Výsledky vyhledávání - "Alexandre Vanoosthuyse"

Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

Autor: François Huaux, Ilse Dewachter, Dick Terwel, Sofie Kessels, Chritica Lodder, Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Alexandre Vanoosthuyse, Julien Couturier, Jean-Noël Octave, Bert Brône

Publikováno v: Acta neuropathologica, Vol. 137, no. 4, p. 599-617 (2019)
Acta Neuropathologica

Brains of Alzheimer’s disease patients are characterized by the presence of amyloid plaques and neurofbrillary tangles, both invariably associated with neuroinfammation. A crucial role for NLRP3–ASC infammasome [NACHT, LRR and PYD domains-contain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826f360a579ddf1c4a08a444a4d2309d
https://hdl.handle.net/2078.1/214418

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[P4–037]: IDENTIFICATION OF NOVEL TARGETS FOR INHIBITING PRION‐LIKE SEEDING AND PROPAGATION OF TAU PATHOLOGY IN VITRO AND IN VIVO

Autor: Pascal Kienlen-Campard, Arjan Buist, Peng Wang, Bruno Barbosa de Vasconcelos, Ilse Dewachter, Jean-Noël Octave, Diederik Moechars, Alexandre Vanoosthuyse, Ilie-Cosmin Stancu

Publikováno v: Alzheimer's & Dementia. 13

Background: Positive allosteric modulators of AMPA receptors (AMPA-PAMs) are small molecules that keep the AMPA receptor in an active state by decreasing deactivation or desensitization. They have been proposed to treat cognitive decline in dementias

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a61da489f76ab28044fddfb14a5dcc6
https://doi.org/10.1016/j.jalz.2017.06.1901

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Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

Autor: Ilse Dewachter, Jean-Noël Octave, Bruno Barbosa de Vasconcelos, Pascal Kienlen-Campard, Marcus Bantscheff, Nathalie Pierrot, Alexandre Vanoosthuyse, Ilie-Cosmin Stancu, Gerard Drewes, Diederik Moechars, Gerard Joberty, Maria Faelth-Savitski, Arjan Buist, Peng Wang

Publikováno v: Acta Neuropathologica

Dysregulated proteostasis is a key feature of a variety of neurodegenerative disorders. In Alzheimer's disease (AD), progression of symptoms closely correlates with spatiotemporal progression of Tau aggregation, with "early" oligomeric Tau forms rath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ce83a112578fad77432f9727b22b7e
http://hdl.handle.net/1942/23691

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P3‐072: Identification and Validation of TAU‐Modifiers, Identified by Unbiased Genome Wide Approaches, Using AAV‐Based Approaches in TAU Transgenic Mice

Autor: Alexandre Vanoosthuyse, Ilse Dewachter, Peng Wang, Ilie-Cosmin Stancu, Matthew Bird, Bruno Barbosa de Vasconcelos, Diederik Moechars

Publikováno v: Alzheimer's & Dementia. 12

Background: Identification of Tau mutations linked to neurodegen-erative Tauopathies have indicated that Tau-dysfunction is causally linked to neurodegenerative processes. Accumulating evidence furthermore corroborates a crucial executive role for Ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93eeb3ef3b1aabb3ac96e0c5da6b494f
https://doi.org/10.1016/j.jalz.2016.06.1730

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O5‐04‐01: MOLECULAR MECHANISMS OF ABETA‐INDUCED TAU‐PATHOLOGY: ANALYSIS OF CROSS‐SEEDING OF ABETA AND TAU AND ITS ROLE IN PRION‐LIKE PROPAGATION OF TAU‐PATHOLOGY IN VITRO AND IN VIVO

Autor: Pascal Kienlen-Campard, Kristof Van Kolen, Ilie-Cosmin Stancu, Arjan Buist, Peng Wang, Diederik Moechars, Jean-Noël Octave, Bruno Barbosa de Vasconcelos, An Verheyen, Peter Baatsen, Alexandre Vanoosthuyse, Matthew Bird, Ilse Dewachter

Publikováno v: Alzheimer's & Dementia. 12

tissue homogenates with exogenous Ab1-42 under multiple conditions. Samples were analyzed using acid urea gels followed by Western blotting. Results:The PDAPP mice study revealed Ab42 to Ab40 conversion over time reaching equilibrium by 72hr. Acid ur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418e76db5a051e97cae16325022b2b2b
https://doi.org/10.1016/j.jalz.2016.06.722

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Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

Autor: Matthew Bird, Pascal Kienlen-Campard, Kristof Van Kolen, An Verheyen, Diederik Moechars, Ilse Dewachter, Ilie-Cosmin Stancu, Bruno Barbosa de Vasconcelos, Peter Baatsen, Jean-Noël Octave, Alexandre Vanoosthuyse, Arjan Buist, Peng Wang

Publikováno v: Article
Acta Neuropathologica

Genetic, clinical, histopathological and biomarker data strongly support Beta-amyloid (Aβ) induced spreading of Tau-pathology beyond entorhinal cortex (EC), as a crucial process in conversion from preclinical cognitively normal to Alzheimer's Diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf0320ae313e966d576f12757537df5

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