Zobrazeno 1 - 10
of 464
pro vyhledávání: '"Alexandre R. Zlotta"'
Autor:
Jethro C. C. Kwong, Jeremy Wu, Shamir Malik, Adree Khondker, Naveen Gupta, Nicole Bodnariuc, Krishnateja Narayana, Mikail Malik, Theodorus H. van der Kwast, Alistair E. W. Johnson, Alexandre R. Zlotta, Girish S. Kulkarni
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Accurate prediction of recurrence and progression in non-muscle invasive bladder cancer (NMIBC) is essential to inform management and eligibility for clinical trials. Despite substantial interest in developing artificial intelligence (AI) ap
Externí odkaz:
https://doaj.org/article/30b7b1ffba8f4f0db8849c53dde71700
Publikováno v:
Cancers, Vol 16, Iss 2, p 245 (2024)
Introduction: Intravesical Bacillus Calmette-Guérin (BCG) immunotherapy is the standard of care for high-risk and intermediate-risk non-muscle-invasive bladder cancer (NMIBC) as well as for Carcinoma in situ (CIS). Evidence supports that the differe
Externí odkaz:
https://doaj.org/article/9b3f261e99884a5bbaf4662c2130281b
Autor:
Michael Fraser, Julie Livingstone, Jeffrey L. Wrana, Antonio Finelli, Housheng Hansen He, Theodorus van der Kwast, Alexandre R. Zlotta, Robert G. Bristow, Paul C. Boutros
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Biomarkers of prostate cancer metastasis have been difficult to determine with confidence. Here the authors analyse mutation prevalence in 1844 prostate cancers and show that ZNRF3 loss is enriched in metastatic, castration-resistant prostate cancer
Externí odkaz:
https://doaj.org/article/5be08d8b8b2e4398b9561e54a4056765
Autor:
Esmail M. Al‐Ezzi, Husam A. Alqaisi, Marco A. J. Iafolla, Lisa Wang, Srikala S. Sridhar, Adrian G. Sacher, Nazanin Fallah‐Rad, Di M. Jiang, Geoffrey A. Watson, Charles N. Catton, Padraig R. Warde, Rob J. Hamilton, Neil E. Fleshner, Alexandre R. Zlotta, Aaron R. Hansen
Publikováno v:
Cancer Medicine, Vol 10, Iss 17, Pp 5775-5782 (2021)
Abstract Background In men with metastatic castration‐resistant prostate cancer (mCRPC) with primarily bone metastases, radium‐223 (223Ra) improves overall survival (OS). However, the selection of 223Ra is not guided by specific validated clinico
Externí odkaz:
https://doaj.org/article/da392819a41c4b0387329a1e9a5afd5b
Autor:
Kenneth Wenger, Kayvan Tirdad, Alex Dela Cruz, Andrea Mari, Mayada Basheer, Cynthia Kuk, Bas W.G. van Rhijn, Alexandre R. Zlotta, Theodorus H. van der Kwast, Alireza Sadeghian
Publikováno v:
Machine Learning with Applications, Vol 9, Iss , Pp 100347- (2022)
Recent advances in semi-supervised learning algorithms (SSL) have made great strides in reducing the training dependency on labeled datasets and requiring that only a subset of the data be labeled. The presented work explores a class of semi-supervis
Externí odkaz:
https://doaj.org/article/5cc4f0b5b9084cd097e951809ec524a1
Autor:
Khashayar Habibi, Kayvan Tirdad, Alex Dela Cruz, Kenneth Wenger, Andrea Mari, Mayada Basheer, Cynthia Kuk, Bas W.G. van Rhijn, Alexandre R. Zlotta, Theodorus H. van der Kwast, Alireza Sadeghian
Publikováno v:
Machine Learning with Applications, Vol 9, Iss , Pp 100387- (2022)
Bladder cancer tissue grading, which assigns a numerical grade reflecting how aggressive a tumor looks under a microscope, is essential to determine the proper course of treatment, design a therapeutic plan and determine prognosis. The major problem
Externí odkaz:
https://doaj.org/article/612fbab594ae42f0bcf7ae6a866e79c4
Autor:
Otto Hemminki, Nathan Perlis, Johan Bjorklund, Antonio Finelli, Alexandre R. Zlotta, Akseli Hemminki
Publikováno v:
European Urology Open Science, Vol 22, Iss , Pp 61-73 (2020)
Context: Current guidelines suggest several targeted therapies (TTs) and immunotherapies (ITs) in the treatment of advanced or metastatic renal cell carcinoma (mRCC). Ideal sequencing of these treatments is unclear. Objective: The primary objective w
Externí odkaz:
https://doaj.org/article/22ad140018e9439484414c852cfcdb92
Autor:
Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner, Bharati Bapat
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-19 (2019)
Abstract Background Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifically targeted by androg
Externí odkaz:
https://doaj.org/article/e6d4dc82c3a047528c0b7b4c702f08f0
Autor:
Mandeep K. Gill, Tania Christova, Ying Y. Zhang, Alex Gregorieff, Liang Zhang, Masahiro Narimatsu, Siyuan Song, Shawn Xiong, Amber L. Couzens, Jiefei Tong, Jonathan R. Krieger, Michael F. Moran, Alexandre R. Zlotta, Theodorus H. van der Kwast, Anne-Claude Gingras, Frank Sicheri, Jeffrey L. Wrana, Liliana Attisano
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2 as negative regulator of the Hippo pathway from a siRNA kinome screen and show that NUAK2 promotes YAP/TAZ nuclear localisation while NUAK2 is a transcriptional
Externí odkaz:
https://doaj.org/article/d30df4cc14bf4f8f98f52cdb55527dcc
Autor:
Ekaterina Olkhov-Mitsel, Andrea J. Savio, Ken J. Kron, Vaijayanti V. Pethe, Thomas Hermanns, Neil E. Fleshner, Bas W. van Rhijn, Theodorus H. van der Kwast, Alexandre R. Zlotta, Bharati Bapat
Publikováno v:
Translational Oncology, Vol 10, Iss 2, Pp 168-177 (2017)
Epigenetic changes, including CpG island hypermethylation, occur frequently in bladder cancer (BC) and may be exploited for BC detection and distinction between high-grade (HG) and low-grade (LG) disease. Genome-wide methylation analysis was performe
Externí odkaz:
https://doaj.org/article/557607bc4c4f4d5389c205004827d33c