of many cancers, its clinical utility has been limited by problems in delivering targeted lymphocytes to tumor sites, and the cells' inefficient expansion in the immunosuppressive tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a950c84e028eb051b0a55a474c1221
https://doi.org/10.1038/nbt.3104

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Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model

Autor: Emily E. Reister, Marina Guenza, Elaine deLorimier, Kush Sharma, J. Andrew Berglund, Peter K. Todd, Jeremy Copperman, Leslie A. Coonrod, Alexandria M Taber

Publikováno v: Nucleic Acids Research

CUG repeat expansions in the 3′ UTR of dystrophia myotonica protein kinase (DMPK) cause myotonic dystrophy type 1 (DM1). As RNA, these repeats elicit toxicity by sequestering splicing proteins, such as MBNL1, into protein–RNA aggregates. Structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87f1fce6fde3a842f1410c4fc6ba3a9
https://doi.org/10.1093/nar/gku941

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Coexpression of Human α- and Circularly Permuted β-Globins Yields a Hemoglobin with Normal R State but Modified T State Properties

Autor: John S. Olson, Danielle H. Lin, Alexandria M. Taber, Anna L. Asmundson, Adella van der Walde, Spencer J. Anthony-Cahill

Publikováno v: Biochemistry. 48:5456-5465

For the first time, a circularly permuted human beta-globin (cpbeta) has been coexpressed with human alpha-globin in bacterial cells and shown to associate to form alpha-cpbeta hemoglobin in solution. Flash photolysis studies of alpha-cpbeta show mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b7a125c8af356d4c938739af7de4e0
https://doi.org/10.1021/bi900216p

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