Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Alexandre Rohaut"'
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
RAB10 is crucial for the proliferation of the SMAD4-negative SW620 and HT29 cell lines. A, Design of the ND HA-tagged RAB10 allele (HA-RAB10 ND), with seven mutations, including one mutation in the PAM sequence. B, Plasmid used to transfect SW620-pCM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55204daa64254eda277feb69060a8f34
https://doi.org/10.1158/2767-9764.22761834.v1
https://doi.org/10.1158/2767-9764.22761834.v1
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stephane D'Agostino, Sukhvinder S Sidhu, Frederic Lacroix, Vanessa Kolnik, Helene Erasimus
QCsummary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1424a8b7bdc1227bc959dca0697bee
https://doi.org/10.1158/2767-9764.22761804.v1
https://doi.org/10.1158/2767-9764.22761804.v1
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
SMAD4-inducible restoration restores the TGFβ-induced growth inhibition of colorectal cancer cells in vivo.A,In vivo tumorigenicity assay. To assess the effects of SMAD4 restoration in SMAD4-deficient cell lines on tumorigenicity, parental cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da5e3547581eba7c2f8be17bd31a43b
https://doi.org/10.1158/2767-9764.22761849
https://doi.org/10.1158/2767-9764.22761849
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
SMAD4-inducible restoration restores the TGFβ-induced growth inhibition in colorectal and pancreatic cancer cells. A, Protein level of SMAD4 was assessed by Western blot analysis in SMAD4-reexpressing HT29 and SW620 cells. RKO, MDST8 and MIAPaCa-2 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a65bf407becec2e74785e180e6e6e8
https://doi.org/10.1158/2767-9764.22761852.v1
https://doi.org/10.1158/2767-9764.22761852.v1
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
Identification of genes required for SMAD4-deficient cells viability via CRISPR/Cas9 viability screen. A, Identification of top candidates. Top 1,000 hits ranked by MAGeCK for each PD0 versus PD15 comparison were compared trough cell lines, as well t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d83a12bf2bc5ec1467089ffbbf5a65e
https://doi.org/10.1158/2767-9764.22761843
https://doi.org/10.1158/2767-9764.22761843
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
The TGFβ signaling mediator SMAD4 is frequently mutated or deleted in colorectal and pancreatic cancers. SMAD4 acts as a tumor suppressor and its loss is associated with poorer patient outcomes. The purpose of this study was to find synthetic lethal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d622bd65b41d9c4313272e0e3a2506d9
https://doi.org/10.1158/2767-9764.c.6597302
https://doi.org/10.1158/2767-9764.c.6597302
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stephane D'Agostino, Sukhvinder S Sidhu, Frederic Lacroix, Vanessa Kolnik, Helene Erasimus
S2. Quality check of the CRISPR screen samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e86b0bdc1e9eb0283d5ed5bc673a6b
https://doi.org/10.1158/2767-9764.22761828
https://doi.org/10.1158/2767-9764.22761828
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
Association of the expression level of Rab10 with the CNA of SMAD4 in pancreatic and colorectal tumors. Violin plot showing the expression level of Rab10 relative to SMAD4 CNAs in colorectal cancer (TCGA, PanCancer Atlas, 524 patients, *, P < 0.05; A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432ca190c5b490056fb11829147a84ff
https://doi.org/10.1158/2767-9764.22761840.v1
https://doi.org/10.1158/2767-9764.22761840.v1
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stéphane D'Agostino, Sukhvinder Sidhu, Frédéric Lacroix, Vanessa Kolnik, Hélène Erasimus
Validation of the screen showing that disruption of RAB10 decreases proliferation specifically of SMAD4-deficient colorectal and pancreatic cancer cells. A, RAB10 expression assessed with Western blot analysis in the HT29_C4, SW620_C4, DLD1_C5 and MI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0df76866564587c732c91282e7adc3
https://doi.org/10.1158/2767-9764.22761837
https://doi.org/10.1158/2767-9764.22761837
Autor:
Christophe Marcireau, Laurent Debussche, Michel Didier, Gilbert Thill, Isabelle Sanchez, Alexandre Rohaut, Olivier Lemaitre, Stephane D'Agostino, Sukhvinder S Sidhu, Frederic Lacroix, Vanessa Kolnik, Helene Erasimus
Proteins level assessment by western blotting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1c5b942799719e4a155ea622c87e74
https://doi.org/10.1158/2767-9764.22626914
https://doi.org/10.1158/2767-9764.22626914