Výsledky vyhledávání - "Alexandre Philips"

Resveratrol protects against protease inhibitor-induced reactive oxygen species production, reticulum stress and lipid raft perturbation

Autor: Olivia Touzet, Alexandre Philips

Publikováno v: AIDS. Official journal of the international AIDS Society
AIDS. Official journal of the international AIDS Society, 2010, 24 (10), pp.1437-47. ⟨10.1097/QAD.0b013e32833a6114⟩

International audience; OBJECTIVE: HIV protease inhibitors have been successfully used in highly active antiretroviral therapy of HIV-1 infection, but their benefits are compromised by a number of clinically important adverse side-effects. Several st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd10232666e15258e2aa585d705876f
https://doi.org/10.1097/qad.0b013e32833a6114

Zobrazit plný text záznamu

CHF: a novel factor binding to cyclin A CHR corepressor element

Autor: Annick Vié, Alexandre Philips, Ned J.C. Lamb, Séverine Chambeyron, Jean Marie Blanchard

Publikováno v: Oncogene. 18:6222-6232

Cell cycle modulation of cyclin A expression is due to the periodic relief of a transcriptional repression mediated by a bipartite negative DNA regulatory region. The 5' element (Cell Cycle Responsive Element: CCRE; cell Cycle Dependent Element: CDE)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430149493998554cd4b5c2a3559332fb
https://doi.org/10.1038/sj.onc.1203017

Zobrazit plný text záznamu

Heterodimerization between Members of the Nur Subfamily of Orphan Nuclear Receptors as a Novel Mechanism for Gene Activation

Autor: Christine Martens, Jacques Drouin, Alexandre Philips, Mario Maira

Publikováno v: Molecular and Cellular Biology. 19:7549-7557

We have recently shown that the orphan nuclear receptor Nur77 (NGFI-B) is most active in transcription when it is interacting with a cognate DNA sequence as a homodimer. Further, we have shown that the target for Nur77 dimers, the Nur response elemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893c6cb541de662bfbd6299030a743f0
https://doi.org/10.1128/mcb.19.11.7549

Zobrazit plný text záznamu

Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex

Autor: Yan Geng, Claude Sardet, Magali Olivier, Jolanta Polanowska, Eleonor Ng Eaton, Marie Classon, Eric Fabbrizio, Alexandre Philips, Laurent Le Cam

Publikováno v: The EMBO Journal. 18:1878-1890

Transient induction of the cyclin E gene in late G 1 gates progression into S. We show that this event is controlled via a cyclin E repressor module (CERM), a novel bipartite repressor element located near the cyclin E transcription start site. CERM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4dd79a465f372afe9d9a471dc76f2b9
https://doi.org/10.1093/emboj/18.7.1878

Zobrazit plný text záznamu

Anchorage-dependent expression of cyclin A in primary cells requires a negative DNA regulatory element and a functional Rb

Autor: Ariane Plet, Xavier Huet, Annick Vié, Jean Marie Blanchard, Jocelyne Rech, Alexandre Philips

Publikováno v: Oncogene. 18:1819-1825

Many cells, when cultured in suspension, fail to express cyclin A, a regulatory component of cell cycle kinases cdc2 and cdk2 and as a consequence, do not enter S phase. However, many cell type-specific differences are disclosed between not only norm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc23255efa0b7915df5686f84bb1f0bc
https://doi.org/10.1038/sj.onc.1202530

Zobrazit plný text záznamu

FRA-1 Expression Level Modulates Regulation of Activator Protein-1 Activity by Estradiol in Breast Cancer Cells

Autor: Florence Galtier, Jean-Marc Rey, Dany Chalbos, Corinne Rivier-Covas, Catherine Teyssier, Alexandre Philips, Henri Rochefort

Publikováno v: Molecular Endocrinology. 12:973-985

We compared the effect of estradiol on activator protein-1 (AP-1) activity in estrogen receptor positive (ER alpha+) and estrogen receptor negative (ER alpha-) human breast cancer cell lines transiently transfected with the AP-1-responsive reporter p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c9c6de59748bac8b81911aa2da9ac1
https://doi.org/10.1210/mend.12.7.0133

Zobrazit plný text záznamu

Antagonism between Nur77 and Glucocorticoid Receptor for Control of Transcription

Autor: Mario Maira, Sylvie Lesage, Alaka Mullick, Michel Chamberland, Jacques Drouin, Patrice Hugo, Alexandre Philips

Publikováno v: Europe PubMed Central

Two important functions of glucocorticoids (Gc), namely, suppression of immune system function and feedback repression of the hypothalamo-pituitary-adrenal (HPA) axis, are mediated through repression of gene transcription. Previous studies have indic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8ff58b48e42a4f2d705eb2ead8bf33
https://doi.org/10.1128/mcb.17.10.5952

Zobrazit plný text záznamu

Synthetic antiestrogens modulate induction of pS2 and cathepsin-D messenger ribonucleic acid by growth factors and adenosine 3',5'-monophosphate in MCF7 cells

Autor: Florence Galtier, Henri Rochefort, Dany Chalbos, Alexandre Philips

Publikováno v: Endocrinology. 133:571-576

In MCF7 human breast cancer cells, the antiestrogens 4-hydroxy-tamoxifen and ICI 164,384 inhibit the mitogenic activity of epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I). These growth factors also stimulate the expression of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2e6c994cb2a70e69946a803eea0c3c
https://doi.org/10.1210/endo.133.2.8344199

Zobrazit plný text záznamu

Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans

Autor: Mustapha Sebbane, Gerald Chanques, Valérie Scheuermann, Xavier Capdevila, Samir Jaber, Boris Jung, Jean-Philippe Berthet, Alexandre Mebazaa, Jacques Mercier, Basil J. Petrof, Alain Lacampagne, Dominique Mornet, Hassan Bouyabrine, Christophe Rabuel, Alexandre Philips, Patricia Courouble, Stefan Matecki, Christelle Koechlin-Ramonatxo, Thomas Similowski

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2011, 183 (3), pp.364-371. ⟨10.1164/rccm.201004-0670OC000287294300013⟩
American Journal of Respiratory and Critical Care Medicine, 2011, 183 (3), pp.364-371. ⟨10.1164/rccm.201004-0670OC000287294300013⟩
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2011, 183 (3), pp.364-371. ⟨10.1164/rccm.201004-0670OC⟩

International audience; Rationale. Diaphragmatic function is a major determinant of the ability to successfully wean patients from mechanical ventilation (MV). Paradoxically, MV itself results in a rapid loss of diaphragmatic strength in animals. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b12da6a977f06f2543ca9c5ddf3e73b
https://pubmed.ncbi.nlm.nih.gov/20813887

Zobrazit plný text záznamu

N-acetylcysteine protects against bupivacaine-induced myotoxicity caused by oxidative and sarcoplasmic reticulum stress in human skeletal myotubes

Autor: Annick Bourret, Guillaume Py, Fabien Pillard, Karine Nouette-Gaulain, Jacques Mercier, Olivier Galbes, Stefan Matecki, Alexandre Philips, Xavier Capdevila

Publikováno v: Anesthesiology
Anesthesiology, Lippincott, Williams & Wilkins, 2010, 113 (3), pp.560-9. ⟨10.1097/ALN.0b013e3181e4f4ec⟩
Anesthesiology, 2010, 113 (3), pp.560-9. ⟨10.1097/ALN.0b013e3181e4f4ec⟩

Background Local anesthetics offer the benefits of extended analgesia with greater patient satisfaction and faster rehabilitation compared with intravenous morphine. These benefits, however, can be offset by adverse iatrogenic muscle pain. Here, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9246007286324f2c4ee3ee10e6b7fa
https://hal.archives-ouvertes.fr/hal-00532617/document

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání