Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alexandre de Lencastre"'
Autor:
Devin Naidoo, Alexandre de Lencastre
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8795 (2024)
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by symptoms such as bradykinesia, resting tremor, and rigidity, primarily driven by the degradation of dopaminergic (DA) neurons in the substantia nigra. A significant co
Externí odkaz:
https://doaj.org/article/151446d6f76d4bdaa85869b754293094
Publikováno v:
Non-Coding RNA, Vol 9, Iss 4, p 41 (2023)
MicroRNAs (miRNAs) perform a pivotal role in the regulation of gene expression across the animal kingdom. As negative regulators of gene expression, miRNAs have been shown to function in the genetic pathways that control many biological processes and
Externí odkaz:
https://doaj.org/article/2b30d788dfcb4c858de268f9b45eb1d2
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40028 (2012)
MicroRNAs (miRNAs) are endogenous small RNA molecules that regulate gene expression post-transcriptionally. Work in Caenorhabditis elegans has shown that specific miRNAs function in lifespan regulation and in a variety of age-associated pathways, but
Externí odkaz:
https://doaj.org/article/60297cb9af6d479198c8da342da0f66b
Publikováno v:
Exp Gerontol
Parkinson’s disease (PD) is a progressive, age-associated neurodegenerative disorder that affects an estimated 10 million people worldwide. PD is characterized by proteinaceous, cytoplasmic inclusions containing α-synuclein, called Lewy Bodies, wh
Publikováno v:
RNA. 24:159-172
Expression levels of many microRNAs (miRNAs) change during aging, notably declining globally in a number of organisms and tissues across taxa. However, little is known about the mechanisms or the biological relevance for this change. We investigated
Publikováno v:
Biochemistry and Molecular Biology Education. 45:351-359
This graduate-level DNA methods laboratory course is designed to model a discovery-based research project and engages students in both traditional DNA analysis methods and modern recombinant DNA cloning techniques. In the first part of the course, st
Publikováno v:
Biomolecular Concepts, Vol 7, Iss 4, Pp 241-252 (2016)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that accounts for the most cases of dementia. AD affects more than 25 million people globally and is predicted to affect nearly one in 85 people worldwide by 2050. AD is character
Publikováno v:
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology. 45(4)
This graduate-level DNA methods laboratory course is designed to model a discovery-based research project and engages students in both traditional DNA analysis methods and modern recombinant DNA cloning techniques. In the first part of the course, st
Autor:
Alexandre, de Lencastre, Frank, Slack
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1343
The rapid development of deep sequencing technologies over the last few years and concomitant increases in sequencing depth and cost efficiencies have opened the door to a ever-widening range of applications in biology-from whole-genome sequencing, t
Autor:
Katherine Zhou, Zachary Pincus, Alexandre de Lencastre, Siu Sylvia Lee, Frank J. Slack, Masaomi Kato
Publikováno v:
Current Biology. 20:2159-2168
Summary Background Aging is under genetic control in C. elegans , but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implic