Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Alexandre S. Boutorine"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1348-1360 (2016)
Efficient protocols based on Cu(I)-catalyzed azide–alkyne cycloaddition were developed for the synthesis of conjugates of pyrrole–imidazole polyamide minor groove binders (MGB) with fluorophores and with triplex-forming oligonucleotides (TFOs). D
Externí odkaz:
https://doaj.org/article/a19f47fd4162467babbf58432d0c792f
Autor:
Alexandre S. Boutorine, Darya S. Novopashina, Olga A. Krasheninina, Karine Nozeret, Alya G. Venyaminova
Publikováno v:
Molecules, Vol 18, Iss 12, Pp 15357-15397 (2013)
This review analyses the literature concerning non-fluorescent and fluorescent probes for nucleic acid imaging in fixed and living cells from the point of view of their suitability for imaging intracellular native RNA and DNA. Attention is mainly pai
Externí odkaz:
https://doaj.org/article/20ea074dc81d4e6bb2eb8332fb2c835b
Autor:
François Loll, Karine Nozeret, Christophe Escudé, Gildas Mouta Cardoso, Alexandre S. Boutorine
Publikováno v:
Biochimie
Biochimie, Elsevier, 2018, ⟨10.1016/j.biochi.2018.03.008⟩
Biochimie, Elsevier, 2018, ⟨10.1016/j.biochi.2018.03.008⟩
International audience; Pericentromeric heterochromatin plays important roles in controlling gene expression and cellular differentiation. Fluorescent pyrrole-imidazole polyamides targeting murine pericentromeric DNA (major satellites) can be used fo
Autor:
D. S. Novopashina, Karine Nozeret, Alya G. Venyaminova, Olga A. Krasheninina, Alexandre S. Boutorine
Publikováno v:
Molecules, Vol 18, Iss 12, Pp 15357-15397 (2013)
Molecules
Molecules
This review analyses the literature concerning non-fluorescent and fluorescent probes for nucleic acid imaging in fixed and living cells from the point of view of their suitability for imaging intracellular native RNA and DNA. Attention is mainly pai
Autor:
Carine Giovannangeli, D. S. Novopashina, Aliya G. Venyaminova, A. N. Sinyakov, Alexandre S. Boutorine, Loïc Perrouault, V. A. Ryabinin
Publikováno v:
Russian Journal of Bioorganic Chemistry. 39:138-152
Triplex forming 3′-protected pyrimidine oligo(2′-O-methylribonucleotides) containing minor groove binders (MGB) and triplex specific intercalator, benzoindoloquinoline (BIQ), at the 5′-terminus were synthesized. The resulting conjugates formed
Publikováno v:
ChemBioChem. 12:2365-2374
The majority of studies on DNA triple helices have been focused on pH-sensitive parallel triplexes with Hoogsteen CT-containing third strands that require protonation of cytosines. Reverse Hoogsteen GT/GA-containing antiparallel triplex-forming oligo
Publikováno v:
Journal of Mass Spectrometry. 44:1171-1181
A new method for the determination of the relative affinity of a ligand against various dsDNA sequences is presented by using electrospray ionization time-of-flight mass spectrometry (ESI-QTOF) mass spectrometry. The principle is described here throu
Autor:
Ludovic Halby, A. N. Surovaya, Sergueï L. Grokhovsky, Vladimir A. Ryabinin, A. N. Sinyakov, G. V. Gursky, Darya S. Novopashina, Alexandre S. Boutorine, Alya G. Venyaminova
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 25:61-76
Two hairpin hexa(N-methylpyrrole)carboxamide DNA minor groove binders (MGB) were linked together via their N-termini in head-to-head orientation. Complex formation between these bis-MGB conjugates and target DNA has been studied using DNase I footpri
Autor:
Serguiy M. Yarmoluk, Alexandre S. Boutorine, Darya S. Novopashina, Karine Nozeret, Marc Bonan
Publikováno v:
Bioorganicmedicinal chemistry. 23(17)
Synthetic minor groove-binding pyrrole–imidazole polyamides labeled by fluorophores are promising candidates for fluorescence imaging of double-stranded DNA in isolated chromosomes or fixed and living cells. We synthesized nine hairpin and two head
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(4)
DNA imaging in living cells usually requires transgenic approaches that modify the genome. Synthetic pyrrole-imidazole polyamides that bind specifically to the minor groove of double-stranded DNA (dsDNA) represent an attractive approach for in-cell i