Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexandria Harrison"'
Autor:
Daniel Doheny, Sara Manore, Sherona R. Sirkisoon, Dongqin Zhu, Noah R. Aguayo, Alexandria Harrison, Mariana Najjar, Marlyn Anguelov, Anderson O’Brien Cox, Cristina M. Furdui, Kounosuke Watabe, Thomas Hollis, Alexandra Thomas, Roy Strowd, Hui-Wen Lo
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4256
The goal of this study is to identify pharmacological inhibitors that target a recently identified novel mediator of breast cancer brain metastasis (BCBM), truncated glioma-associated oncogene homolog 1 (tGLI1). Inhibitors of tGLI1 are not yet availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0cfbebb491e653607578294e7940f2
https://doi.org/10.3390/cancers14174256
https://doi.org/10.3390/cancers14174256
Publikováno v:
Diabetes. 69
Dietary iron overload is linked to increase risk of type 2 diabetes (T2D), with iron significantly affecting insulin sensitivity/secretion, hepatic glucose production, as well as other physiological responses altered in T2D. These effects are in part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c24da08e01b688bdef485cc52aec2f
https://doi.org/10.2337/db20-1871-p
https://doi.org/10.2337/db20-1871-p
Autor:
Richard L. Carpenter, Kounosuke Watabe, Guangxu Jin, Hui-Wen Lo, Tadas Rimkus, Alexandria Harrison, Ashley Anderson, Sherona Sirkisoon, Allison M. Lange
Publikováno v:
Oncogene
Signal transducer and activator of transcription 3 (STAT3), glioma oncogene homolog 1 (GLI1), and truncated GLI1 (tGLI1) are oncogenic transcription factors playing important roles in breast cancer. tGLI1 is a gain-of-function GLI1 isoform. Whether S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80aefd3f3901a47e43ad4c2940736af9
https://doi.org/10.1038/s41388-018-0132-4
https://doi.org/10.1038/s41388-018-0132-4
Autor:
Donald A. McClain, Robert C. Cooksey, Ielizaveta Bychkova, Sandy Sink, Felipe Lorenzo, Kylie Kavanagh, Herbert L. Bonkovsky, Manish S. Bharadwaj, Soh-Hyun Lee, Shalini Jain, Nuwan T. Meegalla, Alexandria Harrison, Lipika Salaye, George L. Donati, Ashley T. Davis, Katherine Turnbull, Alexander J. Kovalic
Publikováno v:
Nutrients
Volume 11
Issue 9
Nutrients, Vol 11, Iss 9, p 2172 (2019)
Volume 11
Issue 9
Nutrients, Vol 11, Iss 9, p 2172 (2019)
High tissue iron levels are a risk factor for multiple chronic diseases including type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). To investigate causal relationships and underlying mechanisms, we used an established NAF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2636f1ce6907f8933d4d6fdb1e3b92
http://europepmc.org/articles/PMC6769937
http://europepmc.org/articles/PMC6769937
Publikováno v:
Diabetes. 68
Excess intake of the micronutrient iron has been associated with increased risk of type 2 diabetes (T2D). Sentinel abnormalities observed in T2D are reduced insulin sensitivity, impaired insulin secretion, and increased hepatic glucose production. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6abf3b487ece1312e38484c2e5b5a03f
https://doi.org/10.2337/db19-1916-p
https://doi.org/10.2337/db19-1916-p
Publikováno v:
Diabetes. 68
Obesity and type 2 diabetes are co-morbidities, and their prevalence is continually growing. In obesity, in the face of lipid accumulation, adipose tissue become hypoxic with reduced blood flow, accompanied by low grade inflammation and insulin resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::680a9d3a7417acd4ca0e8b7bf0902d8c
https://doi.org/10.2337/db19-1133-p
https://doi.org/10.2337/db19-1133-p
Autor:
Adrianna H. Masters, Noah R. Aguayo, Kounosuke Watabe, Alexandria Harrison, Tadas Rimkus, Roy E. Strowd, Marlyn Anguelov, Dongqin Zhu, Sara G. Manore, Alexandra Thomas, Hui-Wen Lo, Linda J. Metheny-Barlow, Sherona Sirkisoon, Fei Xing, Daniel Doheny
Publikováno v:
Cancer Research. 80:5025-5025
Breast cancer is the second leading cause of brain metastases in women; patients with breast cancer brain metastasis (BCBM) survive only 6-18 months following diagnosis. Current standard of care options for BCBM include stereotactic radiosurgery, who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fd4ed0d29b8ef997bea8861510e4201
https://doi.org/10.1158/1538-7445.am2020-5025
https://doi.org/10.1158/1538-7445.am2020-5025
Autor:
Mary E. Comeau, Shalini Jain, Swapan K Das, Neeraj K. Sharma, Donald A. McClain, Carl D. Langefeld, Felipe R. Lorenzo, Alexandria Harrison, Lipika Salaye
Publikováno v:
The Journal of clinical endocrinology and metabolism. 103(11)
CONTEXT: Excessive body iron stores are a risk factor for decreased insulin sensitivity (S(I)) and diabetes. We hypothesized that transcriptional dysregulation of genes involved in iron metabolism in adipocytes causes insulin resistance. OBJECTIVE AN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e922d68ee26d11a95937894ce9b616
https://pubmed.ncbi.nlm.nih.gov/30099506
https://pubmed.ncbi.nlm.nih.gov/30099506
Autor:
Sherona Sirkisoon, Kounosuke Watabe, Anderson Ashley, Hui-Wen Lo, Richard L. Carpenter, Guangxu Jin, Alexandria Harrison, Allison M. Lange, Rimkus Tadas
Publikováno v:
Cancer Research. 78:5415-5415
Patients with triple-negative (TN) and HER2-enriched (HER2) breast cancers have high rates of metastasis, which accounts for 90% mortality for these patients, highlighting the need for improved therapeutic targets. The oncogenic transcription factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6763ea61fb12a11b459d55a72b4bf4ee
https://doi.org/10.1158/1538-7445.am2018-5415
https://doi.org/10.1158/1538-7445.am2018-5415