Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexandria L. Fink"'
Autor:
Hiroaki Wakimoto, Daniel P. Cahill, Mara V.A. Koerner, Julie J. Miller, Juri Kiyokawa, Alexandria L. Fink, Fumi Higuchi
Figure S1. A compound screen identifies Volasertib as potently cytotoxic to MSH6-deficient glioblastoma cells. Figure S2. The effects of temozolomide and PLK1 inhibitors on glioblastoma cells with and without MSH6 knockdown. Figure S3. Combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cd718b2ea402264d9a0713209e765a
https://doi.org/10.1158/1535-7163.22505719
https://doi.org/10.1158/1535-7163.22505719
Autor:
Hiroaki Wakimoto, Daniel P. Cahill, Mara V.A. Koerner, Julie J. Miller, Juri Kiyokawa, Alexandria L. Fink, Fumi Higuchi
Mismatch repair (MMR) deficiency through MSH6 inactivation has been identified in up to 30% of recurrent high-grade gliomas, and represents a key molecular mechanism underlying the acquired resistance to the alkylating agent temozolomide (TMZ). To de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45088be653fc7c4ec45fccf45ecbba8
https://doi.org/10.1158/1535-7163.c.6538159.v1
https://doi.org/10.1158/1535-7163.c.6538159.v1
Autor:
Priscilla K. Brastianos, Hiroaki Wakimoto, Daniel P. Cahill, Scott L. Carter, Maria Martinez-Lage, Anita Giobbie-Hurder, Megha Subramanian, Jianfang Ning, Gregory R. Wojtkiewicz, Stephen P. Schmidt, Tristan Penson, Matthew Lastrapes, Ivanna V. Bihun, Alexandria L. Fink, Benjamin M. Kuter, Christopher A. Alvarez-Breckenridge, Franziska M. Ippen
Western blot analysis of p-p44/42 MAPK (Erk1/2) (Thr202/Tyr204), p-MEK1/2 (Ser217/221), p-p90RSK (Ser380), p-MSK1 (Thr581) in JIMT-1 BR-3, MDA-MB-361, MDA-MB-231 BrM2 and BS-004 cell lines treated with GDC-0084 in increasing concentrations for a tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc25e6af1c18a10c51316128945a202
https://doi.org/10.1158/1078-0432.22470510.v1
https://doi.org/10.1158/1078-0432.22470510.v1
Autor:
Priscilla K. Brastianos, Hiroaki Wakimoto, Daniel P. Cahill, Scott L. Carter, Maria Martinez-Lage, Anita Giobbie-Hurder, Megha Subramanian, Jianfang Ning, Gregory R. Wojtkiewicz, Stephen P. Schmidt, Tristan Penson, Matthew Lastrapes, Ivanna V. Bihun, Alexandria L. Fink, Benjamin M. Kuter, Christopher A. Alvarez-Breckenridge, Franziska M. Ippen
Purpose:Previous studies have shown that the PI3K/Akt/mTOR pathway is activated in up to 70% of breast cancer brain metastases, but there are no approved agents for affected patients. GDC-0084 is a brain penetrant, dual PI3K/mTOR inhibitor that has s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4462a59ba850ac6cd3caddecb662fc76
https://doi.org/10.1158/1078-0432.c.6527592
https://doi.org/10.1158/1078-0432.c.6527592
Autor:
Tetsuya Yamamoto, Koichi Ichimura, Motoo Nagane, Tracy T. Batchelor, Andrew S. Chi, Hiroaki Wakimoto, Daniel P. Cahill, Hiroyuki Mano, Shoji Yamanaka, Akihide Ryo, Yukihiko Fujii, Julie J. Miller, Ichio Aoki, Hidetoshi Murata, Jun Suenaga, Ryohei Miyazaki, Makoto Ohtake, Mayuko Nishi, Naoki Ikegaya, Manabu Natsumeda, Shilpa S. Tummala, Alexandria L. Fink, Kentaro Ohki, Naoko Udaka, Norio Shiba, Yuko Matsushita, Jun Watanabe, Akio Miyake, Toshihide Ueno, Yukie Yoshii, Jo Sasame, Taishi Nakamura, Nobuyoshi Sasaki, Masahito Kawazu, Yohei Miyake, Kensuke Tateishi
Supplementary document
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afde19d188d88bc6781a464b38f1d98
https://doi.org/10.1158/0008-5472.22426684.v1
https://doi.org/10.1158/0008-5472.22426684.v1
Autor:
Daniel P. Cahill, Hiroaki Wakimoto, A. John Iafrate, Andrew S. Chi, Tracy T. Batchelor, Koichi Ichimura, Tetsuya Yamamoto, Dora Dias-Santagata, William T. Curry, Shoji Yamanaka, Akihide Ryo, Hidetoshi Murata, Naoko Udaka, Hiroki Taguchi, Takashi Shuto, Shigeo Mukaihara, Shigeo Matsunaga, Ryogo Minamimoto, Takahiro Tanaka, Kenji Fujimoto, Jo Sasame, Yohei Miyake, Mara V.A. Koerner, Nina Lelic, Alexandria L. Fink, Shilpa S. Tummala, Julie J. Miller, Mayuko Nishi, Shigeta Miyake, Yuko Matsushita, Erik A. Williams, Tareq A. Juratli, Taishi Nakamura, Kensuke Tateishi
Supplementary Table 1 Primers used for PCR amplification and sequencing Supplementary Table 2 Results of Multiplex PCR based MGH SNAPShot assay, Pyrosequencing and Sanger sequencing in YMG6 patient and xenograft cells Supplementary Table 3 Analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7d91b47772b4be6558d40bc67a5fe9
https://doi.org/10.1158/1078-0432.22472153
https://doi.org/10.1158/1078-0432.22472153
Autor:
Tetsuya Yamamoto, Koichi Ichimura, Motoo Nagane, Tracy T. Batchelor, Andrew S. Chi, Hiroaki Wakimoto, Daniel P. Cahill, Hiroyuki Mano, Shoji Yamanaka, Akihide Ryo, Yukihiko Fujii, Julie J. Miller, Ichio Aoki, Hidetoshi Murata, Jun Suenaga, Ryohei Miyazaki, Makoto Ohtake, Mayuko Nishi, Naoki Ikegaya, Manabu Natsumeda, Shilpa S. Tummala, Alexandria L. Fink, Kentaro Ohki, Naoko Udaka, Norio Shiba, Yuko Matsushita, Jun Watanabe, Akio Miyake, Toshihide Ueno, Yukie Yoshii, Jo Sasame, Taishi Nakamura, Nobuyoshi Sasaki, Masahito Kawazu, Yohei Miyake, Kensuke Tateishi
Supplementary Figure S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b1338f8d5689c79fdc273eca42814b
https://doi.org/10.1158/0008-5472.22426681.v1
https://doi.org/10.1158/0008-5472.22426681.v1
Autor:
Daniel P. Cahill, Hiroaki Wakimoto, A. John Iafrate, Andrew S. Chi, Tracy T. Batchelor, Koichi Ichimura, Tetsuya Yamamoto, Dora Dias-Santagata, William T. Curry, Shoji Yamanaka, Akihide Ryo, Hidetoshi Murata, Naoko Udaka, Hiroki Taguchi, Takashi Shuto, Shigeo Mukaihara, Shigeo Matsunaga, Ryogo Minamimoto, Takahiro Tanaka, Kenji Fujimoto, Jo Sasame, Yohei Miyake, Mara V.A. Koerner, Nina Lelic, Alexandria L. Fink, Shilpa S. Tummala, Julie J. Miller, Mayuko Nishi, Shigeta Miyake, Yuko Matsushita, Erik A. Williams, Tareq A. Juratli, Taishi Nakamura, Kensuke Tateishi
Supplementary Figure 1. A, Hematoxylin and eosin, Ki-67, and IDH1R132H staining in each specimen. B, Sanger sequencing, immunohistochemical analysis, pyrosequencing, and FISH to identify YMG6 tumors as oligodendroglial tumors. C, Multiplex Ligation-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a743f40c9014dac77d9dcc682ff454e
https://doi.org/10.1158/1078-0432.22472156
https://doi.org/10.1158/1078-0432.22472156
Autor:
Tetsuya Yamamoto, Koichi Ichimura, Motoo Nagane, Tracy T. Batchelor, Andrew S. Chi, Hiroaki Wakimoto, Daniel P. Cahill, Hiroyuki Mano, Shoji Yamanaka, Akihide Ryo, Yukihiko Fujii, Julie J. Miller, Ichio Aoki, Hidetoshi Murata, Jun Suenaga, Ryohei Miyazaki, Makoto Ohtake, Mayuko Nishi, Naoki Ikegaya, Manabu Natsumeda, Shilpa S. Tummala, Alexandria L. Fink, Kentaro Ohki, Naoko Udaka, Norio Shiba, Yuko Matsushita, Jun Watanabe, Akio Miyake, Toshihide Ueno, Yukie Yoshii, Jo Sasame, Taishi Nakamura, Nobuyoshi Sasaki, Masahito Kawazu, Yohei Miyake, Kensuke Tateishi
Primary central nervous system lymphoma (PCNSL) is an isolated type of lymphoma of the central nervous system and has a dismal prognosis despite intensive chemotherapy. Recent genomic analyses have identified highly recurrent mutations of MYD88 and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa02d6f07add20318aabdac38573667
https://doi.org/10.1158/0008-5472.c.6512419
https://doi.org/10.1158/0008-5472.c.6512419
Autor:
Priscilla K. Brastianos, Hiroaki Wakimoto, Daniel P. Cahill, Scott L. Carter, Maria Martinez-Lage, Anita Giobbie-Hurder, Megha Subramanian, Jianfang Ning, Gregory R. Wojtkiewicz, Stephen P. Schmidt, Tristan Penson, Matthew Lastrapes, Ivanna V. Bihun, Alexandria L. Fink, Benjamin M. Kuter, Christopher A. Alvarez-Breckenridge, Franziska M. Ippen
Photomicrographs illustrating p-MEK1/2 (Ser221) and p-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) expression in mouse brains harboring either JIMT-1 BR-3 or MDA-MB-231 BrM2 intracranial tumors, stratified by treatment with sham or GDC-0084.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe3b839cacdc04735a7be46993e31f4
https://doi.org/10.1158/1078-0432.22470504.v1
https://doi.org/10.1158/1078-0432.22470504.v1