Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Alexandre Sostelly"'
Publikováno v:
Contemporary Clinical Trials Communications, Vol 26, Iss , Pp 100901- (2022)
Background: Escalation With Overdose Control (EWOC) designs are increasingly used to ensure dose-toxicity curve of investigational oncology drugs is efficiently characterized during dose escalation steps. We propose a novel EWOC-based method that int
Externí odkaz:
https://doaj.org/article/a52fc09ad4fd4cc3980f2b87feecd43c
Autor:
Alexandre Sostelly, François Mercier
Publikováno v:
Clinical Medicine Insights: Oncology, Vol 13 (2019)
Introduction: Ovarian cancer is now recognized as a constellation of distinct subtypes of neoplasia involving the ovary and related structures. As a consequence of this heterogeneity, the analysis of covariates influencing the overall survival is cru
Externí odkaz:
https://doaj.org/article/18df91dc882747ec9d8c16435a30d549
Autor:
Jun‐ichi Nishimura, Antoine Soubret, Noriko Arase, Simon Buatois, Masaki Hotta, Jean‐Eric Charoin, Yoshikazu Ito, Sasha Sreckovic, Hiroyuki Takamori, Christoph Bucher, Yasutaka Ueda, Jules Hernández‐Sánchez, Keisuke Gotanda, Gregor Jordan, Kenji Shinomiya, Julia Ramos, Jin Seok Kim, Jens Panse, Régis Peffault de Latour, Alexander Röth, Eiichi Morii, Hubert Schrezenmeier, Yoshitaka Isaka, Simona Sica, Yuzuru Kanakura, Sung‐Soo Yoon, Taroh Kinoshita, Ido Paz‐Priel, Alexandre Sostelly
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:904-915
Drug–target–drug complexes (DTDCs) are phenomena newly observed in patients who switch from the complement component 5 (C5) inhibitor eculizumab to crovalimab, a novel, anti-C5 antibody in development for paroxysmal nocturnal hemoglobinuria (PNH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f352fecae69e660b9f1196b2bb4809cc
https://doi.org/10.1002/cpt.2851
https://doi.org/10.1002/cpt.2851
Autor:
Simon Buatois, Khaled Benkali, Andrea Henrich, Félix Jaminion, Yuchen Zhang, Alexandre Sostelly
Publikováno v:
Blood. 140:2918-2920
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aede7e0ec5c61818b9f472a86afcf52
https://doi.org/10.1182/blood-2022-158244
https://doi.org/10.1182/blood-2022-158244
Autor:
Jun‐ichi Nishimura, Kensuke Usuki, Julia Ramos, Satoshi Ichikawa, Muriel Buri, Anna Kiialainen, Alexandre Sostelly, Régis Peffault de Latour, Ido Paz‐Priel, Alexander Röth
Publikováno v:
British journal of haematologyREFERENCES. 198(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c88e5f2f202c01b1ba17326a8b89df
https://pubmed.ncbi.nlm.nih.gov/35608260
https://pubmed.ncbi.nlm.nih.gov/35608260
Autor:
Sung Soo Yoon, Hubert Schrezenmeier, Jin Seok Kim, Simona Sica, Kensuke Usuki, Juliette Soret, Jens Panse, Alexandre Sostelly, Junichi Nishimura, Flore Sicre de Fontbrune, Marta Biedzka-Sarek, Brittany Gentile, Judith Anzures-Cabrera, Yoshikazu Ito, Régis Peffault de Latour, Barbara Klughammer, Christoph Bucher, Satoshi Ichikawa, Gregor Jordan, Zsolt Nagy, Andreas Dieckmann, Miklos Egyed, Angelika Jahreis, Alexander Röth, James Higginson, Haruhiko Ninomiya, Kenji Shinomiya, Júlia Gaál-Weisinger
Publikováno v:
Blood. 135:912-920
Complement C5 inhibition is the standard of care (SoC) for patients with paroxysmal nocturnal hemoglobinuria (PNH) with significant clinical symptoms. Constant and complete suppression of the terminal complement pathway and the high serum concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4450a5a46a01ce08bf9db42f378ae41
https://doi.org/10.1182/blood.2019003399
https://doi.org/10.1182/blood.2019003399
Autor:
Anita Appius, Jeffrey J. Pu, Antonio M. Risitano, Lilyan Wright, Guangsheng He, Talha Munir, Sasha Sreckovic, Sven Stanzel, Alexandre Sostelly, Alexander Roeth, Austin G. Kulasekararaj, Junichi Nishimura
Background Crovalimab is a novel anti-complement C5 antibody currently being studied as a treatment for paroxysmal nocturnal hemoglobinuria (PNH), a life-threatening disease associated with hemolytic anemia and thrombosis. Treatment with approved C5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915b9503c9c2b0673d8abec5cb7e23da
Autor:
Caterina P. Minniti, Pablo Bartolucci, Julia Ramos, Diane-Charlotte Imbs, Lucia De Franceschi, Nadiesh Balachandran, Thomas Perretti, Alexandre Sostelly, Michael U. Callaghan, Kenneth I. Ataga
Publikováno v:
Blood. 138:3111-3111
Background SCD is a group of autosomal recessive red blood cell (RBC) disorders caused by a single point mutation in the β- globin gene, with either homozygous inheritance, or heterozygous co-inheritance with other pathogenic variants of the β-glob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::635a4db05b7463cd56846f076cb8603b
https://doi.org/10.1182/blood-2021-151222
https://doi.org/10.1182/blood-2021-151222
Autor:
Caterina P. Minniti, Pablo Bartolucci, Lucia De Franceschi, Kenneth I. Ataga, A. Alexandrou, Himika Patel, Michael U. Callaghan, Jonathan Schimmel, Richard Fox, Alexandre Sostelly, Diane-Charlotte Imbs
Publikováno v:
Blood. 138:3108-3108
Background SCD is a group of autosomal recessive red blood cell (RBC) disorders caused by a single point mutation in the β-globin gene, resulting in the production of hemoglobin S. Hemoglobin S polymerizes within RBCs under certain conditions, leadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f9235a4df2cc9fedbfb198a432276b3
https://doi.org/10.1182/blood-2021-147854
https://doi.org/10.1182/blood-2021-147854
Autor:
Ido Paz-Priel, Julia Ramos, Satoshi Ichikawa, Kensuke Usuki, Jules Hernández-Sánchez, Alexander Röth, Junichi Nishimura, Anna Kiialainen, Régis Peffault de Latour, Alexandre Sostelly
Publikováno v:
Blood. 136:5-6
Background Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the loss of endogenous complement regulators CD59 and CD55 on hematopoietic cells. Peripheral blood elements are susceptible to destruction by complement, resulting in intravasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::691348a473126cd0bf2d09f7a53c4081
https://doi.org/10.1182/blood-2020-136048
https://doi.org/10.1182/blood-2020-136048