Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alexandre Seillier"'
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230238 (2020)
Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, results from deficits in brain endocannabinoid transmission. As cannabis intake has been shown to affect negatively
Externí odkaz:
https://doaj.org/article/44b2bd8d346f4dada0a3f463edd95e4d
Autor:
Alexandre Seillier
Publikováno v:
Web of Science
Owing to its psychotropic effects, Cannabis has been stigmatized by its recreational use leading to a dramatic decline in the experimentations about its medical use in the twentieth century. The medical properties of the plant - known since ancient t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9cde2672f2099a010f9e1d6450511c
https://pubmed.ncbi.nlm.nih.gov/34146641
https://pubmed.ncbi.nlm.nih.gov/34146641
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230238 (2020)
PLoS ONE, Vol 15, Iss 3, p e0230238 (2020)
Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, results from deficits in brain endocannabinoid transmission. As cannabis intake has been shown to affect negatively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3840d0261b4ac3fca8f8916a7fec22
http://europepmc.org/articles/PMC7067407
http://europepmc.org/articles/PMC7067407
Autor:
Lenka Hruba, Alexandre Seillier, Armia Zaki, Andrea Giuffrida, Aron H. Lichtman, Lance R. McMahon, Benjamin F. Cravatt
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 353:261-268
Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) inhibitors exert preclinical effects indicative of therapeutic potential (i.e., analgesia). However, the extent to which MAGL and FAAH inhibitors produce unwanted effects remains un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4c4a647cd56d5aca0741a62079e5ef
https://doi.org/10.1124/jpet.115.222836
https://doi.org/10.1124/jpet.115.222836
Autor:
Alexandre Seillier, Augusta Pisanu, Alex A. Martinez, Maria Grazia Morgese, M. A. Paquette, Anna R. Carta, Andrea Giuffrida, Tommaso Cassano, Teresa Macheda
Publikováno v:
Neurobiology of Disease, Vol 74, Iss, Pp 295-304 (2015)
Long-term administration of l-3,4-dihydroxyphenylalanine (levodopa), the mainstay treatment for Parkinson's disease (PD), is accompanied by fluctuations in its duration of action and motor complications (dyskinesia) that dramatically affect the quali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a8db8e35560a34f14652fb75f3e797
https://doi.org/10.1016/j.nbd.2014.11.024
https://doi.org/10.1016/j.nbd.2014.11.024
Autor:
Alexandre Seillier, Andrea Giuffrida
Publikováno v:
Behavioural pharmacology. 28(7)
Social withdrawal should not be considered a direct measure of the negative symptoms of schizophrenia as it may result not only from asociality (primary negative symptom) but also from other altered processes such as anxiety. To understand the contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59b523dc36863a9c9e14ec543b69c90
https://pubmed.ncbi.nlm.nih.gov/28704273
https://pubmed.ncbi.nlm.nih.gov/28704273
Autor:
Alexandre Seillier, Andrea Giuffrida
Publikováno v:
Neuropharmacology. 130
Experimental evidence suggests that the transport of endocannabinoids might work bi-directionally. Accordingly, it is possible that pharmacological blockade of the latter affects not only the re-uptake, but also the release of endocannabinoids, thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9edb7fb39a2bef13ba77da51e83d27a8
https://pubmed.ncbi.nlm.nih.gov/29169961
https://pubmed.ncbi.nlm.nih.gov/29169961
Publikováno v:
Pharmacology Biochemistry and Behavior. 124:153-159
The biological actions of the endocannabinoids anandamide and 2-arachidonoyl glycerol (2-AG) are terminated by enzymatic hydrolysis of these lipids via fatty acid amide hydrolase (FAAH ) and monoacylglycerol lipase (MAGL), respectively. While several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8ee3d2e1ce07b8bf23c790ec09e5e6
https://doi.org/10.1016/j.pbb.2014.05.022
https://doi.org/10.1016/j.pbb.2014.05.022
Publikováno v:
Neuroscience research. 110
The fatty acid amide hydrolase inhibitor, URB597, an endocannabinoid enhancing drug, reverses social withdrawal in the sub-chronic PCP rat model of schizophrenia, but reduces social interaction (SI) in controls. To identify the anatomical substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf214141e7a0699f9879a1b9429c9ebf
https://pubmed.ncbi.nlm.nih.gov/27091613
https://pubmed.ncbi.nlm.nih.gov/27091613
Publikováno v:
Journal of Experimental Biology. 215:1331-1336
SUMMARY Humans report a wide range of neurobiological rewards following moderate and intense aerobic activity, popularly referred to as the ‘runner’s high’, which may function to encourage habitual aerobic exercise. Endocannabinoids (eCBs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379d142aba4183ec049a4b1f2fb22fc5
https://doi.org/10.1242/jeb.063677
https://doi.org/10.1242/jeb.063677