Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Alexandre Picard"'
Autor:
Anastasiya Strembitska, Gwenaël Labouèbe, Alexandre Picard, Xavier P. Berney, David Tarussio, Maxime Jan, Bernard Thorens
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
During hypoglycemia, glucagon secretion is part of the mechanism needed to restore normal blood glucose levels. Here, Strembitska et al. report that sensing of hypoglycemia by AgRP neurons requires Agpat5, an enzyme which prevents fatty acids from en
Externí odkaz:
https://doaj.org/article/6faf0ec86a64423eb4d8f50809dda608
Autor:
Alexandre Picard, Xavier Berney, Judit Castillo-Armengol, David Tarussio, Maxime Jan, Ana Rodriguez Sanchez-Archidona, Sophie Croizier, Bernard Thorens
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101479- (2022)
Objectives: Glucagon secretion to stimulate hepatic glucose production is the first line of defense against hypoglycemia. This response is triggered by so far incompletely characterized central hypoglycemia-sensing mechanisms, which control autonomou
Externí odkaz:
https://doaj.org/article/2ad4c210c7f44faa88e5c07a91e1f5dc
Publikováno v:
PLoS Biology, Vol 18, Iss 11, p e3000680 (2020)
Proopiomelanocortin (POMC) neurons are major regulators of energy balance and glucose homeostasis. In addition to being regulated by hormones and nutrients, POMC neurons are controlled by glutamatergic input originating from multiple brain regions. H
Externí odkaz:
https://doaj.org/article/08e6a9a39a5d4766ba280c5aad5e9fd8
Autor:
Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens
Publikováno v:
Molecular Metabolism, Vol 35, Iss , Pp - (2020)
Objectives: In the pathogenesis of type 2 diabetes, development of insulin resistance triggers an increase in pancreatic β-cell insulin secretion capacity and β-cell number. Failure of this compensatory mechanism is caused by a dedifferentiation of
Externí odkaz:
https://doaj.org/article/8a631d177faa4ee59bec88c991b20208
Autor:
Alexandre Picard, Josselin Soyer, Xavier Berney, David Tarussio, Simon Quenneville, Maxime Jan, Eric Grouzmann, Frédéric Burdet, Mark Ibberson, Bernard Thorens
Publikováno v:
Cell Reports, Vol 17, Iss 7, Pp 1795-1806 (2016)
The counterregulatory response to hypoglycemia, which restores normal blood glucose levels to ensure sufficient provision of glucose to the brain, is critical for survival. To discover underlying brain regulatory systems, we performed a genetic scree
Externí odkaz:
https://doaj.org/article/fa9e6734855e40f29f329aa32df46e2f
Autor:
Sevasti Gaspari, Gwenaël Labouèbe, Alexandre Picard, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Bernard Thorens
The counterregulatory response to hypoglycemia (CRR), which ensures a sufficient glucose supply to the brain, is an essential survival function. It is orchestrated by incompletely characterized glucose-sensing neurons, which trigger a coordinated aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed3378ac25e885206bfa5bf35e90030d
https://doi.org/10.1101/2022.10.21.513159
https://doi.org/10.1101/2022.10.21.513159
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis
Autor:
Gwenaël Labouèbe, Wanda Dolci, David Tarussio, Salima Metref, Bernard Thorens, Sophie Croizier, Xavier Berney, Alexandre Picard
Publikováno v:
Diabetes
Diabetes, vol. 70, no. 7, pp. 1443-1457
Diabetes, vol. 70, no. 7, pp. 1443-1457
The counterregulatory response to hypoglycemia is an essential survival function. It is controlled by an integrated network of glucose-responsive neurons, which trigger endogenous glucose production to restore normoglycemia. The complexity of this gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac7e8c6f696bbfb9c132d6843dbbbac
https://doi.org/10.2337/db20-1121
https://doi.org/10.2337/db20-1121
Proopiomelanocortin (POMC) neurons are major regulators of energy balance and glucose homeostasis. In addition to being regulated by hormones and nutrients, POMC neurons are controlled by glutamatergic input originating from multiple brain regions. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ead3a2fb5eed960bcb883d085df39be
https://doi.org/10.1101/2020.02.10.941765
https://doi.org/10.1101/2020.02.10.941765
Autor:
Ana Rodriguez Sanchez-Archidona, Davide Basco, David Tarussio, Bernard Thorens, Xavier Berney, Christopher Dumayne, Mark Ibberson, Alexandre Picard
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 35, Iss, Pp-(2020)
Molecular metabolism, vol. 35, pp. 100958
Molecular Metabolism, Vol 35, Iss, Pp-(2020)
Molecular metabolism, vol. 35, pp. 100958
Objectives In the pathogenesis of type 2 diabetes, development of insulin resistance triggers an increase in pancreatic β-cell insulin secretion capacity and β-cell number. Failure of this compensatory mechanism is caused by a dedifferentiation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4d805f67038991e4101f5f1d07c8dc
Publikováno v:
Cahiers de Nutrition et de Diététique. 52:210-217
Resume Le surpoids et l’obesite representent le cinquieme facteur de risque mondial de deces (estimation de 2008, Organisation mondiale de la sante [OMS]). Dans la plupart des cas, l’obesite est due a une deregulation de la balance energetique qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b461cb711029223cb18c823d6acd101
https://doi.org/10.1016/j.cnd.2017.05.001
https://doi.org/10.1016/j.cnd.2017.05.001