Výsledky vyhledávání - "Alexandria Juffre"

Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats

Autor: Adrian Zietara, Denisha R. Spires, Alexandria Juffre, Hannah M. Costello, G. Ryan Crislip, Lauren G. Douma, Vladislav Levchenko, Lashodya V. Dissanayake, Christine A. Klemens, Oksana Nikolaienko, Aron M. Geurts, Michelle L. Gumz, Alexander Staruschenko

Publikováno v: Hypertension (Dallas, Tex. : 1979). 79(11)

Background: Circadian rhythms play an essential role in physiological function. The molecular clock that underlies circadian physiological function consists of a core group of transcription factors, including the protein PER1 (Period1). Studies in mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7209767218d6667cfb7765fd7380930
https://pubmed.ncbi.nlm.nih.gov/36093781

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Circadian clocks of the kidney: function, mechanism, and regulation

Autor: Hannah M. Costello, Jermaine G. Johnston, Alexandria Juffre, G. Ryan Crislip, Michelle L. Gumz

Publikováno v: Physiological Reviews. 102:1669-1701

An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal processes. In this review, we summarize what is curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbb4ac75afaf7d127c1c2eda17b8259
https://doi.org/10.1152/physrev.00045.2021

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Adrenal-Kidney Clock Crosstalk: Utilizing Tissue-Specific Clock KO Models

Autor: Hannah Costello, G. Ryan Crislip, Annalisse Mckee, Kit-Yan Cheng, Alexandria Juffre, Jermaine Johnstone, Lauren Douma, Michelle Gumz

Publikováno v: Physiology. 38

Circadian rhythms are 24-hour oscillations that regulate many physiological functions including hormone signaling and electrolyte excretion. These rhythms are coordinated by a molecular clock, comprised of 4 key core clock proteins – BMAL1, CLOCK,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d385dca03e45b841222873cd584d535
https://doi.org/10.1152/physiol.2023.38.s1.5731958

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Sex-specific differences in kidney clock gene expression in mice in response to a low potassium, high salt diet

Autor: Hannah Costello, Kit-Yan Cheng, Jermaine Johnstone, Alexandria Juffre, Lauren Douma, Michelle Gumz, G. Ryan Crislip

Publikováno v: Physiology. 38

Clinical studies demonstrate that women have exacerbated salt-sensitive blood pressure (BP) responses compared to men. However, most studies examining the molecular mechanisms involved in salt-sensitive hypertension focus on males. Accumulating evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::077f817c88cf69fb891937639fb40e0a
https://doi.org/10.1152/physiol.2023.38.s1.5734672

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Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior

Autor: Hannah M Costello, G Ryan Crislip, Kit-Yan Cheng, I Jeanette Lynch, Alexandria Juffre, Phillip Bratanatawira, Annalisse Mckee, Ryanne S Thelwell, Victor M Mendez, Charles S Wingo, Lauren G Douma, Michelle L Gumz

Publikováno v: Function. 4

Brain and muscle ARNT-like 1 (BMAL1) is a core circadian clock protein and transcription factor that regulates many physiological functions, including blood pressure (BP). Male global Bmal1 knockout (KO) mice exhibit ∼10 mmHg reduction in BP, as we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2348ff19c69120aa78b2ae811147322c
https://doi.org/10.1093/function/zqad001

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Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems

Autor: G. Ryan Crislip, Jermaine G. Johnston, Lauren G. Douma, Hannah M. Costello, Alexandria Juffre, Kyla Boyd, Wendy Li, Cheoting C. Maugans, Miguel Gutierrez‐Monreal, Karyn A. Esser, Andrew J. Bryant, Andrew C. Liu, Michelle L. Gumz

Publikováno v: Comprehensive Physiology. :2769-2798

Nearly every system within the body contains an intrinsic cellular circadian clock. The circadian clock contributes to the regulation of a variety of homeostatic processes in mammals through the regulation of gene expression. Circadian disruption of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4537d5957dcfab201f4f2306a4116945
https://doi.org/10.1002/cphy.c210011

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The Circadian Clock Protein PER1 is Important in Maintaining Endothelin Axis Regulation in Dahl Salt Sensitive Rats

Autor: Hannah M. Costello, Alexandria Juffre, Kit-Yan Cheng, Phillip Bratanatawira, G. Ryan Crislip, Adrian Zietara, Denisha R. Spires, Alexander Staruschenko, Lauren G. Douma, Michelle L. Gumz

Publikováno v: Canadian journal of physiology and pharmacology.

Endothelin-1 (ET-1) is a peptide hormone that acts on its receptors to regulate sodium handling in the kidney's collecting duct. Dysregulation of the endothelin axis is associated with various diseases, including salt-sensitive hypertension and chron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f64c6ac17854d0ebbfbe8a1897b52a
https://pubmed.ncbi.nlm.nih.gov/36450128

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Abstract 096: Adrenal-specific KO Of The Circadian Clock Protein Bmal1 Alters Blood Pressure Rhythm

Autor: Hannah M Costello, Gene R Crislip, KitYan Cheng, Irma J Matheny, Annalisse Mckee, Alexandria Juffre, Phillip Bratanatawira, Victor M Mendez, Charles Wingo, Lauren Douma, Michelle L Gumz

Publikováno v: Hypertension. 79

BMAL1 is a core circadian clock protein that regulates most physiological functions, including blood pressure (BP). Global BMAL1 knockout (KO) male mice exhibit reduced, non-dipping BP and loss of diurnal rhythm of renal sodium (Na) excretion. Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9e09963d7eed2399ad5810fe7bb6432
https://doi.org/10.1161/hyp.79.suppl_1.096

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