Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alexandria A. Oviatt"'
Publikováno v:
Biochemistry
The extensive length, compaction, and interwound nature of DNA, together with its controlled and restricted movement in eukaryotic cells, create a number of topological issues that profoundly affect all of the functions of the genetic material. Topoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f8c90fde509bf9c721c76f42b7e7b0
https://europepmc.org/articles/PMC8209676/
https://europepmc.org/articles/PMC8209676/
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603222
Agarose gel electrophoresis is one of the most straightforward techniques that can be used to differentiate between topoisomers of closed circular DNA molecules. Generally, the products of reactions that monitor the interconversion of DNA between neg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcd447e6ca4d8fe406e61729512da70
https://doi.org/10.1007/978-1-0716-0323-9_2
https://doi.org/10.1007/978-1-0716-0323-9_2
Autor:
Keir C. Neuman, Alexandria A. Oviatt, Elizabeth G. Gibson, Pan F. Chan, Neil Osheroff, Monica Cacho
Publikováno v:
Biochemistry
Gyrase and topoisomerase IV are the targets of fluoroquinolone antibacterials. However, the rise in antimicrobial resistance has undermined the clinical use of this important drug class. Therefore, it is critical to identify new agents that maintain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40db2404ec09acb963bc63ab9dff8fb0
https://europepmc.org/articles/PMC7450530/
https://europepmc.org/articles/PMC7450530/
Autor:
Princess Onuorah, Anna Minarini, Marco De Vivo, Kendra R. Vann, Elirosa Minniti, Neil Osheroff, Alexandria A. Oviatt, Jissy A. Kuriappan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Etoposide is an anticancer drug that acts by inducing topoisomerase II-mediated DNA cleavage. Despite its wide use, etoposide is associated with some very serious side-effects including the development of treatment-related acute myelogenous leukemias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b736d6f326afa297697b207c664276de
https://europepmc.org/articles/PMC6097886/
https://europepmc.org/articles/PMC6097886/