Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Alexandre Rosa Campos"'
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112436- (2023)
Summary: PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream of PD-1 and requires co-ligation with the T cell receptor (TCR) to atten
Externí odkaz:
https://doaj.org/article/067e0e4ee8fd4b5a973b514304627b4f
Autor:
Zhong Chen, William Hankey, Yue Zhao, Jeff Groth, Furong Huang, Hongyan Wang, Alexandre Rosa Campos, Jiaoti Huang, Robert G. Roeder, Qianben Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
RNA Polymerase II (Pol II) recycling can influence transcription efficiency. Here the authors describe an approach aimed at facilitating the identification of factors involved in Pol II recycling and identify PAF1 complex components as mediators of r
Externí odkaz:
https://doaj.org/article/4eb10231a5c749de806a7d5ca60335db
Autor:
Zhi-Jie Xia, Sonal Mahajan, Earnest James Paul Daniel, Bobby G. Ng, Mayank Saraswat, Alexandre Rosa Campos, Rabi Murad, Miao He, Hudson H. Freeze
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Saul-Wilson syndrome is a rare skeletal dysplasia caused by a heterozygous mutation in COG4 (p.G516R). Our previous study showed that this mutation affected glycosylation of proteoglycans and disturbed chondrocyte elongation and intercalation in zebr
Externí odkaz:
https://doaj.org/article/3b864cc37ccc4109956e83f29288fb72
Autor:
James T. Sorrentino, Gregory J. Golden, Claire Morris, Chelsea D. Painter, Victor Nizet, Alexandre Rosa Campos, Jeffrey W. Smith, Christofer Karlsson, Johan Malmström, Nathan E. Lewis, Jeffrey D. Esko, Alejandro Gómez Toledo
Publikováno v:
mSystems, Vol 7, Iss 4 (2022)
ABSTRACT Vascular dysfunction and organ failure are two distinct, albeit highly interconnected, clinical outcomes linked to morbidity and mortality in human sepsis. The mechanisms driving vascular and parenchymal damage are dynamic and display signif
Externí odkaz:
https://doaj.org/article/7dfffa287d01412680469a2a0ce401c0
Autor:
Alejandro Gómez Toledo, Gregory Golden, Alexandre Rosa Campos, Hector Cuello, James Sorrentino, Nathan Lewis, Nissi Varki, Victor Nizet, Jeffrey W. Smith, Jeffrey D. Esko
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Vascular surfaces are rapidly remodeled during systemic inflammatory responses and sepsis. Here, the authors combine in vivo biotinylation and high-resolution mass spectrometry to characterize organ-level changes of the murine vascular cell surface p
Externí odkaz:
https://doaj.org/article/106260de25614125a608d26e65e99791
Autor:
Marisa Sanchez, Yingying Lin, Chih-Cheng Yang, Philip McQuary, Alexandre Rosa Campos, Pedro Aza Blanc, Dieter A. Wolf
Publikováno v:
iScience, Vol 20, Iss , Pp 466-480 (2019)
Summary: The cellular stress response triggers a cascade of events leading to transcriptional reprogramming and a transient inhibition of global protein synthesis, which is thought to be mediated by phosphorylation of eukaryotic initiation factor-2α
Externí odkaz:
https://doaj.org/article/3c2a06fe56fe42ff9924a05fdd6eb76d
Autor:
Meera Shah, Dan Su, Judith S. Scheliga, Tomáš Pluskal, Susanna Boronat, Khatereh Motamedchaboki, Alexandre Rosa Campos, Feng Qi, Elena Hidalgo, Mitsuhiro Yanagida, Dieter A. Wolf
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1891-1902 (2016)
The multi-subunit eukaryotic translation initiation factor eIF3 is thought to assist in the recruitment of ribosomes to mRNA. The expression of eIF3 subunits is frequently disrupted in human cancers, but the specific roles of individual subunits in m
Externí odkaz:
https://doaj.org/article/1ec21db44c76446c99eebbfd733118c1
Publikováno v:
Oncotarget, vol 13, iss 1
Translocation of Fibroblast Growth Factor Receptors (FGFRs) often leads to aberrant cell proliferation and cancer. The BCR-FGFR1 fusion protein, created by chromosomal translocation t(8;22)(p11;q11), contains Breakpoint Cluster Region (BCR) joined to
Autor:
Hongyan Wang, Robert G. Roeder, Zhong Chen, Yue Zhao, William Hankey, Alexandre Rosa Campos, Jiaoti Huang, Qianben Wang, Jeff Groth, Furong Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
RNA Polymerase II (Pol II) transcriptional recycling is a mechanism for which the required factors and contributions to overall gene expression levels are poorly understood. We describe an in vitro methodology facilitating unbiased identification of
Autor:
Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan Stamm
Publikováno v:
Nucleic acids research. 50(22)
Aggregation of the microtubule-associated protein tau characterizes tauopathies, including Alzheimer's disease and frontotemporal lobar degeneration (FTLD-Tau). Gene expression regulation of tau is complex and incompletely understood. Here we report